Primary percutaneous coronary intervention for acute myocardial infarction in elderly aged 75 years and over: in-hospital mortality and clinical outcome

Tok, Derya; Turak, Osman; Özcan, Fırat; Durak, Akif; Cagli, Kumral; Başar, Nurcan; İşleyen, Ahmet; Kadife, İskender; Kisacik, Halil

doi:10.5543/tkda.2012.53806

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Sakai et al31 found that overt cardiogenic shock on arrival, anterior myocardial infarction, unsuccessful reperfusion, age >85 years, and female sex were independent predictors of 30-day mortality in a Japanese study of primary PCI for STEMI in the elderly aged ≥75 years. Tok et al32 found that independent predictors of major adverse cardiovascular events after primary PCI in octogenarians included Killip class at admission (OR 4.98, 95% CI 1.25–19.8; P =0.02) and TIMI flow rate after primary PCI (OR 3.42, 95% CI 1.19–10.76; P =0.04). In a report from the American College of Cardiology National Cardiovascular Data Registry, the variables associated with increased mortality were increasing age, recent myocardial infarction and its timing relative to the PCI procedure, renal failure, lung disease, peripheral vascular disease, and ejection fraction <60% 33…”

Section: Predictors Of Mortality In the Elderly With Stemimentioning

confidence: 99%

Percutaneous coronary intervention in the elderly with ST-segment elevation myocardial infarction

Gao¹,

Liu²,

Qin³

et al. 2014

CIA

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As a result of increased life expectancy, octogenarians constitute an increasing proportion of patients admitted to hospital for ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention is currently the treatment of choice for octogenarians presenting with STEMI. The recent literature on this topic has yielded controversial results, even though advances in drug-eluting stents and new types of antithrombotic agents are improving the management of STEMI and postoperative care. In this paper, we review the current status of percutaneous coronary intervention in the elderly with STEMI, including the reasons for their high mortality and morbidity, predictors of mortality, and strategies to improve outcomes.

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Section: Predictors Of Mortality In the Elderly With Stemimentioning

confidence: 99%

Percutaneous coronary intervention in the elderly with ST-segment elevation myocardial infarction

Gao¹,

Liu²,

Qin³

et al. 2014

CIA

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“…AMI is a common, acute and severe disease among cardiovascular diseases. Myocardial necrosis and decreased myocardial contractility lead to congestive heart failure and cardiogenic shock, leading to drop in blood pressure, decreased urine output, and microcirculatory perfusion disorders 5,6. Meanwhile, large amounts of catecholamines and vasopressin are released to worsen the myocardial ischemia and aggravate the ischemia and hypoxia of other organs.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of percutaneous coronary intervention on acute myocardial infarction complicated with multiple organ dysfunction syndrome

et al. 2019

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Objective:To evaluate the clinical efficacy of percutaneous coronary intervention (PCI) on patients with acute myocardial infarction (AMI) complicated with multiple organ dysfunction syndrome (MODS).Methods:A total of 216 patients with AMI complicated with MODS enrolled from January 2016 to March 2018 were divided into a PCI group (n=98) and a drug treatment group (n=118). The baseline clinical data, the incidence of each dysfunction organ, the number of dysfunctional organs and the mortality were compared between the two groups.Results:The number of patients with ST-segment elevation AMI in the PCI group was higher than in the drug treatment group, and the rate of patients with non-ST-segment elevation AMI was lower than in the drug treatment group (P<0.05). The use of temporary pacemakers and IABP was similar between the two groups (P>0.05). The recanalization rate in PCI group was much higher than that in the drug treatment group (P<0.05). The two groups had similar incidence of organ dysfunction in the heart, lungs, kidneys, stomach and intestine, etc. and the PCI group had lower organ dysfunction incidence in the liver, brain and hematological system than the drug treatment group (P<0.05). The dysfunction incidence rate of two organs was higher in PCI group than in drug treatment group (P<0.05), the dysfunction incidence rate of 3 organs was similar between the two groups, and the dysfunction incidence rate of three organs or more was significantly lower in PCI group than in drug treatment group (P<0.05).Conclusion:Despite the high risk and high mortality of patients with AMI plus MODS, clinical improvement can still be achieved when effective PCI is performed.

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“…AMI is a common, acute and severe disease among cardiovascular diseases. Myocardial necrosis and decreased myocardial contractility give birth to congestive heart failure and cardiogenic shock, leading to drop in blood pressure, decreased urine output, and microcirculatory perfusion disorders [6]. Meanwhile, large amounts of catecholamines and vasopressin were released to worsen the myocardial ischemia and aggravate the ischemia and hypoxia of other organs.…”

Section: Discussionmentioning

confidence: 99%

Clinical Treatment Efficacy of Percutaneous Coronary Intervention Therapy on Acute Myocardial Infarction Complicated with Multiple Organ Dysfunction Syndrome

Peng¹,

Wang²,

Ma³

2019

AJLS

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Objective: This study aims to evaluate the clinical efficacy of the percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) complicated by multiple organ dysfunction syndrome (MODS). Methods: 216 patients with AMI complicated by MODS hospitalized in the Department of Cardiology of our hospital from January 2011 to March 2013 were divided into a PCI group (n=98) and a drug treatment group (n=118). The basic clinical data, the incidence rate of each dysfunction organ, the number of dysfunction organs and the mortality were compared between the two groups. Results: The rate of patients with ST-segment elevation AMI in the PCI group was higher than in the drug treatment group, and the rate of patients with non-ST-segment elevation AMI was lower than in the drug treatment group (P<0.05). The use of temporary pacemakers and IABP was similar between the two groups (P>0.05). The recanalization rate in PCI group was much higher than that in the drug treatment group (P<0.05). The two groups had similar rates in the incidence of organ dysfunction in the heart, lungs, kidneys, stomach and intestine, etc. and the PCI group had lower organ dysfunction incidence rate in the liver, brain and hematological system than the drug treatment group (P<0.05). The dysfunction incidence rate of 2 organs was higher in PCI group than in drug treatment group (P<0.05), the dysfunction incidence rate of 3 organs was similar between the two groups, and the dysfunction incidence rate of 3 organs or more was significantly lower in PCI group than in drug treatment group (P<0.05). Conclusion: Despite the high risk and high mortality in the patients with AMI complicated by MODS, satisfactory clinical efficacy can still be achieved as long as positive and effective PCI therapy is applied.

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Primary percutaneous coronary intervention for acute myocardial infarction in elderly aged 75 years and over: in-hospital mortality and clinical outcome

Abstract: Our study revealed a high rate of MACE in patients older than 75 years admitted with STEMI regardless of undergoing primary PCI.

Cited by 3 publications

References 24 publications

Percutaneous coronary intervention in the elderly with ST-segment elevation myocardial infarction

Percutaneous coronary intervention in the elderly with ST-segment elevation myocardial infarction

Therapeutic effects of percutaneous coronary intervention on acute myocardial infarction complicated with multiple organ dysfunction syndrome

Clinical Treatment Efficacy of Percutaneous Coronary Intervention Therapy on Acute Myocardial Infarction Complicated with Multiple Organ Dysfunction Syndrome

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