Primary osseous rhabdomyosarcoma with focal matrix formation mimicking osteosarcoma

Kordek, Radzisław; Sowa, Piotr; Panasiuk, Michał; Kmieciak, Marek; Chudobiński, Cezary; Płuciennik, Elżbieta; Potemski, Piotr; Jesionek-Kupnicka, Dorota

doi:10.1016/j.prp.2007.08.003

Cited by 5 publications

(10 citation statements)

References 24 publications

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“…Primary rhabdomyosarcomas of bone are exceedingly rare, with fewer than 10 credible reported cases of osseous rhabdomyosarcomas of embryonal, alveolar or pleomorphic subtype . There is one report, by Oda and colleagues, of a primary rhabdomyosarcoma of the iliac bone in an adult (described as resembling ‘fibrosarcoma’), which appears to us to most probably represent spindle cell rhabdomyosarcoma …”

Section: Discussionmentioning

confidence: 99%

Spindle cell rhabdomyosarcoma of bone with FUS–TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Spindle cell rhabdomyosarcoma of bone with FUS–TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype

et al. 2018

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“…Pathological fracture is frequently found on bone rhabdomyosarcoma. We found 14 cases (7,(9)(10)(11)16,18,19) evolved with pathological fracture after or during diagnostic investigation. In all of these cases, the tumor was present in the femur, four diaphyseal (7,11,16,17) and one located in the distal region of the femur.…”

Section: Discussionmentioning

confidence: 93%

“…We found 14 cases (7,(9)(10)(11)16,18,19) evolved with pathological fracture after or during diagnostic investigation. In all of these cases, the tumor was present in the femur, four diaphyseal (7,11,16,17) and one located in the distal region of the femur. (9) The most common locations for intraosseous RMS are femoral diaphysis.…”

Section: Discussionmentioning

confidence: 93%

“…The literature review has shown few reports of primary bone RMS. (1,7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) Of the fifteen cases presented so far (including this one), two did not have a specified subtype and one of them did not give access to full data (Table 2). The ERMS and ARMS subtypes were concentrated in younger patients while all pleomorphic subtypes were diagnosed in patients over 30-years-old.…”

Section: Discussionmentioning

confidence: 99%

“…involvement of bone. (1,5,10) Other cases reported showed up on the distal femur, (9) proximal femur, (18) proximal fibula, (11) sacrum, (6) iliac, (14) and humerus. (17) Osteolytic lesions were the main pattern, (2,11,17) followed by permeated infiltration, eventually associated with some soft tissue component.…”

Section: Ki-67mentioning

confidence: 99%

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Femoral intraosseous rhabdomyosarcoma: a case report and literature review

Viola¹,

Oliveira²,

Garcia³

et al. 2021

BJOncology

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Introduction: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood.However, primary bone rhabdomyosarcoma is a rare entity with some few cases reported.Case Report: We present a case of a 19-year-old female patient referred from another service with three months history of a bone tumor on the femur. The first anatomopathological study was consistent with high-grade osteogenic sarcoma. After revision exams and analysis of surgically resected tumor, the primary osseous rhabdomyosarcoma was confirmed. The patient had undergone tumor resection and reconstruction with mega prosthesis. After surgery, she received chemotherapy following rhabdomyosarcoma protocol. Conclusion:Primary osseous rhabdomyosarcoma is a rare but important differential diagnosis to be thought on atypical presentation of primary bone sarcomas.

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Invasive spindle-cell rhabdomyosarcoma with osteolysis in a dog: case report and literature review

et al. 2023

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Rhabdomyosarcoma (RMS), a malignant mesenchymal neoplasm derived from skeletal muscle, is relatively rare in both human and veterinary medicine. Here we report an unusual case of invasive spindle-cell RMS (SCRMS) with bone infiltration and pathologic fracture in a 3.5-y-old intact female Bulldog. Radiographically, a large, predominantly osteolytic mass in the tibia and fibula of the left hindlimb had features typical of a malignant primary bone tumor. Clinically, osteosarcoma was suspected, and the leg was amputated. Histologically, the mass was composed of loosely interwoven spindle-cell fascicles; tumor cells were fusiform with cigar-shaped nuclei and abundant eosinophilic cytoplasm. The neoplastic cells were strongly immunopositive for vimentin, muscle-specific actin, desmin, myogenin, and myoD1. Invasive SCRMS with osteolysis was diagnosed based on the histologic examination and immunohistochemical (IHC) stains. The dog was alive without any evidence of local recurrence or distant metastasis 18 mo post-surgery. RMS should be included in the differential diagnosis when osteolysis occurs; IHC staining confirmation is of great value for definitive diagnosis and treatment planning.

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Primary osseous rhabdomyosarcoma with focal matrix formation mimicking osteosarcoma

Cited by 5 publications

References 24 publications

Spindle cell rhabdomyosarcoma of bone with FUS–TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype

Spindle cell rhabdomyosarcoma of bone with FUS–TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype

Femoral intraosseous rhabdomyosarcoma: a case report and literature review

Invasive spindle-cell rhabdomyosarcoma with osteolysis in a dog: case report and literature review

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