Primary pulmonary leiomyoma

Wu, Peng; Venkatachalam, Jonathen; Lee, Victor Kwan Min; Tan, Sze Khen

doi:10.1002/rcr2.153

Cited by 5 publications

(4 citation statements)

References 6 publications

(8 reference statements)

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“…For leiomyomas of the bronchial tree, some authors prefer electric or laser neodymium-doped yttrium aluminum garnet (ND-YAG) endoscopic resection (34,43). In cases where there is a large endobronchial base of implantation surgical removal is recommended.…”

Section: Discussionmentioning

confidence: 99%

Primary Leiomyoma of the Visceral Pleura: An Unexpected Occurrence

Savu

Melinte²,

Gibu³

et al. 2021

In Vivo

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Background/Aim: Leiomyoma is a rare benign tumor originating from smooth muscle fibres. In the respiratory tract, these tumors are rare and in the pleura, cases are exceptional, with only a few reported so far. This is the main reason we decided to present this case of primary leiomyoma of the visceral pleura. Case Report: We present a case of a 51-year-old asymptomatic patient who, during a routine medical examination using standard chest radiography, presented with a 3 by 2 cm homogenous mass in the right superior pulmonary area, tangent to the chest wall (same level with the 3 rd rib). Further investigation using computed tomography (CT) in the chest confirmed the presence of a 31/18 mm solid mass in the right upper lobe, in contact with the parietal pleura. Surgery was performed for two reasons: i) removal of the tumoral mass and ii) establishing a histopathological diagnosis. Intraoperatively, a well-defined, homogenous, ivory white non-infiltrating mass was discovered in the right upper lobe on the visceral pleura and in close proximity to the minor fissure. The mass was removed with negative surgical margins and was left with healthy tissue. Histopathological examination and immunohistochemistry came as a surprise, establishing our diagnosis of leiomyoma. Conclusion: Primitive pleural leiomyoma must remain a possibility when considering the differential diagnosis of pleural tumors. The main course of treatment is complete surgical resection. In our case, longterm follow up did not present any local recurrence.Leiomyoma is a tumor originating in smooth muscular fibres and can occur anywhere in the body where this cell type exists. Leiomyomas are part of the mesenchymal tumor category. Most often, these tumors are present in the uterus, esophagus and small intestine (1, 2). The first description of leiomyoma belongs to Wirshaw in 1854 (1) while Steinard reported the first case of pulmonary leiomyoma in 1939 in a patient that also presented with a uterine fibroma (3). In 1958, Kloepfer described the presence of hereditary leiomyomatosis (2). Other hereditary leiomyomatosis have since been described with multiple simultaneous locations (4); however, the presence in the respiratory tract of a leiomyoma is rare, representing 2% of benign tumors found in this region (5,6).Primary pulmonary leiomyoma was first described in 1907 as a standalone pathology (7), with the first case of pulmonary leiomyoma being reported by Forkel, in 1910 (8).

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Section: Discussionmentioning

confidence: 99%

Primary Leiomyoma of the Visceral Pleura: An Unexpected Occurrence

Savu

Melinte²,

Gibu³

et al. 2021

In Vivo

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“…PPL is vey scarce, and it usually occurs in parenchymal, endotracheal, or endobronchial sites [12]. Endobronchial leiomyoma accounts for 33% of primary pulmonary leiomyoma [ 13] and no epithelial invagination.…”

Section: Discussionmentioning

confidence: 99%

Three unusual Pulmonary fibroleiomyomatous hamartomas: cases report and literature review

