Primary pericardial spindle cell sarcoma mimicking left main coronary artery disease

Abstract

Primary spindle cell sarcoma in the heart is a very uncommon disease. Although primary atrial or pulmonary vein spindle cell sarcomas have been sporadically reported, pericardial spindle cell sarcoma is rarely seen in currently available data. The commentary here is on a primary pericardial spindle cell sarcoma that was preliminarily misjudged to be left main coronary artery disease.

Spindle cell sarcoma of the heart and severe coronary artery disease following successfully treated colon cancer

“…Spindle cell sarcoma of the heart is a very rare tumor which could be primary tumor of the heart or could be a primary lung cancer that metastases to the heart [6]. Spindle cell sarcoma may involve different structures of the heart such as left and right atrium, pulmonary veins, and pericardium [7]. There are many diagnostic modalities for cardiac masses that one covers weakness of other such as Trans-Thoracic Echocardiography (TTE), Trans-Esophageal Echocardiography (TEE), CT scan, and CMR, but early diagnosis of cardiac tumor is limited by lack of early symptoms and also, early treatment is limited by histopathology, location, and extension of Tumor [8].…”

“…Joo Hyun Park et al described a case of pericardial spindle cell sarcoma which at first misdiagnosed as a left main coronary artery disease but then thanks to coronary CT angiography, diagnosed as compression effect of tumor and successfully treated by surgical resection and CABGS [7].…”

Spindle-cell sarcoma of the heart: A rare cause for a cardiac mass

“…Cardiac transplantation is sometimes considered for eligible patients with inoperable sarcomas. Park JH et al ( 6 ) have described a 59-year-old female who initially presented with chest pain and had coronary angiography, revealing critical stenosis of the left main coronary artery ostium. Subsequent echocardiography showed pericardial effusion; after that, coronary multidetector computed tomography (MDCT) angiography showed a cardiac mass compressing the left main coronary artery ostium.…”

The Heart of the Matter: A Unique Convergence of Cardiac Neoplasm, Hereditary Nonpolyposis Colorectal Cancer, and Spindle Cell Sarcoma

“…They are distributed between 12 left atrial tumours, 37,42-52 1 left ventricle tumour, 53 1 right ventricle tumour, 16 and 1 pericardial tumour. 54 The mesenchymal origin of cardiac spindle cell sarcomas explains their predilection to affect large cardiopulmonary blood vessels. 16 Spindle cell sarcomas are typically positive for complex karyotypes encompassing the 12q13-14 region (MDM2 gene).…”