Primary Posterior Mediastinal Seminoma

Ravenel, James G.; Gordon, Leonie; Block, Mark I.; Chaudhary, Uzair B.

doi:10.2214/ajr.183.6.01831835

Cited by 16 publications

(15 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present case, the mass was located in the posterior mediastinum and it encased the descending thoracic aorta. Although other germ cell neoplasms have been described in the posterior mediastinum (4), to the best of our knowledge, a primary posterior mediastinal seminoma has been previously described only twice in the English medical literature (3,5). Except for the presence of cystic change in the present case, these reports describe imaging appearances that are similar to those in our case, with a confluent posterior mediastinal mass encasing the descending thoracic aorta.…”

Section: Discussionsupporting

confidence: 70%

“…Germ cells can be misplaced in the posterior mediastinum because this area is located in the migration tract during embryogenesis, from the anterior mediastinum to the retroperitoneum, yet germ cell tumors arising in the posterior mediastinum are extremely rare (1,3). In the present case, the mass was located in the posterior mediastinum and it encased the descending thoracic aorta.…”

Section: Discussionmentioning

confidence: 61%

See 1 more Smart Citation

A Posterior Mediastinal Seminoma with Extensive Cystic Change

Lee

Jeon

Park

et al. 2010

J Korean Soc Radiol

View full text Add to dashboard Cite

Seminoma is the most common histologic subtype of malignant germ cell tumors, and it most frequently occurs in the anterior mediastinum in the chest (1). The posterior mediastinum is a rare site of origin for seminoma, and prominent cystic change of a posterior mediastinal seminoma has not been previously described. The present report describes the CT, MR and 18 F-FDG PET/CT findings of a case of a primary posterior mediastinal seminoma that was encasing the descending thoracic aorta and the tumor displayed prominent cystic change. Case ReportA 62-year-old man who complained of back pain for the previous 2 months was referred to our hospital with a posterior mediastinal mass. Chest CT revealed a huge posterior mediastinal mass enveloping the descending thoracic aorta and displacing the heart anteriorly, and also an enlarged left peribronchial lymph node. The mass was well defined with an extensive low attenuation area and periaortic soft tissue components (Fig. 1A). Metastatic bone destruction was noted in the T7-T11 vertebrae. The chest CT obtained at an outside clinic 40 days before admission showed that the cystic area of the mass had heterogeneous high density (31-46 HU) on both the pre-and post-contrast-enhanced imaging. T2-weighted MRI of the chest showed the periaortic soft tissue components and the predominantly cystic nature of the mass (Fig. 1B). The mass displayed heterogeneously low intensity on the T1-weighted image. The posterior mediastinum is a rare site of origin for seminoma, and extensive cystic change of a seminoma is rarely observed. We present here the case of a 62-year-old male patient with a primary posterior mediastinal seminoma that was encasing the descending thoracic aorta and the tumor showed prominent cystic change on CT and MRI, and intense FDG uptake on PET/CT.

show abstract

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 61%

A Posterior Mediastinal Seminoma with Extensive Cystic Change

Lee

Jeon

Park

et al. 2010

J Korean Soc Radiol

View full text Add to dashboard Cite

show abstract

“…Posterior mediastinal seminoma is a rare occurrence with only a few cases reported in the literature. 2,3 Our case was atypical because the tumor extended into the lung, and this led to an initial impression of a primary lung neoplasm.…”

Section: Discussionmentioning

confidence: 90%

“…8 As is the case with extragonadal nonseminomatous germ cell tumors, extragonadal seminomas may present as histologically poorly differentiated carcinoma and should be considered in the differential diagnosis of poorly differentiated cancer. 2 The diagnosis of mediastinal germ cell tumors can be established with a high degree of accuracy through fine needle aspiration biopsy with immunohistochemical analysis. 9 After the diagnosis of a germ cell tumor is made, a primary testicular tumor must be excluded, and ultrasonography should be performed in all patients since testicular palpation is insufficient to exclude a primary testicular tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Posterior mediastinum seminomas are extremely rare with only a few cases previously reported. 2,3 Our case is interesting because it was difficult to differentiate the posterior mediastinal mass from a primary lung tumor due to extension of the mass into the upper and lower lobes of the lung. This feature has not been mentioned in the other case reports.…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

A Rare Case of Posterior Mediastinal Seminoma Mimicking Primary Lung Neoplasm

Lim

Sutamtewagul

Panikkath

et al. 2013

SW Resp Crit Care Chron

View full text Add to dashboard Cite

We report an atypical case of posterior mediastinal seminoma. Mediastinal seminomasare a rare form of tumor usually located in the anterior mediastinum. Our casepresented as a diagnostic challenge because of the difficulty of differentiating the primarymediastinal mass from a primary lung neoplasm. Our case highlights the fact thatseminomas may occur in the posterior mediastinum and the importance of consideringa broad differential diagnosis, especially in cases of poorly differentiated carcinoma ofthe mediastinum.

show abstract

Primary nonseminomatous germ cell tumor in the posterior mediastinum

Wada

Yokoyama

Yamamoto

et al. 2014

Respirology Case Reports

View full text Add to dashboard Cite

A 54-year-old man was admitted to our hospital for further examination following a chest radiographic screening test. He was asymptomatic but had an elevated serum concentration of alpha-fetoprotein. Chest computed tomography (CT) and magnetic resonance imaging showed a posterior mediastinal mass in the left thoracic paravertebral region. CT-guided percutaneous needle biopsy was performed, and the histological findings confirmed nonseminomatous germ cell tumor (NSGCT). Gonadal examination and F-18 fluorodeoxyglucose positron emission tomography findings indicated the posterior mediastinum as the origin of the disease. Reports of primary NSGCT in the posterior mediastinum are extremely rare.

show abstract

Primary Posterior Mediastinal Seminoma

Cited by 16 publications

References 9 publications

A Posterior Mediastinal Seminoma with Extensive Cystic Change

A Posterior Mediastinal Seminoma with Extensive Cystic Change

A Rare Case of Posterior Mediastinal Seminoma Mimicking Primary Lung Neoplasm

Primary nonseminomatous germ cell tumor in the posterior mediastinum

Contact Info

Product

Resources

About