Primary osteosarcoma of frontal bone

Wu, Guangyong; Qi, Liang; Liu, Yu

doi:10.1097/md.0000000000009392

Cited by 18 publications

(10 citation statements)

References 41 publications

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“…The effect of radiotherapy after resections with positive margins still remains to be investigated [ 21 , 23 ]. Dural involvement is not uncommon and in cases with dural involvement, the dura needs to be resected [ 23 , 29 , 50 ]. Although wide surgical margins seem to improve survival [ 17 , 36 ], this is commonly difficult to achieve because of adjacent critical structures [ 22 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis

et al. 2018

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Background Common primary bone tumors include osteosarcomas (OSC) and Ewing sarcomas (EWS). The skull is a rare site, and literature about their treatment and survival is scarce. Using the Surveillance, Epidemiology, and End Results (SEER) database, this study aims to assess the treatment and survival of skull OSC and skull EWS, as well as predictors for survival. Methods Skull OSC and EWS cases were obtained from the SEER database. Patient and tumor characteristics, treatment modalities, and survival were extracted. Overall survival (OS) was assessed using multivariable Cox proportional hazard regression stratified by tumor histology. Kaplan-Meier curves were constructed for OS comparing OSC and EWS, as well as histological subtypes in OSC. Results A total of 321 skull OSC and 80 skull EWS patients were registered from 1973 to 2013. EWS was more common in younger patients ( p < 0.001). Resection was the predominant treatment strategy (80.1%), frequently in combination with adjuvant radiotherapy (30.4%). The 5-year survival rate varied significantly between OSC and EWS (51.0% versus 68.5%, p = 0.02). Kaplan-Meier curves show that EWS had a significantly better survival compared to OSC. Comparing histological subtypes of skull OSC, chondroblastic OSC had the best OS, Paget OSC the worst. Older age, tumor advancement, no surgical treatment, and the use of radiotherapy were identified as independent predictors of decreased OS in skull OSC. Conclusion Overall prognosis is better for EWS compared to OSC. Chondroblastic OSC have the best overall survival, while OSC associated with Paget’s disease of the bone has the poorest overall survival.

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Section: Discussionmentioning

confidence: 99%

Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis

et al. 2018

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“…Therefore, when it is suspected, it is probably secondary, and "pagetic" or irradiated bone nearby should be sought (Fig. 11) [39].…”

Section: Osteosarcomamentioning

confidence: 99%

Imaging of skull vault tumors in adults

et al. 2020

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The skull vault, formed by the flat bones of the skull, has a limited spectrum of disease that lies between the fields of neuro-and musculoskeletal radiology. Its unique abnormalities, as well as other ubiquitous ones, present particular features in this location. Moreover, some benign entities in this region may mimic malignancy if analyzed using classical bone-tumor criteria, and proper patient management requires being familiar with these presentations. This article is structured as a practical review offering a systematic diagnostic approach to focal calvarial lesions, broadly organized into four categories: (1) pseudolesions: arachnoid granulations, meningo-/encephaloceles, vascular canals, frontal hyperostosis, parietal thinning, parietal foramina, and sinus pericrani; (2) lytic: fibrous dysplasia, epidermal inclusion and dermoid cysts, eosinophilic granuloma, hemangioma, aneurysmal bone cyst, giant cell tumor, metastasis, and myeloma; (3) sclerotic: osteomas, osteosarcoma, and metastasis; (4) transdiploic: meningioma, hemangiopericytoma, lymphoma, and metastasis, along with other less common entities. Tips on the potential usefulness of functional imaging techniques such as MR dynamic susceptibility (T2*) perfusion, MR spectroscopy, diffusion-weighted imaging, and PET imaging are provided.

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“…Also, primary osteosarcomas of the skull and skull baseare quite rare, comprising < 2% of all skull tumors. Besides, primary osteosarcoma of the spine is rare, accounting for 3–5% of all osteosarcomas [ 27 , 28 ]. Ewing’s sarcoma occurs mostly in children who were excluded from the study population.…”

Section: Limitationsmentioning

confidence: 99%

Economics of the Management of Craniospinal Chordoma and Chondrosarcoma and the feasibility of the bundled payment model

et al. 2020

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Background: The Centers for Medicare and Medicaid Services (CMS) created a new reimbursement model "Bundled Payment for Care Improvement (BPCI)" which reimburses providers a predetermined payment in advance to cover all possible services rendered within a certain time window. Chordoma and Chondrosarcoma are locally aggressive malignant primary bony tumors. Treatment includes surgical resection and radiotherapy with substantial risk for recurrence which necessitates monitoring and further treatment. We assessed the feasibility of the BPCI model in these neurosurgical diseases. Methods: We selected patients with chordoma/chondrosarcoma from inpatient admission table using the International Classification of Disease, 9th (ICD-9), and 10th (ICD-10) revision codes. We collected the patients' demographics and insurance type at the index hospitalization. We recorded the following outcomes length of stay, total payment, discharge disposition, and complications for the index hospitalization. For post-discharge, we collected the 30 days and 3/6/12 months inpatient admission, outpatient service, and medication refills. Continuous variables were summarized by means with standard deviations, median with interquartile and full ranges (minimum-maximum); Continuous outcomes were compared by nonparametric Wilcoxson rank-sum test. All tests were 2-sided with a significance level of 0.05. Statistical data analysis was performed in SAS 9.4 (SAS Institute, Inc, Cary, NC). Results: The population size was 2041 patients which included 1412 patients with cranial (group1), 343 patients with a mobile spine (group 2), and 286 patients with sacrococcygeal (group 3) chordoma and chondrosarcoma. For index hospitalization, the median length of stay (days) was 4, 6, and 7 for groups 1, 2, and 3 respectively (P<.

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Primary osteosarcoma of frontal bone

Cited by 18 publications

References 41 publications

Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis

Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis

Imaging of skull vault tumors in adults

Economics of the Management of Craniospinal Chordoma and Chondrosarcoma and the feasibility of the bundled payment model

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