Primary non-Hodgkin's lymphoma of the skull with extra and intracranial extension presenting with bulky scalp mass lesion

Jaiswal, Manish; Gandhi, Ashok; Purohit, Devendra; Singhvi, Shashi; Mittal, Radhey Shyam

doi:10.4103/1793-5482.145093

Cited by 5 publications

(10 citation statements)

References 12 publications

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“…When the mass gradually invades the cranial skull, dura mater, or infiltrates the cortex, corresponding focal neurologic signs appear such as headache, limb numbness, hemiplegia, and convulsions. [3,6,16,17] In our case, the patient had a history of head trauma and his scalp mass gradually increased to a large size. According to the literature, the differential diagnoses of PCVL include meningioma, metastatic infiltration, histiocytosis, subdural hematoma, plasma cell tumors, and osteomyelitis.…”

Section: Discussionmentioning

confidence: 87%

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Head trauma complicated with primary cranial vault lymphoma

Huang

Tang

et al. 2019

Medicine

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Rationale: Primary cranial vault lymphoma (PCVL) is an extremely rare extranodal lymphoma in the skull. This case study investigates the clinical features, so as to improve the understanding of the diagnosis and therapy. Patient concerns: A 31-year-old male presented painful scalp mass at the site of 1-month-old head trauma. Diagnosis: The final diagnosis was plasma cell lymphoma, which is a rare subtype of diffuse large B-cell lymphoma based on biopsy and immunohistochemistry findings. Interventions: The patient received total tumor resection in combination with chemotherapy Outcomes: The patient survived without signs of systemic dissemination for 12 months after surgery at the time of last follow-up. Lessons: Trauma may be one of the factors that induce PCVL. The final diagnosis of PCVL depends on pathology and immunohistochemistry findings. A combined treatment of surgery, chemotherapy, and radiotherapy can achieve favorable outcomes.

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Section: Discussionmentioning

confidence: 87%

“…Head MRI can more accurately define the boundaries of PCVL lesions, and detect the invasion of the meninges and brain parenchyma, providing valuable information for targeted treatment strategies. [17] A whole-body CT scan or PET-CT helps to exclude the involvement of other parts of the body.…”

Section: Discussionmentioning

confidence: 99%

Head trauma complicated with primary cranial vault lymphoma

Huang

Tang

et al. 2019

Medicine

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“…It's occurrence in the skull is actually the rarest to find and is seen in only 1% of primary bone lymphoma, while the femur (50%) and pelvis (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)% are the two most common sites, and others include the tibia/ fibula, humerus, spine and scapula [1,2]. Our patient was diagnosed at the age of 26, much younger than the median age of this population which was 48 years in 19 similar cases of primary bone lymphoma of the skull which we reviewed [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…Our patient was diagnosed at the age of 26, much younger than the median age of this population which was 48 years in 19 similar cases of primary bone lymphoma of the skull which we reviewed [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

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Primary Bone Burkitt’s like Lymphoma of the Skull Mimicking Meningioma - Case Report and Review of Literature

Nader¹,

Saad²,

Najjar³

et al. 2017

J Leuk

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Primary Bone Lymphoma of the skull is extremely rare and has a variable clinical course and prognosis. We are describing a case of a 26 year old woman who presented with a 2 year history of intermittent scalp swelling and skull pain. Brain MRI showed thickening of the bilateral frontal bones and band thickening of the underlying meninges suggestive of band meningiomatosis. Patient was presumably diagnosed with a meningioma based on radiological findings and underwent resection; however, pathology was consistent with a B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. A PET CT scan showed sacral bone hypermetabolic lesion which was biopsied and consistent with same lymphoma features. She received chemotherapy with Rituximab and Hyper-CVAD protocol (Table 1) and had a sustained ongoing complete remission 19 months after her initial diagnosis. Several cases of primary lymphoma of the skull or cranial vault have been described in the literature, but only one other case with the same pathology of Burkitt-like lymphoma was found.

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Successful CNS-Centric Therapeutic Management and Genomic Profiling of Primary Cranial Vault Diffuse Large B-Cell Lymphoma

Davis

Kimbrough

Moustafa

et al. 2023

JBM

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Primary cranial vault lymphoma (PCVL) is a rare lymphoma involving the skull with or without extra- and intracranial extension. Most cases of PCVL are diffuse large B-cell lymphoma (DLBCL). We report a case of primary cranial vault diffuse large B-cell lymphoma (PCV-DLBCL) that was successfully treated with anthracycline-based chemoimmunotherapy (CIT) alternating with central nervous system (CNS)-directed CIT with high-dose methotrexate and high-dose cytarabine. CNS-centric therapy was given for suspected cerebral cortical involvement and presumed elevated risk of CNS recurrence. The patient has remained in complete remission for 4.25 years following treatment. We suggest that PCV-DLBCL is potentially curable with CNS-directed therapy. Additionally, we provide genomic profiling results indicating an indeterminate cell of origin and multiple genetic mutations which are not frequently seen in DLBCL.

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Primary non-Hodgkin's lymphoma of the skull with extra and intracranial extension presenting with bulky scalp mass lesion

Cited by 5 publications

References 12 publications

Head trauma complicated with primary cranial vault lymphoma

Head trauma complicated with primary cranial vault lymphoma

Primary Bone Burkitt’s like Lymphoma of the Skull Mimicking Meningioma - Case Report and Review of Literature

Successful CNS-Centric Therapeutic Management and Genomic Profiling of Primary Cranial Vault Diffuse Large B-Cell Lymphoma

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