Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma with a Nodular Opacity: Report of a Case

Yoshino, Naoyuki; Hirata, Tomomi; Takeuchi, Chie; Usuda, Jitsuo; Hosone, Masaru

doi:10.1272/jnms.84.87

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Atypical clinical symptoms (such as chest cough, discomfort, fever, fatigue, etc.) and radiological characteristics of PPL lead to the difficulties in the disease diagnosis and treatment (9)(10)(11). The present knowledge of PPL is still limited and most studies on PPL are case reports, especially lacking of systematic clinical and radiological performances studies.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study on the clinical characteristics and radiological features of primary pulmonary lymphoma

Xie¹,

Zhang²,

Wu³

et al. 2020

Transl Cancer Res TCR

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Background: The retrospective study was mainly performed to determine the clinical symptoms and radiological characteristics of primary pulmonary lymphoma (PPL) to improve the recognition and diagnosis of the disease.Methods: Between June 2007 and June 2019, the clinical data and radiological images of the 16 patients with PPL confirmed by pathology were retrospectively analyzed.Results: Among the 16 patients with PPL (6 males and 10 females, aged 32 to 72 years, with a median age of 55.13 years), 9 patients were mucosa-associated lymphoid tissue lymphoma (MALT) and 7 patients were diffuse large B-cell lymphoma (DLBCL); all of the patients did not suffer from autoimmune disease [such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Sjogren's syndrome (SSS)]; and 11 patients had a long-term smoking history from 10 to 40 years. The common clinical symptoms were as follows: chest discomfort (n=8), cough (n=10), chest pain (n=7), fever (n=6), apnea (n=1), fatigue (n=4) and weight loss (n=3), however, 6 cases did not show clear symptoms at the time of diagnosis. Blood tests revealed anemia (n=6), thrombocytopenia (n=2), lactate dehydrogenase (LDH) level (n=7), C-reactive protein (CRP) (n=9), erythrocyte sedimentation rate (ESR) (n=8) and no tumor-related indexes were detected abnormal.The chest radiological images showed a total of 8 cases with multiple masses, 2 cases with different types of nodes, 4 cases with patchy infiltration or consolidation shadow, with or without an air bronchogram, and 2 cases with a mixed manifestation. All the lesions were only involved in unilateral lung (13 right, 3 left), none of them located on bilateral lung fields. At the time of admission, the patients were misdiagnosed as lung cancer (n=9), pneumonia (n=5), tuberculosis (n=1), and diffuse interstitial lung disease (n=1). Then final pathological diagnosis was confirmed by surgery (n=9), percutaneous lung biopsy (n=5), and bronchoscopic biopsy (n=2).Conclusions: PPL is a rare disease, though clinical symptoms and radiological characteristics are not typical, they serve as significant clues for the diagnosis and differential diagnosis. Accurate diagnosis mainly depends on histopathological examination, however, conducting a retrospectively study could improve and enrich our knowledge to the disease and reduce inappropriate treatments.

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Section: Introductionmentioning

confidence: 99%

A retrospective study on the clinical characteristics and radiological features of primary pulmonary lymphoma

Xie¹,

Zhang²,

Wu³

et al. 2020

Transl Cancer Res TCR

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“…Primary pulmonary MALT lymphoma, an extranodal marginal low-grade B cell non-Hodgkin lymphoma, is a rare disease [2,15]. However, it is the most common primary pulmonary lymphoma, comprising 70–90% of all cases [2,4,5]. It occurs most commonly in males an average of 60 years old [6,16].…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review

Zhang

Yan

et al. 2018

Med Sci Monit Basic Res

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Background Primary pulmonary mucosa-associated lymphoma tissue lymphoma is rare and is often misdiagnosed because of its diverse and nonspecific clinical features. The aim of this study was to raise awareness among clinicians and to share our experience of treating and managing such patients. Material/Methods This retrospective study was conducted between 1 January 2009 and 31 October 2017 at the First Affiliated Hospital of Guangxi Medical University. All cases were confirmed via pathology and immunohistochemistry. In addition, we reviewed all relevant literature. Results Altogether, 21 patients (7 female, 14 male) with a median age of 54 (range, 19–84) years were diagnosed with primary pulmonary mucosa-associated lymphoma. Expiratory dyspnea, repeated cough and expectoration, and weight loss were the most common symptoms. Pulmonary lesions were found via physical examination in 10 patients who had no obvious symptoms. Chest computed tomography showed nodules, pulmonary consolidation, bronchial bronchogram, ground-glass opacity, and mediastinal lymph node enlargement. Some patients were misdiagnosed with tuberculosis and pneumonia, while others were initially diagnosed with cancer. Tumor pathology and immunocytochemistry indicated primary pulmonary mucosa-associated lymphoma tissue lymphoma. Six patients underwent chemotherapy, 5 underwent surgery, 4 underwent surgery and chemotherapy, 3 were only observed, and 3 refused treatment. Conclusions The development of primary pulmonary mucosa-associated lymphoid tissue lymphoma is slow and insidious. Having no specific clinical symptoms and imaging findings, it is easily misdiagnosed. Final diagnosis is made via pathologic evaluation and immunohistochemistry. Surgery and chemotherapy are the primary treatment modalities and yield a good prognosis.

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“…It is an uncommon neoplasm that represents only 0.4% of primary pulmonary malignancies (3,4). The clinical symptoms and radiological features are often nonspecific, which may often misdiagnose as inflammation, tuberculosis, even lung cancer (5)(6)(7)(8). It is significant for us to increase awareness of this rare disease, which will bring benefits to the therapeutic and prognostic implications.…”

Section: Introductionmentioning

confidence: 99%

A progressive ground-glass opacity occupied the lower left lung in a postoperative colon cancer patient, what it will be?—a case report

Xie¹,

Dong²,

Shen³

2020

Transl Cancer Res TCR

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Primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a type of non-Hodgkin lymphoma, and it occurs frequently in the stomach and rarely in the lungs. They are rarely taken into consideration in the differential diagnosis of lung lesions. MALT lymphomas affecting the lung show various styles on chest CT, which range from typical nodules or areas of consolidation to findings that are extremely rare, such as a progressive ground glass opacity (GGO) that never been reported before especially in a postoperative colon cancer patient. The postoperative pathologic diagnosis of the progressive GGO was extranodal marginal zone B-cell lymphoma of MALT. And during 2-year follow-up, the patient was in good condition and there was no sign of recurrence. This case would enrich the manifestations and increase the understanding in MALT, and inappropriate treatment would be avoided.

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Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma with a Nodular Opacity: Report of a Case

Abstract: Herein, we describe our experience in treating a case of primary pulmonary mucosa-associated lymphoid tissue lymphoma detected as a nodular opacity. A 79-year-old man was referred to our hospital.

Cited by 5 publications

References 7 publications

A retrospective study on the clinical characteristics and radiological features of primary pulmonary lymphoma

A retrospective study on the clinical characteristics and radiological features of primary pulmonary lymphoma

Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review

A progressive ground-glass opacity occupied the lower left lung in a postoperative colon cancer patient, what it will be?—a case report

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