Primary pulmonary leiomyosarcoma—case report of a rare aggressive neoplasm

Ilyas, Mohd; Ahmad, Zubair; Suhail, Jan; Mohammad, Ghulam

doi:10.1007/s12055-017-0643-6

Cited by 2 publications

(8 citation statements)

References 5 publications

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“…Men are reported to have 2-fold higher risk to develop PPL than women. 3,4,6 This is in concordance with our case where the patient was a 51 years old male.…”

Section: Casesupporting

confidence: 92%

“…To date, there are only 14 patients aged over 20 years which have been diagnosed with endobronchial primary pulmonary leiomyosarcoma. 3,4,6 Primary pulmonary leiomyosarcoma (PPL) is a very aggressive tumor that has the capability to grow and to cause symptoms promptly. 3 Around 25% of PPS patients show manifestation of lymph node metastasis.…”

Section: Casementioning

confidence: 99%

“…Primary pulmonary leiomyosarcoma is a very aggressive tumor that has the capability to grow and to cause symptoms very quickly. [1][2][3][4][5] We report a case of pulmonary leiomyosarcoma in a 51-year-old male with the chief complaint of cough in the past 2 weeks before admission. This report will discuss how pulmonary leiomyosarcoma is being treated using Carboplatin/Etoposide chemotherapy based on the existing literatures.…”

Section: Introductionmentioning

confidence: 98%

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Primary Pulmonary Leiomyosarcoma : an Extremely Rare, Difficult-to-Manage Case of Lung Cancer

Binharyanto,

Ngakan Putu Parsama Putra,

Ungky Agus Setyawan

et al. 2023

MRJ

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Background: Primary Pulmonary Leiomyosarcoma (PPL) known as <0.5% of total lung cancer. Histopathological examinations are the pillars of PPL diagnosis as clinical manifestations and radiological features are usually not specific. Treatments of PPL include surgical resection, radiotherapy, and chemotherapy. Case Illustration: A 51-year-old male, smoker, with a productive cough for 2 weeks, accompanied by chest pain, weight loss, and loss of appetite. Imaging studies showed a solid mass in the right lung, which was confirmed through bronchoscopy, cytology, histology, and immunohistochemistry evaluations. Bronchoscopy showed an intraluminal mass in the right main bronchus suggesting malignancy. Immunohistochemistry of Desmin and Smooth Muscle Actin, which were positive, confirmed the diagnosis of PPL of the right lung stage T4N1M1a IVA. Discussion: Surgical resection is the gold standard treatment for PPL whose clinical conditions and tumor spread still allowed for safe operation. Surgical resection did not undergo because already in stage IVA. Radiotherapy and chemotherapy can be added for patients who are unable to have surgery. There are no guidelines regarding chemotherapeutic regimens that are recommended for PPL. Cisplatin/carboplatin and etoposide are two chemotherapeutic agents that are commonly used in other variants of lung cancer. Cisplatin is successful in 5-23% of patients and etoposide is successful in 8%. Doxorubicin and ifosfamide are usually used for soft tissue sarcoma too. After administration of 4 cycles of carboplatin/etoposide, a chest CT scan with contrast recist shows the progression of PPL. Conclusion: Carboplatin and etoposide have been long used as therapy for lung cancer. Currently, available literature shows that their effectiveness in PPL is still considered low. Nevertheless, more studies are needed to further explore the possibilities of using carboplatin and etoposide in PPL patients. Keywords: chemotherapy, lung cancer, primary pulmonary leiomyosarcoma

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“…Men are reported to have 2-fold higher risk to develop PPL than women. 3,4,6 This is in concordance with our case where the patient was a 51 years old male.…”

Section: Casesupporting

confidence: 92%

Section: Casementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Primary Pulmonary Leiomyosarcoma : an Extremely Rare, Difficult-to-Manage Case of Lung Cancer

Binharyanto,

Ngakan Putu Parsama Putra,

Ungky Agus Setyawan

et al. 2023

MRJ

View full text Add to dashboard Cite

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“…Primary pulmonary leiomyosarcomas is a subtype of pulmonary sarcoma, accounting for less than 0.5% of all malignant pulmonary neoplasms. It can originate from the smooth muscles of pulmonary parenchyma, interstitium, or pulmonary vasculatures [ 1 , 2 ]. The clinical presentation ranges from an utterly asymptomatic presentation with accidental discovery on radiologic images to a wide range of nonspecific symptoms such as cough, dyspnea, and chest discomfort [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…It can originate from the smooth muscles of pulmonary parenchyma, interstitium, or pulmonary vasculatures [ 1 , 2 ]. The clinical presentation ranges from an utterly asymptomatic presentation with accidental discovery on radiologic images to a wide range of nonspecific symptoms such as cough, dyspnea, and chest discomfort [ 2 ]. Radiologic imaging modalities help in detecting the tumor´s location and exclude extra-thoracic origin.…”

Section: Introductionmentioning

confidence: 99%

Primary pulmonary leiomyosarcoma with coexistent pulmonary aspergillosis: a case report

Badheeb¹,

Gharem²,

Hammadi³

et al. 2022

Pan Afr Med J

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Coexisting primary pulmonary leiomyosarcoma (PPL) with pulmonary Aspergillosis in immunocompetent patients is a rare occurrence. Here, we presented a 54-year-old woman presented with a dry cough for two months. Bronchoscopy revealed pulmonary aspergillosis. The patient was treated with antifungal therapy for one month without improvement. To evaluate further, a chest computed tomography (CT) scan showed a large heterogeneous enhancing mass in the lower lobe of the left lung with left atrium thrombosis. Computed tomography-guided biopsy was performed, and histopathology demonstrated the diagnosis of PPL. The metastasis workup staging showed multiple metastases in vertebrae, scapula, rib, and liver. The patient was treated with chemotherapy followed by tumor bed radiotherapy. Unfortunately, her general condition worsened, and she passed away with overall survival of fourteen months. In conclusion, clinicians should be alert to underlying malignant disease if airway Aspergillus infection is suspicious in patients without strong risk factors for invasive fungal infection.

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Primary pulmonary leiomyosarcoma—case report of a rare aggressive neoplasm

Cited by 2 publications

References 5 publications

Primary Pulmonary Leiomyosarcoma : an Extremely Rare, Difficult-to-Manage Case of Lung Cancer

Primary Pulmonary Leiomyosarcoma : an Extremely Rare, Difficult-to-Manage Case of Lung Cancer

Primary pulmonary leiomyosarcoma with coexistent pulmonary aspergillosis: a case report

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