Primary Pulmonary Colloid Adenocarcinoma: A Case Report with Literature Review

Abstract

Pulmonary colloid adenocarcinomas are uncommon tumors individualized as a distinct entity in the histological classification of World Health Organisation of lung tumors characterized by extensive pool of extracellular mucin distending and destroying alveolar walls. We herein report a case of a 63 year-old active man smoker who presented with a worsening dyspnea. A chest computed tomography scan showed a highly suspected irregular nodule of 23 mm in the left-upper lobe. The patient underwent a left-upper lobectomy. Gross examination showed a tan-white cystic nodule measuring 2 cm in greatest dimension filled with gelatinous materiel and microscopic examination revealed an invasive adenocarcinoma with pool of extracellular mucin distending alveolar spaces and destructing their walls. Immunohistochemically, the tumors cells showed diffuse staining for CK7, CDX2, MUC2, MUC5 and focal staining for CK20 and TTF-1. These findings were consistent with the diagnosis of primary pulmonary colloid adenocarcinoma.