Primary prevention strategy for cardiovascular disease in Lithuania

Laucevičius, Aleksandras; Rinkūnienė, E.; Ryliškytė, Ligita; Kasiulevičius, Vytautas; Jatužis, Dalius; Petrulionienė, Ž.; Badarienė, Jolita; Navickas, Rokas; Jucevičienė, Agnė; Kutkienė, S.; Solovjova, Svetlana; Andrejevaitė, Viktorija; Lisauskienė, Ingrida; Zupkauskienė, Jūratė; Puronaitė, Roma; Gurevičius, Romualdas; Mikolaitytė, Jurgita

doi:10.2478/semcard-2019-0004

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…The same increase in beta blockers' use was detected in other countries, possibly showing an increase in use in a wide range of cardiovascular diseases [25]. At least in Lithuania, the prevalence of CVD tended to increase until 2014 and declined slightly in 2015-2017, with ischemic heart disease and stroke being the main diseases [38].…”

Section: Discussionmentioning

confidence: 67%

Trend of Antihypertensive Medicine Use in the Baltic States between 2008 and 2018: A Retrospective Cross-National Comparison

Trečiokienė

Bratčikovienė

Gulbinovič

et al. 2022

Pharmacoepidemiology

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High blood pressure is a major risk factor contributing to death and disability rates in the Baltic states. The aim of this study was to compare the utilization of antihypertensive medicines in Estonia, Latvia and Lithuania from 2008 to 2018. In this retrospective cross-national comparison, nationally representative wholesale data from the IQVIA National Retail Audit were analyzed. The utilization of inhibitors of the renin–angiotensin system, beta blockers, calcium channel blockers, diuretics and centrally acting antihypertensives by Defined Daily Doses per 1000 inhabitants and day (DDD/TID) was used to calculate utilization. Time series analysis was used to analyze trends. The utilization increased annually by 10.88, 8.04 and 6.42 DDD/TID in Estonia, Latvia and Lithuania, respectively, from 2008. The utilization of antihypertensive drugs in 2018 was 372, 267 and 379.5 DDD/TID, respectively. Inhibitors of the renin–angiotensin system were the most commonly used class in 2008 and 2018. From 2008, the utilization of beta blockers and fixed-dose combinations including renin–angiotensin system inhibitors increased substantially, while that of calcium channel blockers decreased. Country-specific utilization trends were noted; e.g., the utilization of centrally acting antihypertensives was 30.9 DDD/TID in Lithuania compared to 3.01 DDD/TID in Estonia and 16.17 DDD/TID in Latvia. The use of antihypertensive medicines increased over the study period, but the trends for the different drug classes differed between countries.

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Section: Discussionmentioning

confidence: 67%

Trend of Antihypertensive Medicine Use in the Baltic States between 2008 and 2018: A Retrospective Cross-National Comparison

Trečiokienė

Bratčikovienė

Gulbinovič

et al. 2022

Pharmacoepidemiology

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“…The patient's hyponatremia was classified as hypotonic hyponatremia since serum osmolality was 219 mOsm/kg H 2 O. It was considered severe due to sodium levels <120 mmol/L (10). Due to seizures and impaired consciousness that occurred the first symptoms, it was probably acute hyponatremia (<48 h) (12).…”

Section: Discussionmentioning

confidence: 99%

“…Recognition of beer potomania is a difficult challenge for a physician, particularly in those cases when a patient has other risk factors for developing hyponatremia. Arterial hypertension is a widespread disease usually treated with antihypertensive drugs such as diuretics, which are used in 70.2% cases (10). Moreover, recent studies show that alcohol consumption is also common: in a survey conducted in 2018, 26.5% of people reported they had engaged in binge drinking in the past month.…”

Section: Introductionmentioning

confidence: 99%

Challenges in the diagnostics and management of hydrochlorothiazide-induced severe hyponatremia in a habitual beer drinker

