Primary Pleuropulmonary Synovial Sarcoma

Mirzoyan, Michael; Muslimani, Alaa; Setrakian, Sebouh; Swedeh, Mohamed; Daw, Hamed

doi:10.3816/clc.2008.n.040

Cited by 40 publications

(42 citation statements)

References 41 publications

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“…This distinctive chromosomal translocation is present in >90% of synovial sarcomas regardless of subtype, and it appears to be specific. However, there are reports of other tumors like fibrosarcoma and malignant fibrous histiocytoma that have shown the same translocation [10,11]. It has been shown that this translocation correlates with TLE1 expression by immunohistochemistry [26].…”

Section: Discussionmentioning

confidence: 94%

TLE1 is expressed in the majority of primary pleuropulmonary synovial sarcomas

et al. 2011

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Pleuropulmonary synovial sarcoma (PPSS) is a rare entity, similar to synovial sarcoma of soft tissue (STSS). There are 120 published cases of PPSS, but no studies have explored the expression of TLE1. In soft tissues, it has been proven a useful marker, but in tumors of other sites, its expression has not been explored. The main objective was to study the expression and diagnostic sensitivity and specificity of TLE1 in a group of PPSS, of which the diagnosis was corroborated by fluorescence in situ hybridization confirming t(X;18) in a tissue microarray. Immunohistochemistry including TLE1, vimentin, CD99, CD56, bcl-2, AE1-AE3, EMA, CD34, CK7, CK19, calponin, and S-100 was performed on all PPSS and on 25 control cases (five carcinomas, ten mesotheliomas, and ten thoracic sarcomas). TLE1 was positive in 11 cases (73.3%); bcl-2 and vimentin in 100%; calponin and CD56 in 26.6%; CD99, CK AE1-AE3, CK19, CK7, and EMA in 80%; and S100 negative in all. The only biphasic PPSS was positive for epithelial markers only in the epithelial component. TLE1 was negative in all control cases. TLE1 is expressed in 73% of PPSS, a value inferior to that reported in STSS, but is highly specific for PPSS. TLE1 may therefore be of value in the differential diagnosis of PPSS, but should be used in a panel of antibodies.

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Section: Discussionmentioning

confidence: 94%

TLE1 is expressed in the majority of primary pleuropulmonary synovial sarcomas

et al. 2011

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“…Poiché la presenza di metastasi polmonari da sarcoma delle parti molli è più comune rispetto al PPSS [11], la diagnosi deve essere supportata anche dalla storia del paziente, dall'esame clinico e dalla ricerca radiologica di neoplasie in altre sedi. A questo scopo è indicata la PET che mostra un importane aumento dello standard uptake value opathy is signifi cantly more frequent in bronchogenic carcinoma when compared with PSSL where, as already noted, enlarged lymph nodes are rare.…”

Section: Discussionunclassified

“…Given that lung metastases from soft-tissue sarcoma are more common than PSSL [11], the diagnosis should also be supported by medical history, clinical examination and radiological search for tumours in other sites in the body. In conclusione, sebbene il PPSS sia un tumore raro, la presenza di una massa polmonare a densità disomogenea, associata spesso a versamento pleurico, ma senza adenopatie, in un paziente asintomatico o paucisintomatico deve indurre a considerare anche questa neoplasia nel range delle diagnosi differenziali, escludendo la presenza di metastasi a partenza dai più frequenti sarcomi sinoviali a carico delle parti molli.…”

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Synovial sarcoma: CT imaging of a rare primary malignant tumour of the thorax

et al. 2011

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“…A male predominance has been reported [8]. However another study showed that there was no male preponderance [9,10]. In our case the patient was a 35 year-old male.…”

Section: Discussionmentioning

confidence: 44%