Primary pulmonary classical Hodgkin lymphoma: A case report

Schild, Michael H.; Wong, William W.; Valdez, Riccardo; Leis, José F.

doi:10.1002/jso.23624

Cited by 13 publications

(12 citation statements)

References 14 publications

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“…Surgery has been mostly performed in the setting of an uncertain diagnosis. In those cases, it has been suggested that adjuvant chemotherapy and/or postoperative radiation therapy is associated with better disease control than surgery alone [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Hodgkin's Lymphoma: A Rare Etiology of a Cavitary Lung Mass

Hage

Hossri

Samra

et al. 2017

Cureus

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Primary pulmonary Hodgkin's lymphoma (PPHL) is an uncommon disease. This entity is different from Hodgkin’s lymphoma with parenchymal or nodal lung involvement. In this report, we highlight the case of a young female presenting with a six-month history of a productive cough and constitutional B symptoms. Imaging showed cavitary lesions in the right-upper and right-middle lobes. The initial comprehensive infectious workup was negative. Histopathology and immunochemistry confirmed the diagnosis of PPHL. PPHL is an uncommon etiology of cavitary lung lesions. Despite its diagnostic difficulties, awareness of such a disease is crucial, given its high rate of response to treatment, especially in the young population.

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Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Hodgkin's Lymphoma: A Rare Etiology of a Cavitary Lung Mass

Hage

Hossri

Samra

et al. 2017

Cureus

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“…PPHL is a rare visceral Hodgkin disease, comprised of 1.5%–2.4% of primary pulmonary lymphomas, which shows a slight female preponderance (F: M = 1.4: 1) and bimodal age distribution (<35 and >60 years) 3,4 . Clinically, most of the PPHL patients present with unspecific respiratory symptoms, such as cough, hemoptysis, chest pain, and dyspnea, whereas others can also manifest as fever, night sweats, weight loss, or be asymptomatic 5 . Intermittent fever and arthralgia as the predominant symptom of PPHL are quite rare.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Clinically, most of the PPHL patients present with unspecific respiratory symptoms, such as cough, hemoptysis, chest pain, and dyspnea, whereas others can also manifest as fever, night sweats, weight loss, or be asymptomatic. 5 Intermittent fever and arthralgia as the predominant symptom of PPHL are quite rare. When suggestive features such as lymphadenopathy and hepatosplenomegaly are absent at the initial time, these patients may be misdiagnosed with rheumatoid arthritis as in our patient.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary Hodgkin's lymphoma mimicking rheumatoid arthritis‐associated organizing pneumonia: A case report

Sun

Zhou

et al. 2021

Thoracic Cancer

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“…2 The commonest variety of this disease is the nodular sclerosis variant that comprises about 70% of PPHL. 3 PPHL affects women more frequently than men. 1 …”

Section: Discussionmentioning

confidence: 99%

“…2 The commonest variety of this disease is the nodular sclerosis variant that comprises about 70% of PPHL. 3 PPHL affects women more frequently than men. 1 Clinical features of the disease are usually nonspecific, presenting mainly as difficulty in breathing, night sweat, long-standing cough with generalized weakness, and weight loss.…”

Section: Discussionmentioning

confidence: 99%

A Diagnostic Surprise: Primary Hodgkin’s Lymphoma of the Lung

Sinha

Patti

Singh

et al. 2017

Journal of Investigative Medicine High Impact Case Reports

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An 81-year-old male presented to the emergency room with a 3-month history of progressive shortness of breath, productive cough with white sputum, and generalized weakness with 10-pound weight loss in 2 months. On presentation, the patient was afebrile, with blood pressure of 93/55 mm Hg and oxy-hemoglobin saturation of 92% on 2 liters of oxygen via nasal cannula. Complete blood count with differential was significant for white count of 12 400/mL. Brain natriuretic peptide level was 454 ng/mL. Postero-anterior chest radiograph showed multiple round opacities in the lung fields. Computed tomography scan of the chest confirmed multiple round densities in both the lung fields along with mild mediastinal lymphadenopathy. Core needle biopsy was performed. Immunohistochemical stains were positive for CD30 and CD15 in a population of large atypical cells amid a background of CD3-positive nonneoplastic cells. These results were in support of the diagnosis of classical Hodgkin’s lymphoma of the lung with histological appearance confirming nodular sclerosis type. The patient was started on chemotherapy but was readmitted in 20 days for acute respiratory distress and suffered cardiac arrest and subsequently died. This case highlights the fact that although primary pulmonary Hodgkin’s lymphoma of the lung is a rare entity, it should be thought of as a differential while evaluating lung masses. In these cases, definite diagnosis can only be made by biopsy and histology. Early commencement of chemotherapy and regular follow-up with oncology is essential.

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Primary pulmonary classical Hodgkin lymphoma: A case report

Cited by 13 publications

References 14 publications

Primary Pulmonary Hodgkin's Lymphoma: A Rare Etiology of a Cavitary Lung Mass

Primary Pulmonary Hodgkin's Lymphoma: A Rare Etiology of a Cavitary Lung Mass

Primary pulmonary Hodgkin's lymphoma mimicking rheumatoid arthritis‐associated organizing pneumonia: A case report

A Diagnostic Surprise: Primary Hodgkin’s Lymphoma of the Lung

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