Laubner

Gintautaitė

Badaras

2020

AML

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Introduction. Beer potomania is a syndrome of severe hyponatremia caused by excessive beer consumption. The risk of hyponatremia increases in the case of a combination of beer potomania and the use of thiazide diuretics. Case report. A 55-year-old male patient with the anamnesis of a long-lasting alcohol use disorder was presented to the emergency department after seizures accompanied by an impaired mental status. He had been drinking beer regularly for ten years. On physical examination, the patient was tachypneic, tachycardic, disorientated, restless, the Glasgow Coma Scale score of 9, observed tremor, and the smell of alcohol from the mouth. Laboratory results showed plasma sodium 105 mmol/L, blood urea nitrogen 1.8 mmol/L, the alcohol concentration in the blood 0.06 g/l, and calculated serum osmolality 219 mOsm/kg H2O. After a detailed initial evaluation of the patient and labs for hyponatremia, a diagnosis of beer potomania was established. On the third day of hospitalization, the patient’s anamnesis was filled with information about the use of Valsartan/hydrochlorothiazide, together with reduced salt intake in the diet for three months for arterial hypertension treatment. It was decided that the combination of heavy beer drinking with the use of diuretic and reduced consumption of salt provoked hyponatremia. The patient was treated with infusion therapy of sodium chloride; plasma sodium level reached 136 on the third day of treatment. Conclusions. This case represents an unusual syndrome of beer potomania in conjunction with hydrochlorothiazide usage and reduced salt consumption, which can result in severe hyponatremia that may provoke severe neurologic damage.

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“…All individuals recruited for this study were participants of the ongoing Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program [ 9 , 21 ]. Eligible participants were male (40–55 years) and female (50–65 years) having MetS, which was defined according to the National Cholesterol Education Program (NCEP ATP III) criteria [ 1 ].…”

Section: Methodsmentioning

confidence: 99%

Ambulatory and successive home-based heart rate targeted aerobic training improves arterial parameters: a follow-up study in people with metabolic syndrome

Zupkauskiene,

Lauceviciene,

Ryliskyte

et al. 2023

Annals of Medicine

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Background Studies demonstrated that outpatient aerobic exercise programs (aEP) can significantly decrease aortic stiffness in people with metabolic syndrome (MetS). There is some limited data that remotely supervised home-based aEP can also improve arterial stiffness in this population. We aimed to evaluate the changes in the arterial wall parameters after the 2-month ambulatory supervised aEP followed by the 6-month home-based aEP with and without targeting of heart rate (HR) by electrocardiogram (ECG) in people with MetS. Methods In this prospective study (ClinicalTrials.gov identifier: NCT05592704) 132 MetS subjects (mean age 52.44 ± 6.26 years, 54.55% female) were evaluated. At first, all subjects participated in the 2-month ambulatory supervised aEP, which consisted of 40 individual aerobic training sessions on a cycle ergometer 5 times/week for 40 min and received the recommendations for home-based training. Then the study ( n = 66) and the control ( n = 66) groups participated in the 6-month home-based aEP, but only the study group subjects targeted their HR using ECG monitor connected to the smartphone during workouts. Arterial stiffness parameters and carotid artery intima-media thickness (cIMT) were evaluated in all participants at baseline and after 8 months. Results After 8 months, carotid-femoral pulse wave velocity (c-f PWV) significantly reduced in both groups (−12.22% in the study group vs. −7.85% in the control group, all p < .001) without a significant between-group difference ( p = 0.144). A significant improvement of carotid-radial pulse wave velocity (c-r PWV) was observed only in the study group (-11.37%, p < .001, d = −0.671) with significant between-group difference ( p < .001). The reduction of c-r PWV after 8 months of aEP occurred when c-r PWV at baseline was in the 2nd quartile (>7.90 m/s). A significant decrease of 3.32% in cIMT was present only in the study group ( p = .032, d = −0.288). Conclusions The combination of 2-month ambulatory supervised aEP and successive 6-month home-based aEP targeted by HR monitoring using ECG improved arterial properties in MetS subjects more than the same combination without HR targeting, leading to the greater reduction of c-r PWV and cIMT.

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Primary prevention strategy for cardiovascular disease in Lithuania

Cited by 6 publications

References 30 publications

Trend of Antihypertensive Medicine Use in the Baltic States between 2008 and 2018: A Retrospective Cross-National Comparison

Trend of Antihypertensive Medicine Use in the Baltic States between 2008 and 2018: A Retrospective Cross-National Comparison

Challenges in the diagnostics and management of hydrochlorothiazide-induced severe hyponatremia in a habitual beer drinker

Ambulatory and successive home-based heart rate targeted aerobic training improves arterial parameters: a follow-up study in people with metabolic syndrome

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