Primary omental Gastrointestinal stromal tumor (GIST)

Todoroki, Takeshi; Sano, Takaaki; Sakurai, Shunsuke; Segawa, Akihisa; Saitoh, Tamotsu; Fujikawa, Koichi; Yamada, Shǔji; Hirahara, Nobutsune; Tsushima, Yoshito; Motojima, Ryuji; Motojima, Teiji

doi:10.1186/1477-7819-5-66

Cited by 33 publications

(32 citation statements)

References 19 publications

(10 reference statements)

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“…No cases of multiple GISTs affecting distant gastrointestinal structures have been reported thus far. Moreover, although still debated, also the peritoneum has been suggested to be a site of origin of primary GIST (7,9). Thus, whether peritoneal nodules may represent multiple GISTs is still unknown.…”

Section: Discussionmentioning

confidence: 99%

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Multiple Primary Sporadic Gastrointestinal Stromal Tumors in the Adult: An Underestimated Entity

Gasparotto

Rossi

Bearzi

et al. 2008

Clinical Cancer Research

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Purpose: Gastrointestinal stromal tumors (GIST) are commonly regarded as solitary tumors.The occurrence of multiple lesions is considered an extraordinary event restricted to pediatric GISTs and rare hereditary conditions. Beyond these well-defined situations, the presentation of multiple synchronous lesions is commonly viewed as the result of the metastatic spreading of a single primary GIST. Based on this axiom, patients with multifocal disease are classified as advanced stage and treated as such.Whether, indeed, the detection of several lesions in sporadic adult GIST patients may be suggestive of phenomena of tumor multiplicity still needs to be clarified. Experimental Design: From a multicentric series of 442 consecutive cases, 26 of which with advanced disease, we selected 5 patients who presented up to three distinct GIST nodules. Five additional cases with similar characteristics were also contributed by two other institutions. The clonal relationship between the synchronous lesions was assessed by comparing KIT/PDGFRA mutation and microsatellite pattern. Results: An independent origin of the synchronous lesions was established in 6 of 10 cases. Notably, in one patient, one lesion arose in the peritoneum, which is ordinarily regarded as a site of metastasis. Conclusions: Our data indicate that a significant fraction of GIST patients with multifocal presentation are actually affected by multiple primary tumors, suggesting that mesenchymal GIST precursor cells of these individuals are somehow primed to transformation. Thus, in the presence of multifocal GIST manifestations, an accurate characterization of the different tumor sites should be undertaken for a proper patient staging and therapy planning.

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Section: Discussionmentioning

confidence: 99%

“…The concordant mutations test recently developed by Begg and coworkers was applied to assess the clonal relationships of the paired lesions based on microsatellite analyses. 9 A clonal origin of synchronous lesions was supported by P V 0.05, whereas P = 1 indicated independent origin (30).…”

Section: Translational Relevancementioning

confidence: 99%

Multiple Primary Sporadic Gastrointestinal Stromal Tumors in the Adult: An Underestimated Entity

Gasparotto

Rossi

Bearzi

et al. 2008

Clinical Cancer Research

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“…They mostly show positive c-kit (CD-117) on immuno-histochemical staining. They typically arise in association with the muscularis propria of the gastrointestinal tract wall [1]. They occur most frequently in the stomach (60 %), jejunum and ileum (30 %), and less frequently in the duodenum (5 %), less than 5 % colorectal, and less than 1 % in the esophagus and appendix [1].…”

Section: Introductionmentioning

confidence: 99%

“…They typically arise in association with the muscularis propria of the gastrointestinal tract wall [1]. They occur most frequently in the stomach (60 %), jejunum and ileum (30 %), and less frequently in the duodenum (5 %), less than 5 % colorectal, and less than 1 % in the esophagus and appendix [1]. The tumors grow mostly submucosally but can manifest as exophytic extra luminal subserosal growth [2].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Stromal Tumor—Single-Center Experience with Review of the Literature

et al. 2013

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GIST or gastrointestinal stromal tumors are the most common mesenchymal tumors of the GI tract showing mostly positive c-kit (CD-117) in immuno-histochemical staining. Most of the times, early diagnosis is missed. Usually, patients present with anemia. Sometimes, the patient can present in emergency with massive GI bleed or intestinal obstruction. The aim of this paper was to make the clinicians aware about the varied presentations of GIST. Presenting herewith is our single-center experience of management of patients of GIST with review of the available literature.

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“…They commonly originate in the stomach, followed by small intestine [1][2][3][4]. They rarely arise in the caecum, with the entire colon and rectum contributing to less than 5 % of all GISTs [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Caecal Gastrointestinal Stromal Tumor with Perforation and Obstruction

Sreevathsa

2012

Indian J Surg Oncol

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Primary omental Gastrointestinal stromal tumor (GIST)

Abstract: Background: We report herein a rare case of primary omental gastrointestinal stromal tumor (GIST).

Cited by 33 publications

References 19 publications

Multiple Primary Sporadic Gastrointestinal Stromal Tumors in the Adult: An Underestimated Entity

Multiple Primary Sporadic Gastrointestinal Stromal Tumors in the Adult: An Underestimated Entity

Gastrointestinal Stromal Tumor—Single-Center Experience with Review of the Literature

Caecal Gastrointestinal Stromal Tumor with Perforation and Obstruction

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