Primary Pancreatic Leiomyosarcoma: A Rare Malignant Transformation of Primary Pancreatic Head Leiomyoma

Abstract

Primary pancreatic leiomyosarcoma and primary pancreatic leiomyoma are rare tumors of the pancreas. Primary pancreatic leiomyoma is a benign tumor and its conversion to leiomyosarcoma has never been reported. We report a case of malignant transformation of pancreatic leiomyoma. In this case, a 75-year-old male, who presented with a mass in the head of the pancreas, was diagnosed with primary pancreatic leiomyoma. The patient maintained well on symptomatic treatment for 13 years. However, later the patient presented with loss of appetite, significant weight loss, and an abdominal lump, which was diagnosed to be locally advanced primary pancreatic leiomyosarcoma. The patient was provided the best supportive care and died after 11 months of diagnosis. Hence, we conclude that a more radical treatment approach is needed in patients with primary pancreatic leiomyoma.

Gastric Leiomyosarcoma in Post–Gastrointestinal Stromal Tumor Era: Revisit

“…The etiology of stomach leiomyosarcoma remains unclear. Helicobacter pylori may play a role in the development of gastric leiomyosarcoma, 4,5 given its involvement in the pathogenesis of gastric mucosa-associated lymphoid tissue lymphoma and carcinoma. 6 Previous medical histories such as gastroesophageal reflux disease, [7][8][9] gastritis, 10 GI tract leiomyoma, 4,11 gastric adenocarcinoma, 11 retinoblastoma 12,13 with germline mutation in RB1, mantle cell lymphoma, 14 Wilms tumor, 15 obesity, 16,17 colon cancer, gastric polyp, melanoma, and acoustic neuroma 5 have been reported.…”

“…1). 5,25,33 Morphologically, tumors may arise from the muscularis propria 14,[24][25][26] or the muscularis mucosae. 10,13,29,34 These tumors can exhibit well-circumscribed borders, comprised of spindle cells arranged in a fascicular pattern (Fig.…”