Primary non-Hodgkin’s lymphoma of the vagina (PNHLV): a gynaecologist’s enigma!

Bhagat, Nanak; Kalkur, Pallavi; Kalkur, Sanjaya

doi:10.1136/bcr-2018-228544

Cited by 3 publications

(7 citation statements)

References 9 publications

(14 reference statements)

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“…More than 80% of those are squamous cell carcinoma, but other histologic types such as adenocarcinomas, malignant melanomas, and sarcomas also occur [17] . There are also reported cases for neuroendocrine carcinomas, lymphoma and extragastrointestinal stromal tumors though these are extremely rare [17][18][19][20] . The radiological appearance of those malignant lesions are likely to be ill-defined and irregular with an infiltrative or a lobulated mass.…”

Section: Discussionmentioning

confidence: 99%

Superficial myofibroblastoma of the vagina with a stalk: case report of a rare vaginal tumor with notable radiological findings

Tomita

Eriko

Yuzawa

et al. 2021

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Superficial myofibroblastoma of the vagina with a stalk: case report of a rare vaginal tumor with notable radiological findings

Tomita

Eriko

Yuzawa

et al. 2021

Radiology Case Reports

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“…The true origin of PLFGT remains unclear. Bhagat et al [ 10 ] and Au et al [ 11 ] found that the most common sites of PLFGT were cervix and ovary, while vagina and uterus were scarce. Stabile et al [ 8 ] and Slonimsky et al [ 7 ] reported that ovary was the most common site of PLFGT, followed by cervix.…”

Section: Discussionmentioning

confidence: 99%

“…In line with previous research, the ovary remains the most prevalent site of PLFGT. As mentioned in previous studies [ 7 , 8 , 10 , 11 ], diffuse large B cell lymphoma (DLBCL) is the most common histological type. These findings were also consistent with our study, most tumors were of DLBCL histology (12/13, 92.3%), while follicular subtype lymphoma was relatively rare observed (1/13, 7.7%).…”

Section: Discussionmentioning

confidence: 99%

“…Uterus corpus, vagina, and vulva are less common primary positions [ 8 ]. Patients with PLFGT in early stages are often asymptomatic, and common symptoms of more advanced stages are vaginal bleeding or discharge, abdominal pain, distension, and pelvic mass [ 9 , 10 ]. In clinical practice, patients with PLFGT initially present to their gynecologists.…”

Section: Introductionmentioning

confidence: 99%

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Primary lymphoma of the female genital tract masquerading as gynecological malignancy

Shi,

Li,

et al. 2024

BMC Women's Health

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Background Primary lymphoma of the female genital tract (PLFGT) is a rare malignant tumor in the female reproductive system, with a low incidence and few clinical reports. The aim of this study is to report our institutional experience with this rare malignancy and emphasize the need for increasing the awareness about PLFGT presenting with gynecologic symptoms. Methods The medical records of patients diagnosed with PLFGT from March 2014 to November 2022 in the First Affiliated Hospital of Wannan Medical College were reviewed. Histological classification and staging were based on the World Health Organization and Ann Arbor systems, respectively. Results There were 13 patients with diagnosis of PLFGT and the median length of follow-up was 31 months (0-102 months). The main clinical symptoms included postmenopausal vaginal bleeding, pelvic mass and abdominal pain. Serum LDH increased in 10 patients and serum CA125 elevated in 2 patients. The tumor of ovarian or uterine presented as solid masses in CT or MRI, and ascites was rare. The histological subtypes were diffuse large B-cell (n = 12) and follicular (n = 1) lymphoma. Tumors were located in ovary (n = 8), uterus (n = 3), and cervix (n = 2). According to the Ann Arbor staging system, 6 cases were classified as stage II and 7 cases were classified as stage IV, respectively. A total of 10 patients underwent surgery. Combination chemotherapy was used in 10 patients. Eight patients had tumor-free survival, 1 patient had recurrent disease, 3 patients died and 1 patient lost to follow-up. The median survival time was 32 months (1-102 months). Conclusion PLFGT usually presents as gynecological symptoms and solid masses in pelvis. Surgery or biopsy was the way to obtain the pathologic diagnosis, and combination chemotherapy is the efficient method for PLFGT. Making an accurate preoperative diagnosis is of paramount importance to avoid radical gynecologic surgery.

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“…Squamous cell carcinoma is the most common histological type, while primary lymphoma of the vagina is rare 7. DLBCL is the most common vaginal lymphoma while Burkitt’s lymphoma was even more rare 3 8–11. The reported age at presentation varies widely between 15 and 79 years.…”

Section: Discussionmentioning

confidence: 99%

Diffuse large B-cell lymphoma of the vagina in pregnancy

et al. 2020

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A 28-year-old primigravida was evaluated for complaints of difficulty urinating and pelvic pain of 6-weeks duration. She denied fever, night sweats, weight loss or fatigue. Pelvic ultrasonography revealed a single fetal pole with cardiac activity and a 7 cm mass in the anterior vagina which encased the urethra. The diagnosis of diffuse large B-cell lymphoma germinal centre type was made on analysis of biopsied pelvic mass. Whole body MRI revealed the disease was limited to the vagina. The patient received six cycles of Rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone with significant improvement in her symptoms. Serial ultrasounds over the subsequent months showed appropriate development of the fetus. Whole body MRI after treatment showed decreased size and decreased signal of the primary pelvic mass compatible with favourable treatment response. Challenges in the management of this rare presentation of lymphoma are discussed.

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Primary non-Hodgkin’s lymphoma of the vagina (PNHLV): a gynaecologist’s enigma!

Cited by 3 publications

References 9 publications

Superficial myofibroblastoma of the vagina with a stalk: case report of a rare vaginal tumor with notable radiological findings

Superficial myofibroblastoma of the vagina with a stalk: case report of a rare vaginal tumor with notable radiological findings

Primary lymphoma of the female genital tract masquerading as gynecological malignancy

Diffuse large B-cell lymphoma of the vagina in pregnancy

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