Primary refractoriness to platelet transfusion caused by Nak^a antibody alone

Abstract

Clinically significant Nak(a) antibody was present as naturally occurring antibody in a platelet glycoprotein IV (CD36)-negative non-transfused male patient.

Improvement of Anti-CD36 Antibody Detection via Monoclonal Antibody Immobilization of Platelet Antigens Assay by Using Selected Monoclonal Antibodies

“…The prevalence of type I varies among different ethnic groups; it is ~3.0% in the African population, 1.0% in the Japanese population, and ~0.5% in the Chinese population [ 4 - 6 ]. Anti-CD36 isoantibodies (known as anti-Nak a ) can cause different immune-mediated bleeding disorders, including platelet transfusion refractoriness (PTR), fetal neonatal alloimmune thrombocytopenia (FNAIT), and posttransfusion purpura (PTP) [ 7 - 9 ]. Transfusion-related acute lung injury (TRALI) associated with anti-CD36 antibodies (Abs) has also been reported [ 10 ].…”