Primary Orbital Melanomas

Tellado, Miguel; Specht, Charles S.; McLean, Ian W.; Grossniklaus, Hans E.; Zimmerman, Lorenz E.

doi:10.1016/s0161-6420(96)30585-x

Cited by 44 publications

(54 citation statements)

References 12 publications

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“…Series of primary orbital melanomas show ages varying between 12 and 84 years 3,5 . There are only two cases of African-descendant patients [3][4][5] .…”

Section: Discussionmentioning

confidence: 99%

“…Orbital primary melanomas are probably originated from the congenital remains of cells from the neural crest, and may be found along ciliary nerve, scleral emissary veins or the leptomeninx of the optical nerve [3][4][5][6] . Due to the small number of cases, there is not much data regarding its clinical behavior, however, the most common clinical presentation is pain-associated proptosis originated from a diffuse orbital mass4.…”

Section: Discussionmentioning

confidence: 99%

“…These are rare lesions, representing about 0.09% of the extracutaneous malignant neoplasias1. In the orbit, it is frequently secondary to invasions by conjunctiva, choroid melanomas or from adjacent regions, or blood-born metastases 3 . The primary orbital melanoma represents less than 1% of the primary orbital neoplasias 4 .…”

Section: Introductionmentioning

confidence: 99%

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Melanoma maligno primário da órbita

Patrocı́nio

Lourenço

Silva

et al. 2006

Rev. Bras. Otorrinolaringol.

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“…Series of primary orbital melanomas show ages varying between 12 and 84 years 3,5 . There are only two cases of African-descendant patients [3][4][5] .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Melanoma maligno primário da órbita

Patrocı́nio

Lourenço

Silva

et al. 2006

Rev. Bras. Otorrinolaringol.

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“…1 Histologically these tumours resemble uveal melanomas 2 and, in the largest series reported, 90% were associated with blue naevus and 48% had pre-existing melanosis. 3 Jacobiec 4 proposed that persistence of 'atavistic dermal melanocytes' from the embryological neural crest migration give rise to melanomas in the orbit, an area which is normally free from melanocytes. 'Melanoma of soft parts' (MMSP) is also known as clear cell sarcoma, due to its usual association with tenosynovial structures and the typical histological appearance of variable-sized nests of uniform plump spindle cells-with clear cytoplasm separated by fibrous septa.…”

Section: Discussionmentioning

confidence: 99%

Primary orbital melanoma masquerading as vascular anomalies

Lee

Sandy

Rose

et al. 2002

Eye

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Purpose To review two cases of primary orbital melanoma presenting like orbital vascular anomalies. Methods Retrospective review of clinical presentation, treatment, radiology and pathology for two patients under the care of the Orbital Clinic at Moorfields Eye Hospital. Results Both lesions presented with the appearance and behaviour of vascular anomalies. In one case, a spindle cell melanoma appeared to be a low flow vascular anomaly with a loculated secondary haemorrhage and, in the other case, a melanoma of soft parts was considered to be an arteriovenous malformation and responded partially to embolisation. Conclusion Primary malignant melanoma may present as a secondary vascular lesion of the orbit and this very rare tumour should be considered in the differential diagnosis of any vascular anomaly.

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“…1,2 The vast majority of orbital melanomas are either metastatic or represent extension from skin and conjunctival melanomas. 3 Distinguishing primary orbital melanoma from metastatic orbital melanoma or extension from adjacent structures is essential because the treatment for primary melanoma of the orbit is usually orbital exenteration, whereas exenteration would only be appropriate as a palliative measure in cases of metastasis or extension from adjacent orbital structures.…”

Section: Introductionmentioning

confidence: 99%

Primary orbital melanoma in association with cellular blue nevus

El-Sawy¹,

Bakhoum²,

Tetzlaff³

et al. 2014

Digit J Ophthalmol

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Purpose-To describe 3 cases of primary orbital melanoma associated with either known or subsequently discovered cellular blue nevus. Methods-The clinical records and surgical specimens of 3 patients who underwent orbital exenteration for primary orbital melanoma and who had a cellular blue nevus diagnosed before or after detection of the melanoma were retrospectively reviewed.Results-All 3 patients presented with signs and symptoms of an orbital mass. Subsequent biopsy revealed invasive melanoma. One patient had a known history of congenital cellular blue nevus of the eyelid from which the orbital melanoma originated. The other 2 patients had no known history of cutaneous pigmentation or blue nevus. In these 2 patients, the cellular blue nevus was detected on pathologic review of the orbital exenteration specimen (1 patient) or surgical biopsy specimen (1 patient). All 3 patients underwent total body positron emission tomography/computed tomography, and in all 3 results were negative for other sites of disease involvement. In the 2 patients without a previously known nevus a total body skin check was negative for other primary melanoma lesions. All 3 patients underwent orbital exenteration followed by postoperative radiation therapy.Conclusions-Thorough evaluation of biopsy specimens of "primary" orbital melanoma is warranted to ensure identification of any associated blue nevus because blue nevi are precursor lesions for orbital melanoma, and the presence of a blue nevus would support a primary orbital melanoma rather than a metastatic lesion. Patients with a known blue nevus of the periocular skin and ocular adnexa should be monitored closely for signs of malignant transformation.

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Primary Orbital Melanomas

Cited by 44 publications

References 12 publications

Melanoma maligno primário da órbita

Melanoma maligno primário da órbita

Primary orbital melanoma masquerading as vascular anomalies

Primary orbital melanoma in association with cellular blue nevus

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