Primary Omental Gastrointestinal Stromal Tumor- What we know based on case series and literature review

Alves, Magda

doi:10.1016/j.ejso.2019.11.355

Cited by 2 publications

(3 citation statements)

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“…The best prognostic features are tumor size and mitotic activity; however, it does not predict the risk for disease progression and malignant potential accurately because of the scarcity of primary omental GIST [7][8][9][10]. There are a few reported cases of GISTs that involved gynecologic tract and presented as pelvic or omental masses, therefore mimicking primary omental or ovarian neoplasm [8,9,[11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Other useful immunohistochemical stains, in this case, were chromogranin and synaptophysin, to rule out neuroendocrine tumors, along with inhibin and calretinin to rule out sex cord stromal tumors. Wherever possible, complete removal of tumor and/or imatinib therapy are the primary alternatives for the patient, although the response is slightly worse than with GIST of the tubular gastrointestinal tract [11][12]14]. New therapies and/or clinical trials are under assessment; more studies are required to further elaborate these cases which primarily occur in the omentum and/or gynecologic tract to better understand the pathophysiology and prognosis of these "metastatic cases with unknown primaries".…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Gastrointestinal Stromal Tumor to the Omentum and Endometrium: A Case Report

2022

IJOR

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Gastrointestinal Stromal Tumor (GIST) is an uncommon stromal malignancy of Gastrointestinal (GI) tract. GISTs have been increasingly reported in sites other than GI tract. Currently, GISTs are considered metastatic when they occur outside GI tract; however, there is a possibility of a primary stromal tumor of omentum and/or gynecologic tract with similar mutation profile and histopathology but different prognosis and clinical behavior. Here, we report a case of 52-year-old female with widespread lesions in her abdomen and pelvis, which turned out to be a GIST; however, no lesions were identified in the GI tract which raises the possibility of omental or ovarian primary stromal tumor. Since GISTs are mutation derived tumors, it is highly likely that the stroma of other locations can undergo similar tumorigenesis due to mutations in c-KIT and/or PDGFRA genes and present similarly to primary GI tract GISTs. More studies are required to look for other possible primary sites and difference in clinical behavior and prognosis to appropriately stage the patient before treatment, as GISTs that occur outside GI tract tends to behave aggressively and are usually resistant to imatinib therapy. Keywords: Gastrointestinal stromal tumor; Omentum; Endometrium; Metastasis; Epithelioid; Carcinomatosis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metastatic Gastrointestinal Stromal Tumor to the Omentum and Endometrium: A Case Report

2022

IJOR

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“…The first symptoms of omental tumors can also be rupture-related bleeding and intestinal obstruction, requiring emergency surgery. The inability to safely remove the tumor due to local invasion is an absolute contraindication for surgical resection[ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Omental mass combined with indirect inguinal hernia leads to a scrotal mass: A case report

Liu

Yao

et al. 2021

WJCC

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BACKGROUND Primary omental tumors are uncommon, and omental fibromas account for 2% of these tumors. Due to the low incidence of omental fibromas and the limited relevant literature, it is challenging for clinicians to make an accurate diagnosis of this condition, especially before surgery. CASE SUMMARY A 30-year-old man was admitted to the hospital because of a left epididymal mass with vague discomfort for more than 1 mo. A physical examination was performed, and the findings showed that the epididymal mass may have entered the abdominal cavity. Pelvic computed tomography was performed in our hospital and revealed a left inguinal hernia with a mass in the hernial contents, and no masses were found in the left epididymis. A traditional inguinal hernia incision was made. Intraoperative hernia contents were found to be of the greater omentum, and a 2.5 cm-diameter mass was found at the distal end of the greater omentum. The scrotum and epididymis did not exhibit other masses. Then, the mass of the greater omentum was excised. Intraoperative frozen pathological examination suggested a spindle cell tumor. The postoperative pathological examination suggested that the mass was an omental angiofibroma. Postoperatively, the patient recovered well and was discharged. Outpatient re-examinations were performed at 1 mo and half a year after the operation and showed no obvious abnormalities. CONCLUSION Due to the low morbidity rate associated with and latent nature of omental tumors, these tumors are difficult to diagnose preoperatively; thorough medical history taking, detailed physical examinations, and necessary imaging auxiliary examinations can help clinicians diagnose and treat these cases.

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Primary Omental Gastrointestinal Stromal Tumor- What we know based on case series and literature review

Cited by 2 publications

References 0 publications

Metastatic Gastrointestinal Stromal Tumor to the Omentum and Endometrium: A Case Report

Metastatic Gastrointestinal Stromal Tumor to the Omentum and Endometrium: A Case Report

Omental mass combined with indirect inguinal hernia leads to a scrotal mass: A case report

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