Primary Non-Hodgkin’s Lymphoma of Penis Masquerading as a Non-Healing Ulcer in the Penile Shaft

Abstract

Primary malignant lymphoma of the male external genitalia is extremely rare and it is even rarer in the penis. Because of its rarity, the possibility of delay in diagnosis and mismanagement is always there. It can present as a nodule, non-healing ulcer, stricture urethra or periurethral abscess. We report a case presenting first a nodule and later on as a non-healing ulcer which was diagnosed by corporal biopsy and managed successfully with chemotherapy.

Presentation of Diffuse Large B-Cell Lymphoma Relapse as a Penile Mass

“…Presentation with a primary penile mass is extremely rare for lymphomas, as reported only in case reports in the literature [2,3,4,5,6,7]. Here we report a case of recurrent lymphoma presenting with a penile mass lesion.…”

Primary Diffuse Large B-Cell Lymphoma of the Penis: A Case and Literature Review

“…Most patients manifested mass, diffuse swelling, non-healing ulcer in the penis, difficulty with urination, etc. [5][6][7][8][9][10][11][12][13][14] Remarkably, painless mass was observed as the first symptom in 36.8% of cases, which could be explained as a reason for the delay in diagnosis. Additional studies are needed on molecular mechanisms and specific indicators, which should give clinicians comprehensive awareness and understanding of the early-stage symptoms of this disease and avoid misdiagnosis.…”

“…Primary extranodal DLBCL commonly presents in the stomach, mediastinum, central nervous system, and testicle, among which the penis remains rare. 4 Most of the reported primary lymph malignant of the penis sited in the penile shaft and/or the glans penis without specific symptoms, 5 exhibiting penile masses, nodules, diffuse swelling, refractory erosions and ulcers, [5][6][7][8][9][10][11][12][13][14] and dysuria occurs when lymphoma masses compress the urethra. [15][16][17][18] There are also cases of penile erectile dysfunction, penis swelling and other clinical manifestations.…”

A report of two deep-seated noncutaneous penile tumors: more than meets the eye

“…Most cases of penile lymphoma represent direct extension of pelvic disease or hematogenous or lymphatic spread of disease from elsewhere [11] . The presentation of penile lymphoma varies, presenting as a palpable mass, skin ulcer, or diffuse swelling [11] , [12] , [13] , [14] ; additional symptoms such as dysuria or pyuria may be present, with phimosis or priapism less often seen [12] , [13] . Most cases are located on the penile shaft or on the glans penis [11] , [12] , [13] .…”