Primary oxalosis of the heart: a cause of heart block.

Coltart, D J; Hudson, Reginald E. B.

doi:10.1136/hrt.33.2.315

Cited by 47 publications

(17 citation statements)

References 8 publications

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“…Discolouration and even gangrene of the affected extremities may result [3,55]. Life-threatening complications are caused by oxalate deposition in the conduction system of the heart [5,16]. In 50% of all patients dying on dialysis the cause of death was sudden untreatable arrhythmias, mainly third degree AV-block [31].…”

Section: Symptoms and Coursementioning

confidence: 99%

Primary hyperoxaluria type I

1990

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Primary hyperoxaluria type I is a metabolic disorder caused by the deficiency of the peroxisomal alanine:glyoxylate aminotransferase. The disease is inherited as an autosomal recessive trait. The clinical course is outlined based on data from 330 published cases. Diagnostic cornerstones are clinical parameters, urinary excretion of oxalate and glycolate, and the determination of enzyme activity in liver tissue. Principles of conservative treatment, e.g. volume load and pyridoxine substitution, are described as well as experience with different modes of dialysis and transplantation. Kidney transplantation is associated with a high rate of recurrence of the original disease despite excellent management resulting in many instances in early graft loss. Liver transplantation offers the possibility to correct the metabolic defect and to prevent the progression of crystal deposition in the body.

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Section: Symptoms and Coursementioning

confidence: 99%

Primary hyperoxaluria type I

1990

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“…There is no known gold standard diagnostic test and without a positive control, no screening test has been developed. Manifestations of oxalosis were often detected based on clinical suspicion [16,[27][28][29][30][31] and we know of no recent reports of secondary oxalosis in ESRD patients on dialysis, even though the vast majority of prevalent HD patients have an abnormal pre-HD P[Ox]. While we cannot conclusively say that our patients did not have secondary oxalosis, this condition may be extremely rare, or even nonexistent.…”

Section: Discussionmentioning

confidence: 70%

Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Yu-guan

Weisberg

Langman

et al. 2016

Clinical Biochemistry

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“…Furthermore, an in vitro study revealed that collagen facilitates formation of CaOx crystals by acting as a matrix [15]. Previously, a case of cardiac fibrosis associated with CaOx deposition was reported in a human patient [5]. Because the present case had fibrosis in the lungs, it was considered that CaOx depositions would be related to development of fibrotic lesions, as a result of abnormal turnover of collagens.…”

mentioning

confidence: 76%

Pulmonary Dystrophic Oxalosis and its Possible Relation to Fibrosis in an Aged Gentoo Penguin (<i>Pygoscelis papua</i>)

Wijesundera

Izawa

Tanaka

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. A 20-year-old Gentoo penguin was found dead with a clinical history of inappetence and dyspnoea. At necropsy, the lungs showed severe congestion/hemorrhage and atelectasis. Histopathologically, fibrosis was observed exclusively around parabronchi with severe collagen deposition. In fibrotic lesions, there were numerous depositions of crystalline structures accompanied by epithelioid cells and multinucleated giant cells (foreign body type). In addition to irregularly lamellar structures as the morphology, the crystals were demonstrated calcium oxalate (CaOx) by the Alizarin red S staining with and without polarized light and von Kossa's staining. Myocobacteria and fungi were not found by special and immuohistochemical stainings. Pulmonary dystrophic oxalosis is a very rare lesion in Gentoo penguin. KEY WORDS: calcium oxalate, dystrophic oxalate, gentoo penguin, lung.

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Primary oxalosis of the heart: a cause of heart block.

Cited by 47 publications

References 8 publications

Primary hyperoxaluria type I

Primary hyperoxaluria type I

Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Pulmonary Dystrophic Oxalosis and its Possible Relation to Fibrosis in an Aged Gentoo Penguin (<i>Pygoscelis papua</i>)

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