Primary Prevention of Cow’s Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow’s Milk Formula at Birth

Urashima, Mitsuyoshi; Mezawa, Hidetoshi; Okuyama, Mai; Urashima, Takashi; Hirano, Daishi; Gocho, N.; Tachimoto, Hiroshi

doi:10.1001/jamapediatrics.2019.3544

Cited by 116 publications

(105 citation statements)

References 35 publications

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“…A recent RCT showed that avoiding cow's milk formula supplementation in newborns for the first 3 days of life reduce sensitization to cow's milk and food allergy (40).…”

Section: Single Allergenic Foodsmentioning

confidence: 99%

“…Similarly, a Finnish cohort study (n = 6,200 infants), with a follow-up of 18-34 months, found that exposure to cow's milk (CM) proteins within the first few days of life increased the risk for CM allergy (34). In contrast, a cohort study from Israel reported that the introduction of CM proteins within the first 2 weeks of life was associated to a lower risk of CM allergy development, and introduction between 4 and 6 months of life was associated to a higher risk (40).…”

Section: Single Allergenic Foodsmentioning

confidence: 99%

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The Role of Diet Diversity and Diet Indices on Allergy Outcomes

et al. 2020

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Nutrients in foods are not eaten in isolation and food intake interacts in a complex manner, affecting health and disease outcomes. For this reason, focusing on the whole "pattern" of dietary intake instead of the single nutrients or groups of nutrients when studying diseases outcomes is increasingly appealing and growing. Diet diversity refers to the variety of foods being eaten, and the terms, diversity or variety, are often used interchangeably. When the overall diet is characterized by healthy foods, diet diversity will reflect a diversity/variety of healthy foods eaten over a period of time. The introduction of solid foods in the 1st year of life is considered a measure of increased diet diversity. Consuming a diverse range of foods and food allergens in the first year of life may increase intake of important nutrients and positively affect the gut microbiome structure and function. Intake of omega-3 fatty acids and fibers/prebiotics may be particularly important but more information is required about dose and which individuals are most likely to benefit. Increased diet diversity in the first year of life is also associated with reduced food allergy outcomes. In addition to diet diversity, diet indices are considered measures of overall diet quality and can be used as a simple assessment of dietary intake. The focus of this paper is to review and critically address the current knowledge of the association between diet diversity and diet indices and allergy outcomes. Based on the current evidence, we recommend the introduction of solid foods, including common allergenic solids, during the 1st year of life, according to the infant's neuro-developmental abilities and familial or cultural habits. For infants with severe AD and/or FA, medical assessment may be advisable before introducing common food allergens into the diet. Limited evidence exist about the role of diet indices in pregnancy and allergic disease in the offspring, and the most promising results indicate a reduction in childhood wheeze and/or asthma intake.

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“…A recent RCT showed that avoiding cow's milk formula supplementation in newborns for the first 3 days of life reduce sensitization to cow's milk and food allergy (40).…”

Section: Single Allergenic Foodsmentioning

confidence: 99%

Section: Single Allergenic Foodsmentioning

confidence: 99%

The Role of Diet Diversity and Diet Indices on Allergy Outcomes

et al. 2020

View full text Add to dashboard Cite

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“…IgE-mediated cow's milk allergy [67]. Urashima et al demonstrated that avoiding cow's milk formula for at least first 3 days of life could prevent from sensitization to cow's milk [68]. In addition, restriction of allergenic foods during pregnancy or breast-feeding is not recommended to prevent FA [69].…”

Section: Oniwaza Et Al Reported That Delayed Introduction Of Cow's Mmentioning

confidence: 99%

IgE-mediated food allergy throughout life

Çelebioğlu¹,

Akarsu²,

Şahiner³

2021

Turk J Med Sci

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Food allergy (FA) is an increasing problem throughout the world. In the last two decades, the frequency of FA has increased in both children and adults. The prevalence differs according to the research methodology, age and geographic regions, ranging between 2.0 to 10.0%. The most common form of FA is IgE mediated FA. In this form, patients may present with life-threatening condition as anaphylaxis or milder conditions like urticaria, angioedema, sneezing and nausea alone. The gold standard in the diagnosis of FA is oral provocation tests. Epidermal skin prick tests and specific IgE measurements as well as component resolved diagnostic techniques are helpful in the diagnosis and follow-up of patients. In this review, the epidemiology, diagnosis, follow-up and prognosis of Ig-E mediated FA in children and adults are discussed and some specific forms of FA such as pollen food allergy syndrome, alpha-gal allergy and food dependent exercise induced anaphylaxis are explained.

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“…Five RCT (Table 1) met the inclusion criteria (29)(30)(31)(32)(33)(34)(35). In 1988, Lindfors and Enocksson (29) and Lindfors et al (30) randomly assigned a 216 healthy term infants to CMF feeding (n = 112) or breastfeeding (n = 104) for the first week of life since their earliest meal (at 6 h of age) and studied the incidence of atopic diseases up to 18 months of age.…”

Section: Description Of Rct Studiesmentioning

confidence: 99%

Primary Prevention of Allergic Diseases: The Role of Early Exposure to Cow's Milk Formula

2020

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The burden of atopic disorders is continuously worsening worldwide, especially in childhood. Therefore, risk factors and preventive measures have been called into question. The age when infants introduce complementary foods, varies greatly according to traditional habits, clinical practice recommendations, and breastfeeding duration. It is still debated the impact of early exposure to cow's milk on the increase of allergic diseases, mainly food allergy, and atopic dermatitis. Many factors may play a role in this potential link, such as genetic variation, parental atopy, infant feeding regimens. Recent evidences suggest that the early introduction of complementary foods (up to 6 months of age), including cow's milk, could prevent the development of food allergies. So, several countries included this new approach into feeding guidelines. Our review will focus on the influence of early exposure to cow's milk formula on the development of allergic diseases. Some trials found that cow's milk supplementation in the first days of life could even increase the development of IgE sensitization and food allergies. Other trials did not show any efficacy on prevention of allergic disorders. Further studies are needed to understand the prospective for allergy prevention related to optimal timing of cow's milk formula introduction.

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Primary Prevention of Cow’s Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow’s Milk Formula at Birth

Cited by 116 publications

References 35 publications

The Role of Diet Diversity and Diet Indices on Allergy Outcomes

The Role of Diet Diversity and Diet Indices on Allergy Outcomes

IgE-mediated food allergy throughout life

Primary Prevention of Allergic Diseases: The Role of Early Exposure to Cow's Milk Formula

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