Primary Ovarian Insufficiency Nationwide Incidence Rate and Etiology Among Israeli Adolescents

Gruber, Noah; Kugler, Shir; Vries, Liat de; Brener, Avivit; Zung, Amnon; Eyal, Ori; Rachmiel, Marianna; Koren, Ilana; Tenenbaum‐Rakover, Yardena; Hershkovitz, Eli; Landau, Zohar; Oren, Meirav; Eliakim, Alon; Zangen, David; German, Alina; Majdoub, Hussein; Mazor-Aronovitch, Kineret; Modan‐Moses, Dalit; Yeshayahu, Yonatan; Naugolni, Larisa; Levy‐Shraga, Yael; Ben‐Ami, Michal; Brill, Gherta; Zuckerman‐Levin, Nehama; Levy‐Khademi, Floris; Avnon-Ziv, Carmit; Tiosano, Dov; Harel, Shira; Kedem, Einat; Segev-Becker, Anat; Shoenfeld, Yehuda; Pinhas‐Hamiel, Orit

doi:10.1016/j.jadohealth.2019.11.315

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…The prevalence of POI in Sweden is 1.9% (90% of cases are non-iatrogenic), whereas in China it is 2.75% [1,3]. The study conducted in Israel states that the incidence rate of new POI diagnoses per 100,000 person/year doubled (4.5 vs 2.0) during the years 2009-2016, compared with 2000-2008, which may explain the difference in prevalence between past and up-to-date studies [4].…”

Section: Epidemiologymentioning

confidence: 95%

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Fresh insight into premature ovarian insufficiency

et al. 2021

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Premature ovarian insufficiency (POI) is one of the vital reasons of anovulatory infertility among women under 40 years old. However, because of the unacknowledged causative factor in most cases, it still remains a huge challenge in gynecology. Recently, the most promising opportunities in diagnosing are connected with the use of some serum biomarkers, such as interleukin-17 (IL-17), Frizzled-5 protein, Soggy-1 protein and other cytokines. Additionally, environmental toxicants such as chemicals and heavy metals might be relevant in the near future when investigating the causes of premature ovarian insufficiency. One of the main aims of the therapy is to focus on maintaining fertility among women with POI, since it is essential for patients considering their young age. Among the newest approaches listed there are different types of stem cells, oocytes donation and in-vitro activation, all of which are recently gaining in importance.

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Section: Epidemiologymentioning

confidence: 95%

“…Environmental impact is included in causative factors of POI as well [5,6]. Incidence rates of idiopathic POI have increased by 2.6-fold and other etiologies by 3.0-fold, while the incidence of genetic disorders such as Turner's syndrome remained constant during the years 2009-2016, compared with 2000-2008 [4].…”

Section: Etiologymentioning

confidence: 99%

Fresh insight into premature ovarian insufficiency

et al. 2021

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“…Потеря функции яичников вызывает бесплодие и симптомы менопаузы, а также повышает риск различных заболеваний, таких как остеопороз и сердечно-сосудистые заболевания [32]. Согласно литературным данным, преждевременная и ранняя менопауза поражает примерно 1% женщин [33,34]. С преждевременной и ранней менопаузой связаны различные этиологические факторы, включая токсины окружающей среды, генетические и хромосомные нарушения, а также ятрогенные и аутоиммунные причины [34].…”

Section: Medical Science Of Uzbekistanunclassified

“…Согласно литературным данным, преждевременная и ранняя менопауза поражает примерно 1% женщин [33,34]. С преждевременной и ранней менопаузой связаны различные этиологические факторы, включая токсины окружающей среды, генетические и хромосомные нарушения, а также ятрогенные и аутоиммунные причины [34]. Х-хромосомные дефекты, такие как синдром Тернера и премутация Fragile X, являются наиболее известными генетическими факторами, но все чаще сообщается о специфических аутосомных мутациях.…”

Section: Medical Science Of Uzbekistanunclassified

Клинико-Патогенетические Аспекты Преждевременной И Ранней Менопаузы. Пути Коррекции

Набиева¹,

Каюмова²,

Мухитдинова³

2022

MSU

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В настоящее время проблема ранней и преждевременной менопаузы остается актуальной в связи с потерей фертильности, репродуктивной функции и снижения качества жизни молодых женщин. Определение клинико-гормональных предикторов развития ранней/преждевременной менопаузы и разработка лечебно-диагностического алгоритма ведения женщин даёт возможность улучшения их качества жизни.

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“…While there is an expanding body of evidence indicating an elevated relative risk of diabetes, ischemic heart disease, atherosclerosis, hypertension, and obesity in individuals with TS [7][8][9][10][11], the specific prevalence and contributing risk factors for MetS in this population remain subjects of ongoing investigation. Moreover, the utilization of recombinant human growth hormone (rhGH) and hormone replacement therapy (HRT) in young females with TS adds complexity to predicting their effects on metabolic status [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Are Young People with Turner Syndrome Who Have Undergone Treatment with Growth and Sex Hormones at Higher Risk of Metabolic Syndrome and Its Complications?

Krzyścin,

Sowińska-Przepiera,

Gruca-Stryjak

et al. 2024

Biomedicines

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Introduction: Metabolic syndrome (MetS), characterized by visceral obesity, glucose abnormalities, hypertension and dyslipidemia, poses a significant risk of diabetes and cardiovascular disease. Turner syndrome (TS), resulting from X chromosome abnormalities, carries health complications. Despite growing evidence of an increased risk of MetS in women with TS, its prevalence and risk factors remain under investigation. These considerations are further complicated by the varying timing and dosages of treatment with growth hormone and sex hormones. Methods: We conducted a cross-sectional study comparing 44 individuals with TS with 52 age-matched control subjects. Growth hormone treatment in the study group was administered for varying lengths of time, depending on clinical response. We collected anthropometric, metabolic, endocrine and body composition data. Statistical analyses included logistic regression. Results: Baseline characteristics, including age, BMI and height, were comparable between the TS and control groups. Hormonally, individuals with TS showed lower levels of testosterone, DHEA-S, and cortisol, as well as elevated FSH. Lipid profiles indicated an atherogenic profile, and the body composition analysis showed increased visceral adipose tissue in those with TS. Other metabolic abnormalities were common in individuals with TS too, including hypertension and impaired fasting glucose levels. The risk of MetS components was assessed in subgroups according to karyotypes: monosomy 45X0 vs. other mosaic karyotypes. Logistic regression analysis showed a significant association between increased visceral adipose tissue in subjects with TS. Those with metabolic complications tended to have less muscle strength compared to those without these complications in both the study and control groups. Conclusions: This study highlights the unique metabolic and cardiovascular risk profile of individuals with TS, characterized by atherogenic lipids, higher levels of visceral adipose tissue and increased metabolic abnormalities. These findings underscore the importance of monitoring metabolic health in individuals with TS, regardless of age, BMI or karyotype, and suggest the potential benefits of lifestyle modification, building more muscle strength, and weight control strategies. Further research is needed to better understand and address the metabolic challenges faced by women with TS.

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Primary Ovarian Insufficiency Nationwide Incidence Rate and Etiology Among Israeli Adolescents

Cited by 10 publications

References 30 publications

Fresh insight into premature ovarian insufficiency

Fresh insight into premature ovarian insufficiency

Клинико-Патогенетические Аспекты Преждевременной И Ранней Менопаузы. Пути Коррекции

Are Young People with Turner Syndrome Who Have Undergone Treatment with Growth and Sex Hormones at Higher Risk of Metabolic Syndrome and Its Complications?

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