Primary renal lymphoma: A population‐based analysis using the SEER program (1973‐2015)

Abstract

Objective Primary renal lymphoma (PRL) is defined as a non‐Hodgkin lymphoma (NHL) restricted to kidneys without extensive nodal disease. The literature on epidemiology and outcome in PRL is limited to case reports and small case series. Methods We utilized Surveillance, Epidemiology, and End Result database (1984‐2015) to study the demographic, clinical, and pathological characteristics of PRL. We conducted analysis to assess factors associated with overall survival (OS) and cause‐specific survival (CSS). Results A total of 599 (0.17% of all NHL) patients were eligible for the study. The age‐adjusted incidence was 0.035/100,000 population and is increasing. The median age was 72 years, and most of the patients were Caucasians and were males. Most of the patients had unilateral tumors, and diffuse large B‐cell lymphoma (DLBCL) was the most common histologic type. The median OS was 112 months, while median CSS was not reached. Age ≥ 60 years was the strongest independent risk factor for worse OS and CSS, while non‐DLBCL histology was associated with better OS and CSS. Discussion Primary renal lymphoma is a rare lymphoma with increasing incidence in more recent years. In this study, we describe demographic, clinical, and pathological characteristics of PRL and factors affecting survival among these patients.

Bilateral primary renal diffuse large B-cell lymphoma: a rare presentation of paediatric renal disease mimicking juvenile nephronophthisis

“…[15,16] More recently, using RNA sequencing of single cells Stewart et al have demonstrated that lymphatic cells are identifiable within the fetal kidney from the first trimester. [17] Presentation is usually unilateral, with bilateral disease usually reported at 10-20% [11] (though a recent population based analysis reported bilateral disease in only 2.7% of 559 cases with a median age of 72 at presentation) [18]. The commonest presenting symptoms include flank pain and an abdominal mass alongside classical "B" symptoms of fevers, fatigue, weight loss and night sweats.…”

Primary, Bilateral and Diffuse Renal Non-Hodgkin’s Lymphoma in a Young Woman Suffering from Turner Syndrome

“…PRL accounts for approximately 0.7–1% of all non-Hodgkin’s lymphomas (NHL), and diffuse large B cell lymphoma (DLBCL) represents the most prevalent pathological histotype [ 1 ]. The median age at diagnosis ranges from 60 to 70 years, with the prevalence in men [ 2 , 3 ]. Conversely, secondary renal involvement is more frequent and could occur in 30–60% of all NHL [ 4 ].…”

“…Typical symptoms of PRL include flank pain, hematuria, weight loss, fever and potential signs of acute or chronic renal failure [ 4 , 5 , 6 ]. PRL has a more frequent monolateral involvement, although bilateral kidney localization could be observed in up to 7.9–20% of cases [ 3 , 7 ]. The disease is typically associated with rapid progression and dismal prognosis, showing a median survival rate of nearly 1 year [ 3 ].…”

“…PRL has a more frequent monolateral involvement, although bilateral kidney localization could be observed in up to 7.9–20% of cases [ 3 , 7 ]. The disease is typically associated with rapid progression and dismal prognosis, showing a median survival rate of nearly 1 year [ 3 ]. In a population-based study from the Surveillance, Epidemiology, and End Results (SEER) database, the 1-year and 5-year relative survival (RS) rates were 78% and 64%, respectively.…”

“…In a population-based study from the Surveillance, Epidemiology, and End Results (SEER) database, the 1-year and 5-year relative survival (RS) rates were 78% and 64%, respectively. An amelioration of OS was observed in the period 2000–2013 in comparison to 1980–1999 due to the introduction of immunotherapy in association with chemotherapy [ 3 ].…”