Primary non-Hodgkin's lymphoma of the liver in a patient with hepatitis B, C and HIV infections

Bauduer, Frédéric; Marty, Fabrice; Gemain, M.-C.; Dulubac, Elisabeth; Bordahandy, R

doi:10.1002/(sici)1096-8652(199703)54:3<265::aid-ajh17>3.0.co;2-c

Cited by 20 publications

(18 citation statements)

References 3 publications

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“…Elevated LDH, with normal alpha-fetoprotein (AFP) and CEA, remains a valuable biologic feature [5]; but in our case, all these three markers were negative. Hypercalcemia is found in 40 % of the patients for an unknown reason.…”

Section: Discussionmentioning

confidence: 56%

“…Hepatitis C is found in 40-60 % of patients with PHL. The possible roles of HCV, cirrhosis, and therapeutic interferon in lymphomagenesis remain hypothetical; however, our patient was not positive for HCV [1,3,5,7]. Conflicting theories exist on the association of HBV infection and PHL [4,8,17,18].…”

Section: Discussionmentioning

confidence: 83%

“…Similarly, the disease may be of either T-or B-cell origin [10]. Most PHL corresponds to a larger cell type and demonstrates a B-cell immunophenotype [5]. The predominant histological type of PHL is diffuse large B-cell lymphoma [6,8].…”

Section: Discussionmentioning

confidence: 99%

“…Although the liver contains lymphoid tissue, host factors may make the liver a poor environment for the development of malignant lymphoma [4]. Even though there have been reports regarding this disease entity, wherein most patients were treated with chemotherapy, with some physicians employing a multimodality approach including surgical resection, the optimal therapy is still unclear and the outcomes are uncertain [2,[5][6][7]. We present a case of hepatic marginal zone B-cell lymphoma treated with surgical resection and adjuvant chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Primary Hepatic Marginal Zone B Cell Lymphoma : A Case Report and Review of the Literature

Kim

Byun

et al. 2012

Indian J Surg

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Background Primary hepatic lymphoma (PHL) is a very rare malignancy, and constitutes about 0.016 % of all cases of non-Hodgkin's lymphoma and is often misdiagnosed. The optimal therapy is still unclear and the outcomes are uncertain. Among PHLs, a primary hepatic low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is extremely rare. Methods We present a case of primary hepatic lymphoma (MALT lymphoma) treated with surgical resection and adjuvant chemotherapy. A 38-year-old Korean man, who was diagnosed with chronic hepatitis B 20 years ago, was admitted for liver biopsy after liver lesions were detected on follow-up computed tomography scan (CT). Liver biopsy revealed the diagnosis of marginal zone B-cell malignant lymphoma (MALT lymphoma). The preoperative clinical staging was IE, given that no additional foci of lymphoma were found anywhere else in the body. The patient underwent left hemihepatectomy. Subsequently, the patient received two cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) regimen.Results After 15 months of follow-up, the patient is alive and well without any evidence of disease recurrence. Conclusion Although the prognosis is variable, good response to early surgery combined with postoperative chemotherapy can be achieved in strictly selected patients.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary Hepatic Marginal Zone B Cell Lymphoma : A Case Report and Review of the Literature

Kim

Byun

et al. 2012

Indian J Surg

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“…Majority of NHL lymphomas have B-cell immunophenotype of large cell type, as was found in our case too. 11 The presentation of primary NHL of the liver is right quadrant pain, fatigue, anorexia, weight loss and nausea. Our patient was mainly symptomatic from her hepatomegaly and anemia.…”

mentioning

confidence: 99%

Primary Liver Sinusoidal Non-Hodgkin's Lymphoma Presenting as Acute Liver Failure

Nagral

Jhaveri

Kalthoonical

et al. 2015

Journal of Clinical and Experimental Hepatology

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We describe a case of a middle-aged woman, who presented to us with fever, anorexia, abdominal distension from a massive hepatomegaly, low hemoglobin, and acute liver failure. A liver biopsy revealed B cell non-Hodgkin's lymphoma predominantly in the sinusoids with CD10, CD20, and Bcl-2 positive on immunohistochemistry. She initially responded well to chemotherapy but succumbed 6 months later to the recurrence of disease. Sinusoidal non-Hodgkin's lymphoma of the liver should be considered in the differential diagnosis of a patient with large hepatomegaly presenting with acute liver failure. ( J CLIN EXP HEPATOL 2015;5:341-343) M alignancies of the liver are known to rarely cause acute liver failure. 1,2 We describe a rare primary malignancy of the liver presenting with acute liver failure.A 53-year-old housewife presented with history of fever, anorexia, and abdominal distension of 2 weeks duration. She was well prior to the onset of these symptoms. She gave history of being treated for carcinoma breast (infiltrating ductal carcinoma of the breast) five years back with surgery (modified radical mastectomy) and chemotherapy (Paclitaxel-based regimen with Tamoxifen). She denied any chest pain, abdominal pain, vomiting, and diarrhea, blood in stools, night sweats and weight loss. Clinically she had pallor and massive firm hepatomegaly, palpable up to the right iliac fossa. There was no evidence of lymphadenopathy or stigmata of chronic liver disease.Her complete blood count showed hemoglobin of 5.6 g %, WBC count of 4970/cmm and platelet count of 1,70,000/mm. Her liver profile showed bilirubin of 2.5 mg/dl, ALT and AST of 165 and 186 U/L respectively, alkaline phosphatase of 217 U/L (normal range 30-150), serum albumin of 3.8 g/dl, INR of 1.7 with normal creatinine and serum electrolytes. Her HBsAg, anti-HCV, anti-EBV IgM and HIV serology were negative. Serum AFP was normal. Contrast enhanced computed tomography (CT) showed massive hepatomegaly with no focal lesions, splenomegaly with minimal bilateral pleural effusion and minimal fluid in the pelvis.On the second day of admission, she developed altered sensorium and drowsiness with high arterial ammonia of 140 mmol/L (normal range 9-33).A percutaneous liver biopsy was performed under cover of fresh frozen plasma. Her liver biopsy revealed hepatic sinusoidal B cell non-Hodgkin's lymphoma, which on immunochemistry showed CD10 and CD20 positivity (implying lymphocyte germinal center origin) and Bcl 2 positivity (implying B cell origin) (Figures 1-3). The cyto keratin (CK) marker on immunohistochemistry was negative thereby ruling out metastases from the previous breast cancer. Bone marrow aspiration did not show any involvement by the lymphoma.She received cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP) regimen with supportive care including anti-coma measures, hydration and blood products. Within 48 h of initiation of treatment, she showed improvement in sensorium and regression of liver span by 5 cm. She had a drop in her leukocyte count after...

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Primary Lymphoma of Liver—a Rare Space-Occupying Lesion

Patkar

Dutt

Shah

et al. 2020

J Gastrointest Canc

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Primary non-Hodgkin's lymphoma of the liver in a patient with hepatitis B, C and HIV infections

Cited by 20 publications

References 3 publications

Primary Hepatic Marginal Zone B Cell Lymphoma : A Case Report and Review of the Literature

Primary Hepatic Marginal Zone B Cell Lymphoma : A Case Report and Review of the Literature

Primary Liver Sinusoidal Non-Hodgkin's Lymphoma Presenting as Acute Liver Failure

Primary Lymphoma of Liver—a Rare Space-Occupying Lesion

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