Primary Pulmonary Synovial Sarcoma: A Very Rare Presentation

Abstract

Synovial sarcoma (SS) is a rare tumor originating from mesenchymal tissue and accounting for approximately 5–10% of all soft tissue sarcomas. A rare case of primary pulmonary SS in an asymptomatic 18-year-old man admitted to our hospital for investigation of a 6 × 6.5 cm, oval-shaped, well-delineated pleural based peripheral mass in the left lower lobe in his thorax CT is presented. Left lower lobectomy was done. Immunohistochemically, tumor cells were positive for cytokeratin, epithelial membrane antigen (EMA), and vimentin so that the histopathological diagnosis was compatible with biphasic spindle cell type SS in the lung.

Primary sarcomas of the lung: report of five cases and review of the literature

“…Our patient was diagnosed as biphasic synovial sarcoma [32,33]. It is a rare tumor and only 0.1% of all resected malignant lung tumors, also 5-10% of all human soft tissue sarcomas [34][35][36]. They usually occurs in extremity, especially around the knee [37][38][39].…”

“…© Current Thoracic Surgery. All rights reserved.Current Thoracic Surgery-Volume 4 Number 1 p:[34][35][36][37][38][39][40][41] …”

The early-stage of primary pulmonary synovial sarcoma: A case report

“…This type of tumor is very aggressive with poor clinical outcomes [2] , [5] . Primary pulmonary synovial sarcoma could occur in both genders equally [4] , [6] . In chest X-ray, synovial sarcoma often manifests as lung parenchyma mass with well-circumscribed rounded or lobulated borders [3] , [4] , [7] .…”

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“…The molecular analysis shows characteristic chromosomal translocation t (x; 18) which confirms diagnosis in up to 90% patients and is also a poor prognostic feature [6]. In the rest of 10% cases diagnosis is established through histopathology along with immunohistochemistry [6]. The disease has predilection for young male patients [5].…”