Primary prevention using statins: to be or not to be?

Breimer, Lars H.; Mikhailidis, D.P.

doi:10.1185/03007995.2010.529887

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…In addition, mortality from coronary heart disease has fallen by half, of which half is owed to improved acute intervention (eg thrombolysis and stenting) and half to reduction in risk factors, especially smoking, cholesterol, and hypertension. 74 Although the evidence from clinical trials is far from convincing, it is likely that certain groups need statins as part of primary prevention.…”

Section: Statins and Hscrpmentioning

confidence: 99%

Inflammation as a Marker for the Prediction of Internal Carotid Artery Restenosis Following Eversion Endarterectomy—Evidence From Clinical Studies

2011

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The role of inflammation is well established in the pathogenesis of atherosclerosis and an increased level of circulating inflammatory markers may predict the future risk of atherosclerosis progression and plaque rupture. C-reactive protein (CRP) identification by hypersensitive methods (high-sensitivity CRP [hsCRP]) has become a clinical and laboratory inflammation marker. Carotid endarterectomy (CEA) is a well-established procedure for carotid stenosis treatment which can reduce stroke rate. Internal carotid artery (ICA) restenosis reduction may be prevented by the anti-inflammatory effect of statins. This review considers the recent findings on the presence of hsCRP and C3 complement concentration and inflammatory plaque composition as well as their effects on ICA restenosis rate, following eversion CEA with emphasis on human studies.

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Section: Statins and Hscrpmentioning

confidence: 99%

Inflammation as a Marker for the Prediction of Internal Carotid Artery Restenosis Following Eversion Endarterectomy—Evidence From Clinical Studies

2011

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“…This may be relevant as apolipoprotein B concentrations represent the number of LDL particles 2 and have been considered as a better indicator of cardiovascular risk than LDL-C with the added advantage of being measured in the non-fasting state 12 . Of note, Florentin et al 1 also reported that high sensitivity C-reactive protein, a predictor of vascular risk, was equally decreased by 23% (p50.05 vs baseline) in both groups.…”

Section: I a L D I S T R I B U T I O N U N A U T H O R I Z E D U S mentioning

confidence: 99%