Primary ovarian synovial sarcoma

Abstract

Synovial sarcoma (SS) has a rare occurrence in the female genital tract. Only three prior reports of primary ovarian sarcoma could be retrieved after a thorough literature review. We are reporting a case of primary ovarian SS in a young woman. The tumour showed monophasic spindle cell morphology, and there was a wide list of differential diagnosis to consider. We confirmed the diagnosis by cytogenetics Flourescent Insitu Hybridisation (FISH) technique to identify the classical translocation. The diagnosis of this disease can be challenging especially if the tumour is of monophasic type. Morphology and immunohistochemistry are not enough to confirm the diagnosis in many cases. A confirmatory molecular pathology test is paramount. We have discussed the differential diagnosis of spindle cell tumours in ovary. We suggest that SS should be in the differential diagnoses when facing any atypical spindle cell tumour in the ovary. Molecular pathology techniques can help to confirm the diagnosis.

Primary Ovarian Synovial Sarcoma — A Case Report

“…It is subclassified into two subtypes consisting of a biphasic (BPSS) and monophasic spindle cell (MPSS) type [4]. It extremely rarely affects the pelvis, and so far, only 4 cases of primary involvement of the adnexa have been described [5].…”

“…In the other case, the patient was stable 5 months later despite refusing treatment [15]. In one case, despite refusing radical surgical treatment and subsequent chemotherapy and/or radiation therapy, the patient had no evidence of recurrence 27 months later [17].…”