Primary process in the photochemistry of fenbufen in acetonitrile

Navaratnam, S.; Jones, S.

doi:10.1016/s1010-6030(00)00199-4

Cited by 10 publications

(1 citation statement)

References 17 publications

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“…Energy transfer was studied by laser flash photolysis at 355 nm of primaquine (0.3 mM) in N 2 -saturated acetonitrile in the presence of fenbufen (6 mM). Fenbufen in acetonitrile shows transient absorption centred at 420 nm which is assigned to its triplet state [13]. The lifetime of the fenbufen triplet is 10±0.…”

Section: Studies Of the Excited State Of Primaquine By Laser Flash Phmentioning

confidence: 99%

Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine

Kristensen

Edge

Tønnesen

et al. 2009

Journal of Photochemistry and Photobiology B: Biology

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The formation and reactivity of excited states and free radicals from primaquine was studied in order to evaluate the primary photochemical reaction mechanisms. The excited primaquine triplet was not detected, but is likely to be formed with a short lifetime (< 50 ns) and with a triplet energy < 250 kJ/mol as the drug is an efficient quencher of the fenbufen triplet and the biphenyl triplet, and forms -is eliminated as a degradation pathway in the photochemical reactions. Impurities in the raw material and photochemical degradation products initiate photosensitized degradation of primaquine in deuterium oxide, prevented by addition of the 1 O 2 quencher sodium azide. Photosensitized degradation by formation of 1 O 2 is thus important for the initial photochemical decomposition of primaquine, which also proceeds by free radical reactions. Formation of PQH 2+

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Section: Studies Of the Excited State Of Primaquine By Laser Flash Phmentioning

confidence: 99%