Primary Pancreatic Choriocarcinoma Revealed on FDG PET/CT

Rao, Maohua; Chen, Yue; Zhu, Yan; Huang, Zhanwen; Zhang, Li

doi:10.1097/rlu.0000000000000584

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Metastatic choriocarcinoma to organs such as the pancreas, lung or brain has been previously reported. 7,9 This current patient was a rare case of sequential GTN metastasis to the liver and subsequently to the pancreas, which was shown by histopathological examinations to be a PSTT after a long period of disease quiescence. The mass in the body of the pancreas was successfully resected and an additional five cycles of monthly chemotherapy were administered.…”

Section: Discussionmentioning

confidence: 76%

Sequential metastasis to the liver and pancreas 4 years after gestational trophoblastic neoplasia: a case report

et al. 2020

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This case report describes a 43-year-old female initially diagnosed with gestational trophoblastic neoplasia that then experienced metastasis to the liver and then subsequently to the pancreas nearly 4 years after the primary diagnosis. After resection of the body and tail of the pancreas, the postoperative histopathological examination confirmed a placental site trophoblastic tumour that had developed after several cycles of chemotherapy for the original primary tumour and the liver metastases. This type of sequential recurrence of gestational trophoblastic neoplasia in the primary site or metastatic sites, such as the liver or pancreas, can be cured by a comprehensive treatment strategy involving surgery and/or salvage chemotherapy and continuous follow-up over a long period, especially for patients with a high-risk status.

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Section: Discussionmentioning

confidence: 76%

Sequential metastasis to the liver and pancreas 4 years after gestational trophoblastic neoplasia: a case report

et al. 2020

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“…However, a subset of cases has demonstrated low 18 F-FDG accumulation in metastatic nodules from choriocarcinoma, potentially influenced by hemorrhagic and/or necrotic components affecting 18 F-FDG avidity ( 83 ). The reported SUVmax range for choriocarcinoma spans from 2.0 to 27.5, encompassing various studies ( 13 , 16 , 20 , 21 , 23 , 26 , 28 , 30 , 31 , 33 , 36 , 45 – 47 , 49 , 51 , 53 , 54 , 60 – 62 , 64 , 83 ).…”

Section: Discussionmentioning

confidence: 99%

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

Huang,

Zheng,

Bao

et al. 2024

Front. Med.

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BackgroundNon-gestational choriocarcinoma, also known as primary choriocarcinoma, is extremely rare in men, manifesting with specific signs such as breast feminization, testicular atrophy, and loss of libido. The presentation typically includes elevated serum β-hCG levels, widespread metastatic disease, and a rapid progression of the condition.Case reportWe present a rare case of a 41-year-old man diagnosed with choriocarcinoma, exhibiting a unique combination of multiple metastases, including lung, brain, bone, and retroperitoneal lymph node metastases, as confirmed by 18F-FDG PET/CT imaging. The patient was treated with aggressive chemotherapy and pembrolizumab, and the prognosis remained poor. The patient’s overall survival was a mere 5 months following diagnosis.ConclusionNon-gestational choriocarcinoma represents a rare entity in clinical practice and should be considered in young men presenting with gynaecomastia and elevated β-hCG levels alongside normal gonads. Thus, we advocate for a more comprehensive inquiry into medical history and a systematic examination. The 18F-FDG PET/CT examination not only visually delineates the lesion’s location and extent but also serves as a cornerstone for clinical tumor staging, providing valuable support for treatment monitoring and subsequent follow-up.

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“…Overexpression of GLUT-1 and hexokinase-Ⅱ has been reported in PC [23] . In patients with PC, several studies have demonstrated that 18 F-FDG PET/CT was an important key factor for in staging, detecting postoperative recurrence, and evaluating the response to treatment [24][25][26][27][28] . The recent typical researches and interest findings were listed in the follow.…”

Section: F-fluorodeoxyglucosementioning

confidence: 99%

Advancement in treatment and diagnosis of pancreatic cancer with radiopharmaceuticals

Xu¹

2016

WJGO

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Pancreatic cancer (PC) is a major health problem. Conventional imaging modalities show limited accuracy for reliable assessment of the tumor. Recent researches suggest that molecular imaging techniques with tracers provide more biologically relevant information and are benefit for the diagnosis of the cancer. In addition, radiopharmaceuticals also play more important roles in treatment of the disease. This review summaries the advancement of the radiolabeled compounds in the theranostics of PC.

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Primary Pancreatic Choriocarcinoma Revealed on FDG PET/CT

Cited by 9 publications

References 23 publications

Sequential metastasis to the liver and pancreas 4 years after gestational trophoblastic neoplasia: a case report

Sequential metastasis to the liver and pancreas 4 years after gestational trophoblastic neoplasia: a case report

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

Advancement in treatment and diagnosis of pancreatic cancer with radiopharmaceuticals

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