Primary ovarian leiomyosarcoma as a new component in the nevoid basal cell carcinoma syndrome: A case report

Seracchioli, Renato; Colombo, Filippo Maria; Bagnoli, A.; Trengia, Vincenzo; Venturoli, Stefano

doi:10.1067/mob.2003.86

Cited by 30 publications

(39 citation statements)

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“…However, a number of cases have referred to an association between POLMS and fibroma. Seracchioli et al (5) reported the case of a 20-year-old woman exhibiting POLMS, who had suffered from nevoid basal cell carcinoma syndrome at ~1 year old. A total of 4 years prior to the patient's POLMS excision, a number of fibromas containing microcalcification were identified in the left ovary.…”

Section: Discussionmentioning

confidence: 99%

“…Based on previously reported cases, surgery is the preferred treatment choice (1,5). In the present case, although POLMS was removed at an early stage (Ic), as well as being relatively small in size (3 cm in diameter), and a series of elaborately designed therapies was conducted, the patient demonstrated a negative prognosis.…”

Section: A B C D E Fmentioning

confidence: 97%

“…A total of 4 cases occurred in patients <20 years, 3 of whom had suffered from medulloblastoma at the age of 1 year. The details of the fourth patient are unknown (1,5,6,12). The average age of occurrence for all 72 patients was 54.9 years.…”

Section: A B C D E Fmentioning

confidence: 99%

“…Clinically, POLMS requires differentiation with alternative ovarian sarcomas, tumors in other areas of the body and metastasis to the ovary (1,5,8,37). Under normal conditions, ultrasonic inspection is the preferred primary diagnostic method due to its convenience.…”

Section: A B C D E Fmentioning

confidence: 99%

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Synchronous leiomyosarcoma and fibroma in a single ovary: A case report and review of the literature

Deng

Zhao

et al. 2016

Oncology Letters

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Abstract. Primary ovarian leiomyosarcoma (POLMS) is a rare disease. To the best of our knowledge, only 72 cases, including the present case, have been reported in the English literature, while synchronous POLMS and fibroma in a single ovary have not previously been reported at all. In the present study, a 46-year-old premenopausal woman was diagnosed with a mass in the left ovary in 2005. A total of 5 years after the diagnosis of this mass, the patient was admitted to hospital exhibiting lower abdominal pain, and two masses were observed in the left ovary. An exploratory laparoscopy was performed. Frozen section analysis led to a diagnosis of fibroma. Furthermore, the observed second mass was hypothesized to be a malignant form of the original fibroma. A hysterectomy and bilateral salpingo-oophorectomy were performed. Pathological reports following surgery revealed concurrent stage Ic POLMS and fibroma in the left ovary. A total of 13 months after the initial surgery, recurrent leiomyosarcoma was detected. Although the patient underwent multiple cytoreductive surgeries and chemotherapy cycles, as well as interstitial brachytherapy and conventional therapy, a poor state of health ensued. Due to the rarity of POLMS, particularly in combination with ovarian fibroma, the current report presents a detailed overview of the literature and discusses a number of histogenetic and clinical issues.

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Section: Discussionmentioning

confidence: 99%

Section: A B C D E Fmentioning

confidence: 97%

Section: A B C D E Fmentioning

confidence: 99%

Section: A B C D E Fmentioning

confidence: 99%

See 2 more Smart Citations

Synchronous leiomyosarcoma and fibroma in a single ovary: A case report and review of the literature

Deng

Zhao

et al. 2016

Oncology Letters

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“…Rarely, the tumor may be virilizing 41 or renin-secreting. 42,43 Ovarian fibrosarcoma 44 and primary ovarian leiomyosarcoma 45 have also been reported.…”

Section: Ovarian Fibromas and Fibrosarcomasmentioning

confidence: 99%