Primary pulmonary diffuse large B‐cell lymphoma

Wróbel, Tomasz; Dzietczenia, Justyna; Prochorec‐Sobieszek, Monika; Mazur, Grzegorz; Piwkowski, Piotr

doi:10.1002/ajh.22116

Cited by 19 publications

(20 citation statements)

References 5 publications

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“…The criteria for the diagnosis of PPDLBCL include the following: pathological and immunohistochemical features of DLBCL, a primary lesion restricted to the lung (parenchyma and/or bronchi) with or without minimal hilar lymph node involvement, and clinical, radiological, and pathological exclusion of the disease at distant sites. 4 , 5 Our case meets these criteria.…”

Section: Discussionsupporting

confidence: 54%

Primary Pulmonary Diffuse Large B-Cell Lymphoma on FDG PET/CT-MRI and DWI

Wang

et al. 2015

Medicine

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Primary pulmonary diffuse large B-cell lymphoma (PPDLBCL) directly arising from lung tissue is extremely rare. It may usually be misdiagnosed as inflammation including pulmonary tuberculosis, even lung cancer, because its clinical symptoms and signs are often nonspecific. The final diagnosis usually depends on lung biopsy. Herein, we report a case of PPDLBCL and review of diagnosis of this disease, particularly in radiology.A 44-year-old man presented with cough, sputum, and intermittent chest pain for 4 weeks. Multiple radiological examinations showed an irregular mass in the right upper lobe with ground-glass opacities around it and air-filled bronchi in the consolidation. Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography-magnetic resonance imaging (MRI) detected positive FDG uptake, and diffusion-weighted imaging indicated abnormal hyperintension in the lesion. Inflammation was suspected, but malignance cannot be excluded.Finally, ultrasound-guided fine-needle aspiration cytology was performed for histological examination and definitive diagnosis yielded lymphomatous cells infiltration in the right upper lobe.This report emphasizes the significance of multimodality radiological examinations. Multimodality imaging contributes to proper diagnosis, staging, and management of lymphomas.

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Section: Discussionsupporting

confidence: 54%

Primary Pulmonary Diffuse Large B-Cell Lymphoma on FDG PET/CT-MRI and DWI

Wang

et al. 2015

Medicine

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“…[ 2 ] PPL has the most common manifestation as mucosa-associated lymphoid tissue type (MALT) lymphoma, which accounts for about 70% to 90% of cases, and the proportion of primary pulmonary diffuse large B-cell lymphoma (PPL-DLBCL) cases is only 10%. [ 3 ] Because PPL-DLBCL does not have specific symptoms and signs, and imaging results are easily confused with other diseases, PPL-DLBCL is difficult to diagnose.…”

Section: Introductionmentioning

confidence: 99%

CT and PET/CT findings of primary pulmonary diffuse large B-cell lymphoma

Bai

Liang

2017

Medicine

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Rationale:Primary pulmonary diffuse large B-cell lymphoma (PPL-DLBCL) is rare and its clinical manifestations lack specificity. In this report, we present one case of PPL-DLBCL with complete clinical and imaging data, including uncontrast-enhanced CT, contrast-enhanced CT, and positron emission tomography (PET)/CT. Previous cases will also be reviewed and summarized.Patient concerns:A 62-year-old woman was hospitalized due to a swelling pain located in the right side of her back that persisted for >1 month. Local CT examination indicated a pulmonary infection and anti-infective therapy was administered; however, her symptoms did not improve. In the hospital, a lung CT scan with enhancement showed hyperintensity of the right upper lobe (RUL), ill-defined margins, inhomogeneous density, with air bronchograms, and mild-to-moderate enhancement. PET/CT showed a slight hyperintensity of mass with high uptake (about 14.7 standardized uptake value [SUV]), and no high uptake was found in other locations.Interventions:A CT-guided percutaneous needle biopsy with Tru-Cut needles was performed.Diagnoses:The final diagnosis was PPL-DLBCL.Outcomes:After 4 rounds of chemotherapy using the rituximab-cyclophosphamide hydroxydaunorubicin oncovin prednisolone (R-CHOP) regimen, the patient's pain was significantly relieved.Lessons:Finally, the PPL-DLBCL manifestation was similar to other types of PPL clinical manifestations and CT manifestations, but the PPL-DLBCL PET/CT showed an apparent, high metabolism. CT-guided percutaneous transthoracic needle biopsy can clearly diagnose the disease.

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“…The diagnostic criteria for primary lung DLBCL include pathological and immunohistochemical features of DLBCL, a primary lesion restricted to the lung (parenchyma and/or bronchi) with or without minimal hilar lymph node involvement, and clinical, radiological and pathological exclusion of disease at distant sites 3. Both of our cases met these criteria.…”

Section: Discussionmentioning

confidence: 81%