Primary open angle glaucoma and hypothyroidism

Kitsos,

doi:10.2147/opto.s8048

Cited by 4 publications

(1 citation statement)

References 15 publications

(16 reference statements)

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“…23 George Kitsos in 2010. 24 ) found no association of thyroid dysfunction and OAG. In our study, 16.26% cases had OAG.…”

Section: Resultsmentioning

confidence: 80%

Primary Open Angle Glaucoma in Thyroid Disorder

Garg¹,

Karoli²,

Chawla³

et al. 2016

jebmh

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To assess the association of thyroid profile with open angle glaucoma. DESIGN Cross-sectional observational study. MATERIAL AND METHOD 128 cases of diagnosed thyroid disorder were enrolled. 5 cases dropped out. Ocular examination included applanation tonometry, stereoscopic optic disc photography, and automated perimetry. Correlative association of thyroid disorder and open angle glaucoma was assessed. RESULTS Of 123 patients of thyroid disorder, 87.8% had hypothyroidism and remaining 12.2% had hyperthyroidism. 15.74% of hypothyroidism and 20% of hyperthyroidism patients had open angle glaucoma, which was statistically significant (Pearson chi-square: Value=6.548, df=2, p=0.040). On multivariate analysis with other risk factors like female sex, family history of glaucoma, myopia, hypertension, and diabetes; it was found that hypothyroidism is an independent risk factor for open angle glaucoma. CONCLUSION All patients having thyroid disorder should be investigated for early diagnosis of open angle glaucoma so that if need be antiglaucoma treatment is started at the earliest and the eye maybe saved from any further deterioration.

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“…23 George Kitsos in 2010. 24 ) found no association of thyroid dysfunction and OAG. In our study, 16.26% cases had OAG.…”

Section: Resultsmentioning

confidence: 80%

Primary Open Angle Glaucoma in Thyroid Disorder

Garg¹,

Karoli²,

Chawla³

et al. 2016

jebmh

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The interrelation between hypothyroidism and glaucoma: a critical review and meta‐analyses

Thvilum

Brandt

Brix

2017

Acta Ophthalmologica

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Data on the association between hypothyroidism and glaucoma are conflicting. We sought to shed light on this by conducting a critical review and meta-analyses. The meta-analyses were conducted in adherence with the widely accepted MOOSE guidelines. Using the Medical Subject Heading (MeSH) terms: hypothyroidism, myxoedema and glaucoma or intraocular pressure, case-control studies, cohort studies and cross-sectional studies were identified (PubMed) and reviewed. Using meta-analysis, the relative risk (RR) of coexistence of glaucoma and hypothyroidism was calculated. Based on the literature search, thirteen studies fulfilled the inclusion criteria and could be categorized into two groups based on the exposure. The designs of the studies varied considerably, and there was heterogeneity related to lack of power, weak phenotype classifications and length of follow-up. Eight studies had glaucoma (5757 patients) as exposure and hypothyroidism as outcome. Among these, we found a non-significantly increased risk of hypothyroidism associated with glaucoma (RR 1.65; 95% confidence interval [CI]: 0.97-2.82). Based on five studies (168 006 patients) with hypothyroidism as exposure and glaucoma as outcome, we found the risk of glaucoma to be significantly increased (RR 1.33; 95% CI: 1.13-1.58). Based on these meta-analyses, there seems to be an association between hypothyroidism and glaucoma, which does not seem to be the case between glaucoma and hypothyroidism. However, larger scale studies with better phenotype classification, longer follow-up and taking comorbidity and other biases into consideration are needed to address a potential causal relationship.

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Hypothyroidism and glaucoma: Is there an association?

Bhat

2014

Thyroid Res Pract

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Primary open angle glaucoma and hypothyroidism

Cited by 4 publications

References 15 publications

Primary Open Angle Glaucoma in Thyroid Disorder

Primary Open Angle Glaucoma in Thyroid Disorder

The interrelation between hypothyroidism and glaucoma: a critical review and meta‐analyses

Hypothyroidism and glaucoma: Is there an association?

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