Primary peritoneal hepatoid carcinoma – A case report

Abstract

Introduction: Hepatoid carcinoma (HC) is a rare and aggressive tumor, defined as a primary extrahepatic tumor with morphology similar to hepatocellular carcinoma (HCC). The diagnosis is usually difficult only by the clinical basis and histological examination, but the association with immunohistochemistry may facilitate the diagnosis. Methods: We present an unusual case of primary peritoneal hepatoid carcinoma (PPHC). He is 61 years-old patient with multiple mesenteric and peritoneal tumor nodules. He received neoadjuvant treatment with 9 cycles of GEMOX and sorafenib with partial respose and 90% reduction in alpha-fetoprotein level (AFP) followed by optimal cytoreductive surgery (CRS) and intraperitoneal chemotherapy (HIPEC) with cisplatin. During the 5 month follow-up, there was an increasing in AFP and the investigation showed small peritoneal nodules on the CT Scan. He resumed 5 cycles of same regimen with tumor stabilization followed by second CRS and HIPEC with mitomycin C. He has been followed up, with a 14-month and until now, there is no evidence of recurrence disease. Conclusion: CRS and HIPEC showed be feasible and safe in the treatment of PPHC.