Primary peritoneal tuberculosis, a forgotten etiology of portal vein thrombosis

Elleuch, Nour; Sabbek, A.; Hammami, A; Ksiaa, M.; Jmaa, A.

doi:10.1016/j.jdmv.2020.01.151

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Venous thrombosis is a known but rare complication of pulmonary and extrapulmonary tuberculosis, occurring in 1.5%–3.4% of patients[ 34 ]. Intraabdominal TB, such as peritoneum, bowel, lymph node, and solid organ involvements, may be associated with PVT (Table 1 )[ 28 , 35 - 41 ]. All the three parts of Virchow’s triad (hypercoagulability, venous stasis, and endothelial dysfunction) may play a role in the pathogenesis of thromboembolic complications in TB.…”

Section: Discussionmentioning

confidence: 99%

Isolated hepatic tuberculosis associated with portal vein thrombosis and hepatitis B virus coinfection: A case report and review of the literature

Zheng¹,

Lin²,

Tang³

et al. 2021

WJCC

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BACKGROUND While tuberculosis (TB) itself is a common disease, isolated TB of the liver is a rare entity. Tubercular involvement of the liver is more commonly a part of a disseminated disease of the hepatic parenchyma. In contrast, isolated hepatic TB spread through the portal vein from the gastrointestinal tract is seldom encountered in clinical practice, with only a few sporadic cases and short series available in the current literature. Vascular complications, such as portal vein thrombosis (PVT), have rarely been reported previously. CASE SUMMARY A 22-year-old man was hospitalized with complaints of a 3-mo history of fever and weight loss of approximately 10 kg. He had a 10-year hepatitis B virus (HBV) infection in his medical history. Contrast-enhanced computed tomography (CECT) confirmed hepatosplenomegaly, with hypodensity of the right lobe of the liver and 2.1 cm thrombosis of the right branch of the portal vein. A liver biopsy showed epithelioid granulomas with a background of caseating necrosis. Ziehl-Nelson staining showed acid-fast bacilli within the granulomas. The patient was diagnosed with isolated hepatic TB with PVT. Anti-TB therapy (ATT), including isoniazid, rifapentine, ethambutol, and pyrazinamide, was administered. Along with ATT, the patient was treated with entecavir as an antiviral medication against HBV and dabigatran as an anticoagulant. He remained asymptomatic, and follow-up sonography of the abdomen at 4 mo showed complete resolution of the PVT. CONCLUSION Upon diagnosis of hepatic TB associated with PVT and HBV coinfection, ATT and anticoagulants should be initiated to prevent subsequent portal hypertension. Antiviral therapy against HBV should also be administered to prevent severe hepatic injury.

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Section: Discussionmentioning

confidence: 99%

Isolated hepatic tuberculosis associated with portal vein thrombosis and hepatitis B virus coinfection: A case report and review of the literature

Zheng¹,

Lin²,

Tang³

et al. 2021

WJCC

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“…As regard research work about vascular liver disorders in Arab world, we have sixty-four original articles, twenty-eight of them are about Budd Chiari syndrome. Two publications were about hepatic artery diseases, one about ischemic hepatitis, one about congestive hepatopathy (199), and the rest about portal vein thrombosis and portal hypertension (200)(201)(202)(203).…”

Section: Vascular Liver Diseasesmentioning

confidence: 99%