Song

Wang

Fu³

2021

Preprint

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BackgroundPulmonary fibroleiomyomatous hamartomas (PFLH) is an extremely rare benign leision, characterized by most patients have no respiratory symptoms and pulmonary nodules is found during rutine chest imaging. It’s completely different from fibrochondrolipoma (ie.chondrogenic pulmonary hamartoma, FCL), Herein, we report three unusual cases of PFLH in a 48-year-old male patient, a 63-year-old male patient and a 63-year-old female patient,respectively and discuss their morphological characteristics and differential diagnoses including fibrochondrolipoma (FCL), pulmonary fibroadenoma (PFA), primary pulmonary leiomyoma (PPL), bronchioloalveolar adenoma (BAA), solitary fibrous tumor (SFT) and pulmonary metastatic leiomyoma (PML) in female patients.Case presentationThree cases showed singler and multiple nodules in the pulmonary parenchyma,the boundary of these nodules was clear. it showed swelling growth and lobulated in larger tumors. it consisted of the mesenchymal rich in spindle cells and the glandular epithelium tissue. the spindle cells form smooth muscle tissue and fibrous tissue, the glandular epithelium with invagination showed glandular ducts or fissures, disorder of composition. Immunohistochemical staining showed Desmin, SMA,H-caldesmon-positive in the all spindle cells; H-caldesmon-positive, SMA-weak positive and desmin-negative in the long spindle cells; TTF-1,CK7 were positive in glandular epithelium and P63,CK5/6 were expressed in basal cells; HMB45,S-100,CD34, ER,PR were negative in all cells. Additionally, Ki-67 VPI was low and less than 1%. The immunohistochemical analysis combined with the morphological results supported the diagnosis of solitary PFLH (SPFLH) or multiple PFLH (M PFLH). There was no recurrence in SPFLH and recurrence in MFLH in the group.ConclusionsPFLH is a rare benign leision .It originated from the small bronchus or smooth muscle cells of vascular wall which implanted into the lung parenchyma and overgrowth into nodules or mass, the messenchymal component of PFLH is the most important for accurate pathological diagnosis, PFLH is easy to be confused with PFA and PPL when there are not enough immune marker such as SMA,desmin, H-caldesmon to mark the mesenchymal components. Therefore, Diagnosis of PFLH mainly depends on pathological examination, females patients have to exclude PML.

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“…Leiomyoma accounts for fewer than 1% of all lung neoplasms [7]. Primary leiomyomas can present as parenchymal, endobronchial, or tracheal.…”

Section: Discussionmentioning

confidence: 99%

“…Leiomyomas were first described by Forkel in 1910 [5]. About one third of these lesions are of endobronchial origin [6,7]. Because of the increasing number of routine chest roentgenograms, these lesions are being discovered more frequently.…”

Section: Introductionmentioning

confidence: 99%

Primary Pulmonary Leiomyoma in a Male

2016

Ann Clin Anal Med

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ÖzetAkciğerin primer pulmoner leiomiyomu benin natürlüdür ve en nadir mezodermal kökenli tümörlerdendir. Rutin göğüs röntgeni çekimlerinin artması ile birlikte bu lezyonlarla daha sıklıkla karşılaşılmağa başlanmıştır. Tedavisi parankim koruyucu rezeksiyondur ve prognozu oldukça iyidir. Otuz yaşında, öksürük, balgam çıkarma ve gece terlemesi şikâyetleri ile başvuran bir erkek hastanın görüntüleme tetkiklerinde sol alt lobda kitle saptanması üzerine yapılan rezeksiyon sonucu primer pulmoner leiomiyom tanısı alan olguyu sunduk. Anahtar KelimelerPrimer; Pulmoner; Leiomiyom AbstractPrimary pulmonary leiomyoma of the lung is benign in nature and is one of the rarest tumors of mesodermal origin. Because of the increasing number of routine chest roentgenograms, these lesions are being discovered more frequently.Treatment is by conservative surgical resection and carries a favorable prognosis.We presented a 30-year-old patient with expectoration cough and night sweats who undergone resection due to a mass in left lower lobe and diagnosed primary pulmonary leiomyoma.

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Primary pulmonary leiomyoma

Cited by 5 publications

References 6 publications

Primary Leiomyoma of the Visceral Pleura: An Unexpected Occurrence

Primary Leiomyoma of the Visceral Pleura: An Unexpected Occurrence

Three unusual Pulmonary fibroleiomyomatous hamartomas: cases report and literature review

Primary Pulmonary Leiomyoma in a Male

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