Primary osteogenic sarcoma of the vertebral column. A clinicopathologic correlation of ten patients

Barwick, Kenneth W.; Huvos, Andrew G.; Smith, Julius

doi:10.1002/1097-0142(19800801)46:3<595::aid-cncr2820460328>3.0.co;2-8

Cited by 113 publications

(67 citation statements)

References 19 publications

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“…2,3,5,24,25 Primary osteosarcoma of the spine accounts for 1.2% of all patients in this series, which is very similar to previous reports. 3,4,24 Twenty of 22 patients had pain, and 12 of 22 patients had a neurologic deficit.…”

Section: Discussionsupporting

confidence: 90%

“…There are only a few reports on long-term survivors of spinal osteosarcoma after receiving chemotherapy with 3 or without radiation therapy. 15 In general, however, the effect of chemotherapy is only temporary, and preoperative chemotherapy should be followed by intensive local treatment.…”

Section: Discussionmentioning

confidence: 99%

“…3,5,7 In recent years, aggressive adjuvant and neoadjuvant chemotherapy has improved the treatment outcome of patients with osteosarcoma. 3,5,8 -11 There have been several articles on the treatment of patients with osteosarcoma of the spine; 3,5,12 however, those publica-tions included patients who were treated over a 30-year or 40-year period under different concepts of treatment 3,5 or were a type of case report 6,[13][14][15][16] because of the rarity of spinal or sacral osteosarcomas.…”

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confidence: 99%

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Osteosarcoma of the spine

Ozaki

Flege

Liljenqvist

et al. 2002

Cancer

235

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BACKGROUNDDue to the low incidence rate, the optimal strategy for the treatment of patients with spinal osteosarcoma is unknown.METHODSTwenty‐two patients with osteosarcoma of the spine (15 with tumors of the sacrum and 7 with tumors at other sites) who received chemotherapy according to the Cooperative Osteosarcoma Study Group protocol were analyzed. Six patients presented with metastasis, and 16 patients had no evidence of metastasis at the time of entry into the protocol. Of 12 patients who underwent excision of their tumors, 2 patients underwent wide excision, 3 patients underwent marginal excision, and 7 patients underwent intralesional excision. Eight patients received irradiation: Six patients received conventional radiotherapy only, one patient received neutron beam therapy, and one patient received samarium‐153‐ethylene diamine tetramethylene phosphonate therapy. Follow‐up ranged between 24 months and 105 months (median, 47 months).RESULTSThe median survival was 23 months, and three patients have survived without disease for > 6 years. Patients with primary metastases (P = 0.004), large tumors (P = 0.010), and sacral tumors (P = 0.048) had lower overall survival compared with patients who had no metastasis, small tumors, and nonsacral tumors, respectively. There was a significant difference in overall survival between 5 patients who underwent either wide or marginal surgery and 17 patients who underwent either intralesional surgery or no surgery (P = 0.033). Among 17 patients who underwent no surgery or intralesional surgery, overall survival tended to be better in 7 patients who received irradiation compared with the overall survival in 10 patients who did not receive irradiation (P = 0.059).CONCLUSIONSPatients with metastases, a large tumors, and sacral tumors had a poor prognosis in the current study with small numbers of patients. Wide or marginal excision of the tumor improved survival. Patients with osteosarcoma of the spine should be treated with a combination of chemotherapy and at least marginal excision for those with surgically accessible tumors. Postoperative radiotherapy may be beneficial. Cancer 2002;94:1069–77. © 2002 American Cancer Society.DOI 10.1002/cncr.10258

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Osteosarcoma of the spine

Ozaki

Flege

Liljenqvist

et al. 2002

Cancer

235

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“…[3][4][5][6] Osteosarcoma is a malignant bone tumor that frequently affects patients in their second and third decades of life, however, it is reported there exists two peaks in the incidence of osteosarcoma, one is in the second decade and another in the seventh decade of life. 7 Huvos 8 reported three cases of osteosarcoma of the spine among 117 patients with osteosarcoma older than 60 years.…”

Section: Introductionmentioning

confidence: 99%

Primary osteosarcoma of the thoracic spine: report of an unusual elderly patient with autopsy findings

et al. 2005

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“…3 It tends to occur in a slightly older age group, with a mean age of 38 years, 4 than osteosarcoma of the extremity. 3,5,6 It has been found that the prognosis for patients with osteosarcoma of the trunk is worse compared with the prognosis of patients with osteosarcoma of the extremities. 3,5,7 In recent years, aggressive adjuvant and neoadjuvant chemotherapy has improved the treatment outcome of patients with osteosarcoma.…”

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confidence: 99%