Primary Pure Choriocarcinoma of the Liver

Alonso, Jorge Fernández; Sáez, Carmen; Pérez, Paz; Montaño, Álvaro; Japón, Miguel Á.

doi:10.1016/s0344-0338(11)81224-0

Cited by 17 publications

(7 citation statements)

References 7 publications

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“…Choriocarcinoma is one of the germ cell tumors composed exclusively of syncytioblastic and cytotrophoblastic cells. 1 Primary hepatic choriocarcinoma (PHC) is characterized by liver involvement without a detectable primary lesion in gonads, retroperitoneum, mediastinum, bladder or prostate. 2 It is extremely rare but highly aggressive germ cell tumor subtype that tends to disseminate even in an early stage.…”

Section: Introductionmentioning

confidence: 99%

Multidisciplinary approach for treatment of primary hepatic choriocarcinoma in adult male patient

Ahn

Kim

Park

et al. 2018

Ann Hepatobiliary Pancreat Surg

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Choriocarcinoma is a rare malignant germ cell tumor and it usually occurs in the gonads (ovary or testis) and uterus. Primary hepatic choriocarcinoma (PHC) is a variant of choriocarcinoma featuring sole liver presentation without any evidence of gonodal involvements. Adult male patients with PHC carry dismal prognosis and their median survival period was less than 5 months. We herein present a first Korean case of a 54-year-old male patient with adult PHC, who was treated by surgical resection and chemotherapy through a multidisciplinary approach.

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Section: Introductionmentioning

confidence: 99%

Multidisciplinary approach for treatment of primary hepatic choriocarcinoma in adult male patient

Ahn

Kim

Park

et al. 2018

Ann Hepatobiliary Pancreat Surg

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“…Primary choriocarcinoma of the liver is an aggressive malignancy frequently associated with clinical instability at initial presentation [ 2 ]. The first description of extragonadal, primarily hepatic choriocarcinoma was published in 1992 [ 3 ]. So far 10 cases of primary choriocarcinomas of the liver are published in the literature including a case series of five cases by Shi et al [ 4 ] (Table 1 ).…”

Section: Discussion and Mini-reviewmentioning

confidence: 99%

“…Histologically, tumors consist of solid papillary proliferation of cytotrophoblastical cells, without secretion of hCG, which are coated by syncytiotrophoblastical giant-cells with hCG secretion [ 10 ]. Neoplastic cells were positive for human chorionic gonadotropin and negative for alpha-fetoprotein and carcinoembryonic antigen [ 3 – 5 ]. The absence of a tumorspecific stroma leads to early vascular infiltration and invasion with accompanying early seeding of distant metastasis.…”

Section: Discussion and Mini-reviewmentioning

confidence: 99%

Primary choriocarcinoma of the liver: a rare, but important differential diagnosis of liver lesions

Köhler

Welsch

Sturm

et al. 2018

Journal of Surgical Case Reports

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The case of a 64-year-old man with spontaneous acute abdominal bleeding is presented. Under suspicion of an atypical hepatocellular carcinoma an extended left hemihepatectomy was performed. Histological diagnosis after surgical therapy revealed a primary hepatic choriocarcinoma. During follow-up within 5 months several metastases were detected. Because of the number and localization of the metastases, there was no further curative surgical option and palliative systemic chemotherapy was initiated. Primary choriocarcinoma of the liver is an important differential-diagnosis in hypervascularized lesions of the liver. This tumor-entity is highly aggressive, with rapid tendency for metastatic spreading. This correlates with the poor prognosis of 12 months after tumor-detection.

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“…Third, this tumor often metastasizes to the para‐aortic lymph nodes. HCC rarely spreads through the lymphatic system, but three patients with primary hepatic choriocarcinoma have had lymph node spread . Interestingly, there have been no reported cases of primary hepatic choriocarcinoma spreading to the thoracic lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors have also been associated with early hematogenous and lymphatic metastasis and resistance to anticancer drugs, leading to an extremely poor prognosis. Non‐gestational choriocarcinomas are extremely rare but have been reported in the testis, ovary, lung, liver, and gastrointestinal tract . Primary hepatic choriocarcinoma is particularly rare, with only 10 reported cases, mostly from China and Japan .…”

mentioning

confidence: 99%

Primary hepatic choriocarcinoma in an 83‐year‐old woman

Fukagawa

Fujita

Ohira

et al. 2017

Pathology International

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We present a case of primary hepatic choriocarcinoma in an 83-year-old Japanese woman with gastric wall and lymph node metastases and a splenic vein tumor thrombus. Multiple irregular hepatic tumors with massive necrosis and hemorrhage were observed during autopsy. Syncytiotrophoblast-like and mononucleated cytotrophoblast-like cell morphology with focal hepatocellular carcinoma (HCC)-like trabecular structures was observed. In immunohistochemical analyses, the tumor cells expressed human chorionic gonadotropin (hCG) and cytokeratins (AE1/AE3, CK7, CK19) but were negative for alpha-fetoprotein (AFP), glypican-3, and vimentin. Immunohistochemical findings did not reveal evidence of HCC or angiosarcoma. We concluded the liver tumor was primary hepatic choriocarcinoma.

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Primary Pure Choriocarcinoma of the Liver

Cited by 17 publications

References 7 publications

Multidisciplinary approach for treatment of primary hepatic choriocarcinoma in adult male patient

Multidisciplinary approach for treatment of primary hepatic choriocarcinoma in adult male patient

Primary choriocarcinoma of the liver: a rare, but important differential diagnosis of liver lesions

Primary hepatic choriocarcinoma in an 83‐year‐old woman

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