Primary Osteosarcoma of Left Atrium: Complete Surgical Excision

Marvasti, Mehdi A.; Bove, Edward L.; Obeid, Anis I.; Bowser, Michael A.; Parker, Frederick B.

doi:10.1016/s0003-4975(10)60079-3

Cited by 16 publications

(5 citation statements)

References 6 publications

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“…There is no evidence that primary cardiac osteosarcomas represent malignant transformation of benign tumors, despite the fact that both osteosarcoma and benign tumor are often found in the left atrium [9,11]. The tumor's cell of origin has yet to be clearly identified.…”

Section: Discussionmentioning

confidence: 99%

A primary cardiac osteosarcoma: Case report and review of the literature

Aguilar

Donet

Galarreta

et al. 2013

Journal of Cardiology Cases

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Primary cardiac osteosarcoma is a rare and aggressive neoplasm that can be difficult to diagnose. We report a case of a previously healthy 49-year-old woman who presented with dyspnea, atrial flutter, and heart failure. A mass was visualized in her left atrium by echocardiography and cardiac computed tomography, and the diagnosis of cardiac myxoma was raised. The patient subsequently underwent surgical resection of the mass and atrial reconstruction. Surprisingly, histological and immunohistological analyses revealed the mass to be an osteosarcoma. The patient received chemotherapy and radiotherapy. Eight months later, she has shown evidence of local recurrence. We briefly discuss primary osteosarcomas in the cardiac cavity and their management.

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Section: Discussionmentioning

confidence: 99%

A primary cardiac osteosarcoma: Case report and review of the literature

Aguilar

Donet

Galarreta

et al. 2013

Journal of Cardiology Cases

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“…Marvasti et al [84] reported a LA resection in a patient with osteogenic sarcoma, who subsequently required a pneumonectomy as a separate procedure.…”

Section: Left Atrial (La) and Pulmonary Vein (Pv) Sarcomasmentioning

confidence: 99%

Primary cardiac sarcoma

Shanmugam¹

2006

European Journal of Cardio-Thoracic Surgery

132

157

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Primary malignant lesions of the heart are rare. Although myxomas have been extensively described, there is a paucity of large studies on non-myxomatous cardiac tumours. On the other hand, there are several case reports on specific histopathological variants, in small numbers. Consequently there exists no consensus on therapeutic modalities for cardiac sarcomas. The prognosis for these lesions remains dismal, despite the enhanced diagnostic ability of newer technology. The reasons for the dismal prognosis are (1) the advanced tumour stage at presentation, (2) non-specific symptomatolgy, (3) insufficient awareness of these lesions, due to their rarity, (4) delayed diagnosis and/or misdiagnosis, which leads to (5) advanced tumour stage at presentation. Thus a vicious cycle is created. This article addresses these issues, deals with the surgically relevant modes of presentation, rather than the histopathology, and reviews the diagnosis and management options for the various sarcomas, categorized by the site and extent of cardiac involvement. Clinicians should be familiar with the presentation of these tumours and have a high index of suspicion, since the potential for long-term survival following resection does exist. Wide surgical resection remains the cornerstone of sarcoma therapy. Complete characterization of tumour extent using echocardiography and CT/MRI is mandatory to achieve this goal. Radical resections such as 'bench surgery' and transplantation may reduce local recurrence, but the risk of metastatic disease remains. The clinical experience with such approaches is limited. The role of adjuvant therapy is not yet established. In no other field of cardiac surgery would a multidisciplinary approach be more useful, in achieving cure or long-term palliation.

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“…This makes surgery the first therapeutical procedure in most cases. Complete excision is associated with better survival and becomes the main prognostic factor in nonmetastatic primary cardiac osteosarcoma [8].…”

Section: Discussionmentioning

confidence: 99%

Primary cardiac osteosarcoma

et al. 2008

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Primary cardiac neoplasms are an infrequent disease, as most of the tumors arising in the heart are metastatic. Between the malignant tumors, sarcomas are the most frequent ones, accounting for at least 95% of them. We report the case of a 70-year old woman, diagnosed of primary cardiac osteosarcoma arising in the left atrium. Although complete excision of the tumor was performed, the disease relapsed and subsequently developed metastatic disease. In this paper, we also review briefly the management of this rare disease and the therapeutic options.

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Primary Osteosarcoma of Left Atrium: Complete Surgical Excision

Cited by 16 publications

References 6 publications

A primary cardiac osteosarcoma: Case report and review of the literature

A primary cardiac osteosarcoma: Case report and review of the literature

Primary cardiac sarcoma

Primary cardiac osteosarcoma

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