Primary osteosarcoma distal to the antebrachiocarpal and tarsocrural joints in nine dogs (1980-1992)

Abstract

The medical records of nine dogs with primary osteosarcoma distal to the antebrachiocarpal or tarsocrural joint were reviewed. Eight of the nine dogs were treated with surgical removal of the primary tumor; seven received adjuvant chemotherapy; and one dog was treated with chemotherapy alone. Median survival of dogs in this series was 466 days. Six of the nine dogs died of causes attributable to osteosarcoma, and both skeletal and pulmonary metastases occurred. Survival of dogs with osteosarcoma distal to the antebrachiocarpal or tarsocrural joint was somewhat longer than survival of dogs with osteosarcoma of more common appendicular sites. However, these are aggressive tumors with a high potential for metastasis.

Intraosseous Transcutaneous Amputation Prosthesis (ITAP) for Limb Salvage in 4 Dogs

“…Other appendicular malignancies, especially those involving joints such as synovial cell sarcoma, present a similar therapeutic challenge, albeit that postexcision survival time may be superior to OSA . Limb amputation is reported to be the gold standard treatment for local disease in dogs with primary bone and joint tumors …”

“…Reconstructive limb salvage procedures (by comparison with ablative limb salvage procedures), to the best of the our knowledge, have been largely limited to the treatment of long bones. Malignant tumors involving the carpus and/or metacarpus may represent a substantial therapeutic challenge because of the relatively complex osseous anatomy and limitations of conventional reconstructive limb salvage procedures …”

Intercalary Bone Grafts for Joint and Limb Preservation in 17 Dogs with High‐Grade Malignant Tumors of the Diaphysis

“…The MST of 449 days for dogs with diaphyseal OSA treated with intercalary limb‐sparing surgery and, in all but 1 dog, adjuvant chemotherapy is numerically superior to historical reports of 235–366 days for dogs managed with limb amputation or salvage and postoperative chemotherapy 2–4,42–51 . The prognosis for dogs with diaphyseal OSA may be better than metaphyseal sites, similar to dogs with OSA distal to the carpus and tarsus, 52 although this is difficult to conclude based on the small sample population and difficulty in comparing results with other retrospective studies. Regardless, diaphyseal OSA remains an aggressive tumor with a high metastatic rate.…”

A Dog in the Cancer Fight: Comparative Oncology in Osteosarcoma

“…Survival time of dogs with OSA distal to the antebrachiocarpal (equivalent of human wrist) or tarsocrural joints (human ankle) has a median survival time of 466 days, which is longer than the survival time of dogs with OSA of more common appendicular sites. However, OSA of these sites is aggressive, with a high potential for metastasis [50]. Extraskeletal OSA has an aggressive systemic behavior with a high metastatic rate, with short median survival times ranging from 1 month to 5 months [27,28].…”