Primary orthostatic tremor: is deep brain stimulation better than spinal cord stimulation?

Chiang, Han‐Lin; Tai, Yi‐Cheng; McMaster, Jacqueline; Fung, Victor S.C.; Mahant, Neil

doi:10.1136/jnnp-2016-315188

Cited by 10 publications

(13 citation statements)

References 5 publications

(4 reference statements)

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“…Investigators have sought to localize the CON using neuroimaging and neurostimulation. Candidate brain regions include primary motor cortex (PMC), supplementary motor area (SMA), cerebellum, thalamus, and pontine tegmentum [ 6 , 7 , 8 , 15 , 16 , 17 , 18 , 19 , 20 ]. A neuroimaging study using resting-state functional MRI (rs-fMRI) reported that individuals with OT exhibited increased connectivity between the SMA and cerebellum [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…A neuroimaging study using resting-state functional MRI (rs-fMRI) reported that individuals with OT exhibited increased connectivity between the SMA and cerebellum [ 6 ]. Meanwhile, neurostimulation of PMC, spinal cord, and thalamus have been reported to affect OT signs [ 7 , 8 , 15 , 16 , 20 ]. While prior work has identified characteristics of the CON, much remains to be determined, including the functional connectivity of its elements and potential associations with demographic and disease variables.…”

Section: Introductionmentioning

confidence: 99%

“…Here, we studied the putative CON by measuring the intrinsic functional brain connectivity of individuals with OT ( n = 13) using non-invasive neuroimaging and neurostimulation methods. Specifically, we used rs-fMRI to measure RSFC between brain regions comprising the putative CON [ 7 , 8 , 15 , 16 , 20 ]. Regions of interest (ROIs) included primary motor cortex (PMC); supplementary motor area (SMA); cerebellum; ventralis intermedius of the thalamus (VIM); and pontine tegmentum (PT).…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor

Phipps,

Whitney,

Shou

et al. 2024

Brain Sciences

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Orthostatic tremor is a rare movement disorder characterized by a sensation of unsteadiness and leg tremor while standing. It has been hypothesized that the disorder is attributable to dysregulation of a central oscillatory network in the brain. This putative network includes primary motor cortex, supplementary motor area, cerebellum, thalamus, and pontine tegmentum. We studied this brain network by recording resting-state functional MRI data from individuals with orthostatic tremor. For each participant, we measured resting-state functional connectivity using a seed-based approach. Regions of interest included were components of the putative central oscillatory network and a primary motor thumb region (identified via transcranial magnetic stimulation). A non-central oscillatory network region of interest—posterior cingulate cortex—was included for comparative analysis of a well-characterized intrinsic network, the default mode network. Demographic information, medical history, and tremor characteristics were collected to test associations with functional connectivity. For normative context, data from the 1000 Functional Connectomes Project were analyzed using an identical approach. We observed that tremor and demographic variables were correlated with functional connectivity of central oscillatory network components. Furthermore, relative to healthy comparison participants, patients with orthostatic tremor exhibited qualitatively different patterns of cerebellar resting state functional connectivity. Our study enhances the current understanding of brain network differences related to orthostatic tremor and is consistent with a hypothesized selective decoupling of cerebellum. Additionally, associations observed between functional connectivity and factors including medical history and tremor features may suggest targets for treatment of orthostatic tremor.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor

Phipps,

Whitney,

Shou

et al. 2024

Brain Sciences

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“…Recent years have seen an exponential increase in the number of scientific publications on OT, mainly distributed through the fields of epidemiology, pathophysiology, clinical phenomenology, diagnostic tools, and treatment options. 8,22–52…”

Section: Introductionmentioning

confidence: 99%

The Top 50 Most-Cited Articles in Orthostatic Tremor: A Bibliometric Review

Ruiz¹,

Benito‐León²

2019

Tremor and Other Hyperkinetic Movements

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Bibliometrics is a statistical analysis of books, articles, and/or other publications. Bibliometric analysis use data on numbers and authors of scientific publications and on articles and the citations therein, and in patents, to evaluate the output of individuals/research teams, institutions, and/or countries; to identify national and international networks; and to delineate the development of novel multidisciplinary areas of science and technology. 1

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“…The underlying pathogenesis of POT is incompletely understood but dysfunction of the cerebello-thalamo-cortical motor pathway is thought to play a key role ( 2 – 6 ). POT is a progressive disorder and its pharmacological and surgical treatments are often disappointing, resulting in a gradual and slow worsening of a patient’s condition over the course of the disease ( 7 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life Is Severely Affected in Primary Orthostatic Tremor

et al. 2018

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BackgroundPrimary orthostatic tremor (POT) is a movement disorder characterized by unsteadiness upon standing still due to a tremor affecting the legs. It is a gradually progressive condition with limited treatment options. Impairments in health-related quality of life (HQoL) seem to far exceed the physical disability associated with the condition.MethodsA multi-center, mixed-methodology study was undertaken to investigate 40 consecutive patients presenting with POT to four movement disorder centers in France. HQoL was investigated using eight quantitative scales and a qualitative study which employed semi-structured interviews. Qualitative data were analyzed with a combination of grounded-theory approach.ResultsOur results confirm that HQoL in POT is severely affected. Fear of falling was identified as the main predictor of HQoL. The qualitative arm of our study explored our initial results in greater depth and uncovered themes not identified by the quantitative approach.ConclusionOur results illustrate the huge potential of mixed methodology in identifying issues influencing HQoL in POT. Our work paves the way for enhanced patient care and improved HQoL in POT and is paradigmatic of this modern approach for investigating HQoL issues in chronic neurological disorders.

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Primary orthostatic tremor: is deep brain stimulation better than spinal cord stimulation?

Cited by 10 publications

References 5 publications

Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor

Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor

The Top 50 Most-Cited Articles in Orthostatic Tremor: A Bibliometric Review

Health-Related Quality of Life Is Severely Affected in Primary Orthostatic Tremor

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