Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan

Chen, Y.K; Huang, Hsiao‐Ling; Lm, Lin; Lin, Ching-Yi

doi:10.1016/s1368-8375(98)00101-8

Cited by 230 publications

(202 citation statements)

References 29 publications

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“…No randomised controlled trials have yet been performed to compare the effectiveness of surgery with chemoradiation, and the usefulness of chemoradiation therapy involving systemic chemotherapy thus remains to be clarified. After surgery, the 5-year survival rate ranged from 27 to 60% of stage III patients, while it ranged from approximately 12 to 40% of stage IV patients (Chen et al, 1999;Sessions et al, 2002;Greenberg et al, 2003;Lo et al, 2003;Gorsky et al, 2004;Liao et al, 2006;Fan et al, 2007); our results were therefore similar to the results after surgery. In particular, the results of arterial injection therapy by cisplatin with sodium thiosulphate were excellent.…”

Section: Discussionsupporting

confidence: 81%

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

et al. 2008

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The objective of this study was to investigate the therapeutic results of arterial injection therapy via the superficial temporal artery for 134 cases of stages III and IV (M0) oral cavity cancer retrospectively, and to clarify the prognostic factors. We administered intraarterial chemoradiotherapy by continuous infusion of carboplatin in 65 cases from January 1993 to July 2002. Systemic chemotherapy was performed on 26 cases at the same time. We administered intra-arterial chemoradiotherapy by cisplatin with sodium thiosulphate in 69 cases from October 2002 to December 2006. Systemic chemotherapy was performed on 48 cases at the same time. The 3-year local control rate was 68.6% (T2-3: 77.9%; T4: 51.3%), and the 3-year survival rate was 53.9% (stage III: 62.9%; stage IV: 45.3%). Regarding the results of multivariate analysis of survival rates, age (o65), selective intra-arterial infusion, and the use of cisplatin as an agent for intra-arterial infusion were significant factors. The therapeutic results of intra-arterial chemoradiotherapy via the superficial temporal artery were not inferior to the results of surgery. In particular, the results of arterial injection therapy by cisplatin with sodium thiosulphate were excellent, so we believe that it will be a new therapy for advanced oral cavity cancer.

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Section: Discussionsupporting

confidence: 81%

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

et al. 2008

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“…Cancers of buccal mucosa, tongue, and gingiva constitute the majority of oral cancer in the Asian population, and that is related to the exposure to the carcinogen in these anatomical areas (2). It is estimated that approximately 90-95% of oral cancers are squamous cell carcinoma (OSCC) (3), and oral cancer has been shown to progress from hyperplasia, to mild-to-moderate dysplasia, severe dysplasia, and carcinoma in situ (4). Surgery is the standard treatment for OSCC, but the differences in primary sites and the complex anatomy of the head and neck give rise to intricate patterns of local invasion and regional spread.…”

mentioning

confidence: 99%

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

Chen

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

106

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The incidence and mortality rate of oral cancer continue to rise, partly due to the lack of effective early diagnosis and increasing environmental exposure to cancer-causing agents. To identify new markers for oral cancer, we used a sialylation probe to investigate the glycoproteins differentially expressed on oral cancer cells. Of the glycoproteins identified, B7 Homolog 3 (B7-H3) was significantly overexpressed in oral squamous cell carcinoma (OSCC), and its overexpression correlated with larger tumor size, advanced clinical stage, and low survival rate in OSCC patients. In addition, knockdown of B7-H3 suppressed tumor cell proliferation, and restoration of B7-H3 expression enhanced tumor growth. It was also found that the N-glycans of B7-H3 from Ca9-22 oral cancer cells contain the terminal α-galactose and are more diverse with higher fucosylation and better interaction with DC-SIGN [DC-specific intercellular adhesion molecule-3 (ICAM-3)-grabbing nonintegrin] and Langerin on immune cells than that from normal cells, suggesting that the glycans on B7-H3 may also play an important role in the disease.CD276 | proliferation | glycan sequencing | terminal α-galactose | fucose

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“…Buccal cancers were reported more frequently found in patients with betel nut-chewing habits (Thomas and MacLennan, 1992). However, tongue was only associated with cancers of smokers and the most common site among patients without any oral habits (Silverman and Griffith, 1972;Chen et al, 1999). In our series, there were very few OSCC patients with betel nut-chewing habit alone but without smoking (seven out of 86 ¼ 8%) and most tumors were located on the tongue (58 out of 86 ¼ 67%).…”

Section: Discussionmentioning

confidence: 49%

“…In our series, there were very few OSCC patients with betel nut-chewing habit alone but without smoking (seven out of 86 ¼ 8%) and most tumors were located on the tongue (58 out of 86 ¼ 67%). Previous data reported that lingual cancers occurred less frequently in patients with betel nut-chewing habit alone (Ko et al, 1995;Chen et al, 1999). Furthermore, Taiwanese betel nuts do not contain tobacco and are different from those in India, where betel nuts nearly always include tobacco, a known cause of oral cancer.…”

Section: Discussionmentioning

confidence: 96%

Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma

et al. 2004

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Recent studies indicated nm23-H1 played a role in cancer progression. Therefore, we investigated clinical significance of nm23-H1 expression in oral squamous cell carcinoma (OSCC). In total, 86 OSCC specimens were immunohistochemically stained with nm23-H1-specific monoclonal antibodies. Immunohistochemical staining of nm23-H1 was confirmed by immunoblotting. The relations between nm23-H1 expression and clinicopathologic variables were evaluated by w 2 analysis. As increased size of primary tumour could escalate metastatic potential and the data of patients at the late T stage might confound statistical analyses, we thus paid special attention to 54 patients at the early T stage of OSCC. Statistical difference of survival was compared by a log-rank test. Immunohistochemically, nm23-H1 expression was detected in 48.8% (42 out of 86) of tumorous specimens. It positively correlated with larger primary tumour size (P ¼ 0.03) and inversely with cigarette-smoking habit (P ¼ 0.042). In patients at the early T stage, decreased nm23 expression was associated with increased incidence of lymph node metastasis (P ¼ 0.004) and indicated poor survival (P ¼ 0.014). Tumour nm23-H1 expression is a prognostic factor for predicting better survival in OSCC patients at the early T stage, which may reflect antimetastatic potential of nm23. Therefore, modulation of nm23-H1 expression in cancer cells can provide a novel possibility of improving therapeutic strategy at this stage. In addition, our results further indicated cigarette smoking could aggravate the extent of nm23-H1 expression and possibly disease progression of OSCC patients.

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Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan

Cited by 230 publications

References 29 publications

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma

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