Primary peritoneal serous carcinoma: a primer for radiologists

Gan, Jonathan M; Herzog, Jackson; Smith, Daniel A.; Vos, Derek; Kikano, Elias; Tirumani, Sree H.; Ramaiya, Nikhil H.

doi:10.1016/j.clinimag.2021.12.007

Cited by 1 publication

(4 citation statements)

References 67 publications

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“…In contrast, low-grade serous carcinoma exhibits wild-type p53 staining, negative/patchy p16 staining, and low Ki67 labeling. Furthermore, immunohistochemical evaluation is essential to differentiate from other pathologies, particularly gastrointestinal malignancies [3,12].…”

Section: Discussionmentioning

confidence: 99%

“…These nests are also found in the epithelium of the ovary, which may explain the histopathological similarities between PPSC and low-grade serous ovarian carcinoma [ 2 ]. PPSC occurs in women during the fifth and sixth decades of life, with an estimated incidence of 6.78 cases per million and a median overall survival of 21-23.5 months [ 3 ]. To date, only six cases of PPSC in men have been reported in the literature [ 4 - 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients diagnosed with PPSC present with general abdominal symptoms such as pain, bloating, nausea, vomiting, weight loss, and other unspecified issues [ 3 ]. Some risk factors have been described in the literature including increased age, obesity, hormone replacement, BRCA 1 and BRCA 2 mutation, and first-degree family history of ovarian cancer [ 3 ]. Other studies suggest that PPSC is not associated with BRCA mutation in men or women [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The imaging modalities used for diagnosing and evaluating PPSC include CT, MRI, and PET-CT. The main treatment approach for PPSC involves surgery and chemotherapy, which typically includes primary debulking surgery combined with intraperitoneal or intravenous chemotherapy [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Incidentally Diagnosed Low-Grade Primary Peritoneal Serous Carcinoma Within the Umbilical Hernia Sac in a Male: A Report of an Extremely Rare Case and Review of the Literature

Ganam,

Khan,

Riddle

et al. 2024

Cureus

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Primary peritoneal serous carcinoma (PPSC) is a rare tumor that develops in the peritoneum. PPSC originates from embryonic nests of Müllerian cells in the peritoneum, which are also present in the epithelium of the ovary. This similarity explains the histopathological resemblance between PPSC and low-grade serous ovarian carcinoma. While PPSC primarily affects women, it is an extremely rare occurrence in males, and it is believed that the significant difference in diagnosis rates between males and females is due to the inhibition of Müllerian system growth by substances produced by male Sertoli cells. These substances are present at higher levels in males, which may prevent the development of Müllerian system-derived tumors in men. We describe a 65-year-old male patient who presented for elective bariatric surgery and umbilical hernia repair, and an incidental finding of low-grade PPSC was made based on hernia sac pathology. The patient underwent further management, including tumor debulking and hyperthermic intraperitoneal chemotherapy (HIPEC), with positive outcomes. Long-term follow-up and oral letrozole treatment are planned.

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Section: Discussionmentioning

confidence: 99%