Primary osteosarcoma of the skull

Abstract

Primary osteogenic sarcoma of the skull is an exceedingly rare condition. An adult male patient is described, who had a painless swelling in the right forehead that had rapidly enlarged in the previous 6 months. Radiological investigations showed a large destructive mass lesion involving the right side of the frontal bone with extension into the frontal sinus, causing marked extradural compression of brain parenchyma. Histopathological examination confirmed the lesion to be primary osteogenic sarcoma.

Osteosarcoma of the cranial vault and skull base in pediatric patients

“…7,12 Metastatic spread to the brain is uncommon, but when it does occur it is usually a late event, often after multiple recurrences, and is associated with poor survival. 3,32,49 Metastasis to the skull from a distant primary tumor is also uncommon and presents a unique treatment consideration. The current survival rate for children with localized osteosarcoma is approximately 65%, compared with 25% for patients with metastatic disease.…”

“…51 Unlike long bone lesions, however, craniofacial tumors are frequently painless or only mildly tender. 32,51,59 Common presenting symptoms include headache, cranial nerve palsies, exophthalmos, and visual impairment. 22,51 Elevation of the serum alkaline phosphatase level is common, although not uniformly observed.…”

“…38 Tumors arising secondary to a pathological process are typically more aggressive and have higher recurrence rates than those arising de novo. 54,59 Malignancy resulting from these predisposing factors is also more likely to appear at a more advanced age, 32 contributing to the low incidence of cranial osteosarcoma in the pediatric population. 32,33,59 Traumatic injury has also been implicated in the development of osteosarcoma.…”

“…54,59 Malignancy resulting from these predisposing factors is also more likely to appear at a more advanced age, 32 contributing to the low incidence of cranial osteosarcoma in the pediatric population. 32,33,59 Traumatic injury has also been implicated in the development of osteosarcoma. 41 We report our experience treating cranial osteosarcoma in three 14-year-old boys and review the available literature regarding the management of these rare, aggressive tumors.…”

Ekstraaksiyel Beyin Tumorleri

“…Primer veya sekonder olabilir. Sekonder osteosarkom Paget hastalığı, fibröz displazi, kronik osteomiyelit zemininde gelişebileceği gibi radyoterapi sonrası da görülebilir [204,205]. Yaklaşık yarısında histolojik alt tip osteoblastiktir.…”