Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 113 patients.

Abstract

The three immunophenotypes studied are shown to exhibit different clinical patterns. Since the NK/T phenotype carries the worst prognosis, patients who present with NNP-NHL should have their tumors analyzed for CD56 expression.

Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore

“…16 Some studies in the Caucasian population also detected a strong but not invariable association with Epstein-Barr virus. 16,30 In extranasal sites, the association with the virus is more variable, 30 and Tsang et al 31 reported EBER expression in 62.5% of non-nasal CD56-positive TCLs. In this study, 96.7% of the cases of NK/TCL in the upper aerodigestive tract and all the tumors in the extranasal sites were positive for EBER.…”

“…Four cases were lost to followup. The patients were staged clinically according to the Ann Arbor system, 16 except for cases with skin tumors, which were staged according to the TNM staging of cutaneous TCL. 23 Survival was analyzed as a function of time from histologic diagnosis to the last date of follow-up in December 2002, using Kaplan-Meier product limit method.…”

“…A few studies have noted a high incidence of p53 overexpression and/or mutations, 12,13 and some investigators also found an association between p53 mutation with large cell morphology and advanced disease. 14 In this study, we describe the clinicopathologic and genotypic findings of 42 cases of nasal-type NK/ TCL in Singapore, which is a multiracial society populated predominantly by Asians, and compared our findings with those of other series reported in the Eastern 8,[15][16][17][18] and Western populations. [19][20][21][22] We analyzed the clonality of T-cell receptor-g gene using both traditional agarose gel electrophoresis and highly sensitive capillary electrophoresis in order to determine the proportion of NK/TCL that are of true NK derivation and compared these tumors with their T-cell counterparts with regards to their histologic features and clinical behavior.…”

Nasal natural killer/T‐cell lymphoma

“…Evidence of EBV has also been found in NK/T cell lymphoma [7]. They are rare and are mainly seen in Asia and Latin America.…”

Clinicopathologic Conference: Case 2

“…These lymphomas have also been described in immunosuppressed and post-transplant patients [1]. They show a predominantly extranodal presentation, with the sites of predilection being the nasal cavity, and paranasal sinuses with extension into the nasopharynx, orbit, oral cavity, palate, and oropharynx [1,4]. Nasal lymphomas present as localized disease with symptoms such as nasal obstruction, discharge, or epistaxis due to the presence of a mass lesion, or with extensive midfacial destructive lesions (so-called lethal midline granuloma) [1,5].…”