Primary ovarian carcinoid in mature cystic teratoma: A rare entity

Sharma, Ravi; Biswas, Biswajeet; Wahal, Shailja Puri; Sharma, Neelam; Kaushal, Vijay

doi:10.4103/2278-0513.125803

Cited by 10 publications

(16 citation statements)

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“…The occasion of a carcinoid tumor arising from MCT is very rare with a very small number CURR GYNECOL ONCOL 2016, 14 (3), p. 168-173 DOI: 10.15557/CGO.2016.0020 of published cases (3) . Carcinoid tumors constitute only 0.3% of all ovarian neoplasms; thus they may remain undiagnosed until the time of surgery (1) . Primary ovarian carcinoid is probably more frequent than it has been reported (4) .…”

Section: Case Historymentioning

confidence: 99%

“…Primary ovarian carcinoid is probably more frequent than it has been reported (4) . Carcinoid tumor can be seen in the ovary as a metastasis of a primary tumor located in the gastrointestinal tract or elsewhere, as a component of mature cystic teratoma or as a primary pure neoplasm of this organ (1) . The large majority of primary ovarian carcinoids are unilateral, but in 16% of cases the contralateral ovary is involved by a cystic teratoma or a mucinous neoplasm (5) .…”

Section: Case Historymentioning

confidence: 99%

“…The additional presence of teratoma or other surface epithelial tumors, an absence of blood vessels or lymphatic invasion, and confinement to single ovary, as seen in our case, strongly supports a primary ovarian origin (8) . The prognosis in primary carcinoid (whether pure or a component of mature cystic teratoma) is very good, whereas metastatic carcinoids have poor outcome (1) . Talerman divided primary ovarian carcinoid tumors into four types: the insular type, trabecular type, strumal carcinoid and mucinous type (9) .…”

Section: Case Historymentioning

confidence: 99%

“…Persistent systemic exposure to large quantities of these hormones and biogenic amines can result in carcinoid syndrome, the classical triad of flushing of upper extremities and face, wheezing, and diarrhea. Usually, systemic exposure does not occur with an intestinal carcinoid until it has metastasized, because of efficient hepatic metabolism of secreted substances (1) . However, primary ovarian carcinoid tumors can cause these symptoms directly, because their venous drainage bypasses the portal venous system.…”

Section: Case Historymentioning

confidence: 99%

“…rimary ovarian carcinoids are rare, accounting for 0.3% of all carcinoid tumors (1) . In 1939, Stewart et al reported the first case of carcinoid tumor arising in an ovarian teratoma (2) .…”

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confidence: 99%

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Pierwotny rakowiak jajnika w obrębie dojrzałego potworniaka torbielowatego

Sahu

Agasti

Senapati

2016

Curr. Gynecol. Oncol.

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Primary carcinoid tumor of the ovary in association with a mature cystic teratoma is very rare. Preoperative diagnosis of this tumor is difficult, particularly in the absence of symptoms of carcinoid syndrome. Here, we report a case of a premenopausal woman who underwent operative treatment due to an ovarian mass. The ovary was cystic with a solid mural nodule. Microscopically, the cyst wall revealed features of mature teratoma while the nodule showed features of a low-grade insular carcinoid. Synaptophysin and CD56 were positive. Ki67 index was low. No evidence of primary gastrointestinal or respiratory malignancy was found. The histologic and immunohistochemical characteristics of this tumor, its intimate association with a mature cystic teratoma and the absence of primary malignancy elsewhere were compatible with the diagnosis of a primary ovarian insular carcinoid tumor. This case is reported to raise the awareness of a rare tumor entity among the pathology and gynecologic communities.

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Section: Case Historymentioning

confidence: 99%