Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules

Cazzuffi, Riccardo; Calia, Nunzio; Ravenna, F; Pasquini, C.; Saturni, Sara; Cavallesco, Giorgio; Quarantotto, Francesco; Rinaldi, Rosa; Cogo, Annaluisa; Caramori, Gaetano; Papi, Alberto

doi:10.1155/2011/262674

Cited by 12 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The radiologic differential diagnoses for pulmonary nodules include metastases, primary lung cancer, lymphoid tumors, benign and malignant vascular tumors, infections, sarcoidosis, and others (10). In cases of metastatic lung tumor, the nodules usually show random distribution and size.…”

Section: Discussionmentioning

confidence: 99%

CT-guided Biopsy for the Diagnosis of Pulmonary Epithelioid Hemangioendothelioma Mimicking Metastatic Lung Cancer

et al. 2018

View full text Add to dashboard Cite

A 69-year-old male patient presented with multiple lung nodules revealed by chest-computed tomography (CT) during a preoperative examination for an appendiceal tumor. The nodule diameters ranged from 2-10 mm without either pleural thickening or effusions. A fluorine-18-labeled fluorodeoxyglucose (F-FDG)-positron emission tomography (PET)/CT scan showed a high FDG uptake in the appendiceal tumor, but almost normal standardized uptake values in the bilateral lung nodules. A CT-guided biopsy led to a diagnosis of pulmonary epithelioid hemangioendothelioma, a rare vascular tumor with a radiological presentation similar to that of a metastatic lung tumor. The present case is the first to describe successful treatment using a CT-guided biopsy instead of more conventional methods.

show abstract

Section: Discussionmentioning

confidence: 99%

CT-guided Biopsy for the Diagnosis of Pulmonary Epithelioid Hemangioendothelioma Mimicking Metastatic Lung Cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…PET/CT findings can demonstrate increased FDG-uptakes but usually are not a pivotal tool for the diagnosis, and a negative PET cannot exclude PEH [ 72 , 73 ]. This false negative result is thought to be caused because of the small size of nodules, little FDG activity in the neoplasm, or low cellular density.…”

Section: Discussionmentioning

confidence: 99%

New Insights about Pulmonary Epithelioid Hemangioendothelioma: Review of the Literature and Two Case Reports

Mesquita

Sousa

Trinidad

et al. 2017

Case Reports in Radiology

View full text Add to dashboard Cite

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare neoplasm of vascular origin. There are three different major imaging patterns identified in thoracic manifestation of epithelioid hemangioendothelioma: (1) multiple pulmonary nodules; (2) multiple pulmonary reticulonodular opacities; and (3) diffuse infiltrative pleural thickening. Radiographically, presence of bilateral multiple nodules is the most common pattern of presentation. The diagnosis is made on the basis of histopathological findings and confirmed by positive immunohistochemistry staining. Although the prognostic factors for PEH have not yet been well established, a better prognosis is usually associated with the multinodular pattern. We report two different imagological presentations of this rare disease, based on two institutional experiences, along with a review of the relevant literature.

show abstract

“…In fact, it is more sensitive than CT scan and bone scintigraphy in detecting PEH metastases. The literature documents several studies demonstrating FDG-uptake in PEH lesions [ 21 - 24 ], although there are few reports of PET-negative pulmonary nodules [ 25 - 30 ]. It can be speculated that FDG uptake is related to the grade of malignancy of PEH nodules and the lack of tracer uptake can be an expression of a more benign character, taking into account that PET scan fails to detect nodules smaller than 6 mm in diameter.…”

Section: Discussionmentioning

confidence: 99%

Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma

Calabrese

Gilli

Rosa³

et al. 2016

Open Medicine

View full text Add to dashboard Cite

AbstractIn this report we describe a case of pulmonary epithelioid hemangioendothelioma (PEH) in a young woman. The neoplasm manifested with dry cough, chest pain, finger clubbing, and multiple bilateral pulmonary nodules on chest x-ray and computed tomographic (CT) scan. She underwent thoracoscopy, and the histological features of the lung biopsies were initially interpreted as consistent with a not-well-defined interstitial lung disease. Our patient was clinically and radiologically stable over a period of four years, after which the disease progressed to involve not only the lung but also mediastinal lymph nodes, liver and bone. Fiberoptic bronchoscopy showed subtotal occlusion of the right middle and lower lobe bronchi. The histologic examination of bronchial biopsies revealed a poorly differentiated neoplasm immunohistochemically positive for vimentin and vascular markers CD31, CD34 and Factor VIII. A diagnosis of malignant hemangioendothelioma was made. Positron emission tomography (PET) is more sensitive than CT scan and bone scintigraphy in detecting PEH metastases. Furthermore, 18-fluorodeoxyglucose (FDG) uptake seems to be related to the grade of malignancy of PEH lesions. Therefore, we suggest that FDG-PET should be included in the staging system and follow-up of PEH.

show abstract

Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules

Cited by 12 publications

References 20 publications

CT-guided Biopsy for the Diagnosis of Pulmonary Epithelioid Hemangioendothelioma Mimicking Metastatic Lung Cancer

CT-guided Biopsy for the Diagnosis of Pulmonary Epithelioid Hemangioendothelioma Mimicking Metastatic Lung Cancer

New Insights about Pulmonary Epithelioid Hemangioendothelioma: Review of the Literature and Two Case Reports

Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma

Contact Info

Product

Resources

About