Primary renal angiosarcoma with progressive clinical course despite surgical and adjuvant treatment: A case report

Çelebi, Filiz; Pilancı, Kezban Nur; Sağlam, Sezer; Balci, N. Cem

doi:10.3892/ol.2015.2902

Cited by 8 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tumor cells are characterized by large hyperchromatic nuclei, prominent nucleoli, and clear cytoplasm. Most tumors are positive for endothelial markers, such as CD31, CD34, FLI‐1, and factor VIII, and negative for CD10, S100, Melan‐A, and HMB‐45 . Although CD34 is a sensitive marker of vascular endothelial cells, CD31 is more sensitive and specific than CD34 and factor VIII in the diagnosis of angiosarcoma .…”

Section: Discussionmentioning

confidence: 99%

Primary renal angiosarcoma: A case report and literature review

Xiang

Guo³

et al. 2018

Precision Radiation Oncology

View full text Add to dashboard Cite

Kidney angiosarcomas usually metastasize from the skin, soft tissue, or visceral primary lesions, whereas primary renal angiosarcomas are rare. We report a case of primary renal angiosarcoma with morphological features similar to those of anastomosis hemangioma. Microscopically, there were multiple irregular anastomosing vascular spaces or channel-like labyrinthine structures, and the tumor cells were positive for CD31, CD34, FLI-1, PAX8, and vimentin; focally positive for factor VIII, CD10, and Ki-67 (approximately 5%); and uniformly-negative for CK, S-100, andMelan-A. The diagnosis of angiosarcoma depends on morphological and immunohistochemical examinations. K E Y W O R D Sangiosarcoma, angiosarcoma of the kidney, primary renal angiosarcoma

show abstract

Section: Discussionmentioning

confidence: 99%

Primary renal angiosarcoma: A case report and literature review

Xiang

Guo³

et al. 2018

Precision Radiation Oncology

View full text Add to dashboard Cite

show abstract

“…Imaging features of renal angiosarcoma are variable, nonspecific, and generally indistinguishable from those of RCC. Ultrasound examination shows a large solid hypoechoic renal mass; one case exhibited peripheral "egg-shell" and central calcifications [58,59].…”

Section: Angiosarcomamentioning

confidence: 99%

“…CT imaging demonstrates a hypodense mass with varying levels of contrast enhancement ranging from none, to heterogeneous, to intense peripheral, to diffuse enhancement [53,54,58,59]. Central areas of necrosis or hemorrhage may be detected [55].…”

Section: Angiosarcomamentioning

confidence: 99%

“…One recent study describes a case treated with neoadjuvant chemoradiation with excellent response, demonstrating potential for this therapeutic approach in future cases [56]. While targeted treatment with anti-angiogenic factors has been utilized with some success in non-renal angiosarcomas, two cases of renal angiosarcoma treated with recombinant interleukin-2 and bevacizumab ultimately resulted in death from disease [49,58]. Nevertheless, experience remains limited and the role of adjuvant therapies in the treatment of renal angiosarcoma remains to be further elucidated.…”

Section: Angiosarcomamentioning

confidence: 99%

See 1 more Smart Citation

Vascular Neoplasms and Related Lesions of Kidney

Lin¹,

Ro²

2020

ann urol oncol

View full text Add to dashboard Cite

Vascular tumors arising in the kidney are distinctly uncommon occurrences and have not been well-characterized in the literature; most cases have been documented in single reports or small case series. These tumors often exhibit nonspecific clinical and radiologic features and may mimic malignant epithelial tumors such as renal cell carcinoma (RCC) on imaging studies, necessitating nephrectomy with pathologic examination for definitive diagnosis. In addition, since primary renal vascular tumors are rare and infrequently encountered in surgical pathology specimens, they are often not considered in the differential diagnosis and therefore may be systematically under-diagnosed. In this review, we discuss the clinical and morphologic features of benign, borderline, and malignant vascular neoplasms and related lesions arising in the kidney, with a focus on recent, clinically relevant advances in imaging, histopathologic diagnosis, and treatment.

show abstract

“…One case was treated with recombinant interleukin-2 therapy and the other, with chemotherapy (oxaliplatin and paclitaxel) and bevacizumab. However, despite treatment, both patients died of disease within 13 months [32,33]. Adjuvant therapies have met with limited success, and patients may develop progressive disease and metastasis regardless of treatment [33].…”

Section: Treatmentmentioning

confidence: 99%

Clinical and Pathologic Features of Primary Angiosarcoma of the Kidney

Omiyale

Carton

2018

Curr Urol Rep

View full text Add to dashboard Cite

Approximately 64 cases have been reported in the literature, and most cases occur in the 6th-7th decade with a strong male predominance. The aetiology is unknown. Patients present with flank pain, haematuria, abdominal mass and weight loss. A considerable number of patients develop metastatic disease at diagnosis or shortly afterwards. Grossly, the tumour comprises ill-defined haemorrhagic spongy masses often with necrosis. Microscopically, the tumour is composed of anastomosing capillary-sized vessels which are lined by malignant endothelial cells. The mainstay of treatment is surgery followed by radiation therapy with or without chemotherapy. Renal angiosarcomas are highly aggressive tumours with dismal outcome, and they must be distinguished from morphologically similar lesions of the kidney.

show abstract

Primary renal angiosarcoma with progressive clinical course despite surgical and adjuvant treatment: A case report

Cited by 8 publications

References 10 publications

Primary renal angiosarcoma: A case report and literature review

Primary renal angiosarcoma: A case report and literature review

Vascular Neoplasms and Related Lesions of Kidney

Clinical and Pathologic Features of Primary Angiosarcoma of the Kidney

Contact Info

Product

Resources

About