Primary Pulmonary Hypertension In Israel

Appelbaum, Liat; Yigla, Mordechai; Bendayan, Daniel; Reichart, Nira; Fink, Gershon; Priel, Israel E.; Schwartz, Y.; Richman, P; Picard, Éric; Goldman, Silvia; Kramer, Mordechai R.

doi:10.1378/chest.119.6.1801

Cited by 55 publications

(45 citation statements)

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“…The invasive data show that the selected patients were severe cases, with mean pulmonary artery pressure of 59.3 mmHg and cardiac index of 2.7 L/min/m 2 ( Table 1) and followed the overall gender distribution found in literature, of around two women for every man 5,20 .…”

Section: Discussionsupporting

confidence: 56%

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Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Japyassú¹,

Mendes²,

Bandeira³

et al. 2012

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 56%

“…In a prognostic study with more symptomatic patients (class III/IV), these had significantly lower heart rates and higher risk of death when compared to classes I / II (2.1 ± 0.7 vs. HR. 2.8 ± 0.8, p < 0.007), but there was no significant difference regarding the mean pulmonary artery pressure and pulmonary resistance 20 .…”

Section: Discussionmentioning

confidence: 78%

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Japyassú¹,

Mendes²,

Bandeira³

et al. 2012

Arq. Bras. Cardiol.

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“…This is further strengthened by data collected from Israel. An estimated IPAH incidence rate of 1.4 new cases per million population per year was reported in a retrospective study [15]. This study found a relatively higher incidence rate among the immigrants from Europe and North America as compared with the general population.…”

Section: Discussionmentioning

confidence: 96%

Absence of Human Herpesvirus 8 DNA Sequences in Lung Biopsies from Israeli Patients with Pulmonary Arterial Hypertension

et al. 2006

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Background:Pulmonary hypertension is a severe pulmonary vascular disease leading to rapid deterioration and death. Histological and clinical evidence suggests that smooth muscle proliferation is part of the pathogenesis of the disease. Human herpesvirus 8 (HHV-8) is a γ-herpesvirus that is implicated in malignancies and in Kaposi’s sarcoma. Recently, the association of HHV-8 with idiopathic pulmonary arterial hypertension (PAH) has been found. Objective: The aim of this study was to investigate the presence of HHV-8 in the lung tissue of Israeli patients with PAH. Method: The presence of HHV-8 sequences was investigated by polymerase chain reaction examination in 6 biopsies of patients with pulmonary hypertension. Three patients had idiopathic pulmonary hypertension, 2 patients pulmonary venoocclusive disease, and 1 patient pulmonary hypertension associated with mixed connective tissue disease. Result: We did not find any association between HHV-8 and PAH in these Israeli patients, as all the samples were negative for polymerase chain reaction. Conclusion: Our findings, together with the epidemiological data of HHV-8 prevalence and incidence rates of Kaposi’s sarcoma and PAH in Israel, provide further evidence which argues against an association between HHV-8 infection and PAH.

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“…Several large survival studies of primarily adult patients with primary pulmonary hypertension conducted in the 1980s have provided a basis of comparison for subsequent evolving therapeutic modalities. These retrospective and prospective studies have yielded quite uniform results: adult patients with primary pulmonary hypertension who have not undergone lung or heart/lung transplantation have had actuarial survival rates at 1, 3 and 5 yrs of 68-77, 40-56 and 22-38%, respectively [1,[26][27][28]. However, there is significant biological variability in the natural history of the disease in both adults and children, with some patients having a rapidly progressive downhill course resulting in death within several weeks after diagnosis as well as instances of survival for at least several decades.…”

Section: Natural Historymentioning

confidence: 99%

Pulmonary arterial hypertension in children

2003

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For physicians to admit that a group of patients remains for whom no cure is available in modern medicine is intellectually unsatisfying. Pulmonary arterial hypertension is a rare condition. Because the symptoms are nonspecific and the physical finding can be subtle, the disease is often diagnosed in its later stages. The natural history of pulmonary arterial hypertension is usually progressive and fatal.At the 1998 Primary Pulmonary Hypertension World Symposium, clinical scientists from around the world gathered to review and discuss the future of pulmonary arterial hypertension. Bringing together experts from a variety of disciplines provided the opportunity for a better understanding of the pathology, pathobiology, risk factors, genetics, diagnosis and treatment for pulmonary arterial hypertension.Remarkable progress has been made in the field of pulmonary arterial hypertension over the past several decades. The pathology is now better defined and significant advances have occurred in understanding the pathobiological mechanisms. Risk factors have been identified and the genetics have been characterised. Advances in technology allow earlier diagnosis as well as better assessment of disease severity. Therapeutic modalities such as new drugs, e.g. epoprostenol, treprostinil and bosentan, and surgical interventions, e.g. transplantation and blade septostomy, which were unavailable several decades ago, have had a significant impact on prognosis and outcome. Thus, despite the inability to really cure pulmonary arterial hypertension, therapeutic advances over the past two decades have resulted in significant improvements in the outcome for children with various forms of pulmonary arterial hypertension.This review of pulmonary arterial hypertension will highlight the key features of pulmonary hypertension in infants and children and the current understanding of pulmonary arterial hypertension with specific recommendations for current practice and future directions. Eur Respir J 2003; 21: 155-176.

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Primary Pulmonary Hypertension In Israel

Cited by 55 publications

References 20 publications

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Absence of Human Herpesvirus 8 DNA Sequences in Lung Biopsies from Israeli Patients with Pulmonary Arterial Hypertension

Pulmonary arterial hypertension in children

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