Primary neuroendocrine tumors of the liver: MRI features in two cases

Hoef, M. van der; Crook, David; Marinček, Borut; Weishaupt, Dominik

doi:10.1007/s00261-003-0064-4

Cited by 20 publications

(17 citation statements)

References 13 publications

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“…8,9 In this study, preoperative liver biopsy was performed in seven of eight patients, and NET was correctly diagnosed in four. This preoperative pathologic diagnosis of hepatic NET can lead to performing further study on the possibility of metastasis from other sites.…”

Section: Discussionmentioning

confidence: 74%

Surgical Treatment of Primary Neuroendocrine Tumors of the Liver

Hwang

Lee

et al. 2008

Journal of Gastrointestinal Surgery

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Primary neuroendocrine tumor (NET) of the liver is a very rare neoplasm, requiring strict exclusion of possible extrahepatic primary sites for its diagnosis. We have analyzed our clinical experience of eight patients with hepatic primary NET. From January 1997 to December 2006, eight patients with a mean age of 50.4 +/- 9.5 years underwent liver resection for primary hepatic NET. Seven patients underwent preoperative liver biopsies, which correctly diagnosed NET in four. Of the eight patients, six underwent R0 and two underwent R1 resection. Diagnosis of hepatic primary NET was confirmed immunohistochemically and by the absence of extrahepatic primary sites. All tumors were single lesions, of mean size 8.6 +/- 5.7 cm, and all showed positive staining for synaptophysin and chromogranin. During a mean follow-up of 34.0 +/- 39.7 months, three patients died of multiple liver metastases after tumor recurrence, whereas the other five remain alive to date, making the 5-year recurrence rate 40% and the 5-year survival rate 56.3%. Univariate analysis showed that Ki67 proliferative index was a risk factor for tumor recurrence. In conclusion, although primary hepatic NET is very rare, it should be distinguished from other liver neoplasms. The mainstay of treatment is curative liver resection.

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Section: Discussionmentioning

confidence: 74%

Surgical Treatment of Primary Neuroendocrine Tumors of the Liver

Hwang

Lee

et al. 2008

Journal of Gastrointestinal Surgery

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“…Gross radiographic features can be highly variable with some lesions appearing solid or cystic, as well as having well-circumscribed or diffuse margins. Areas of necrosis have also been described [8]. Because of this highly variable appearance, a PHNET may be initially thought to be a benign lesion such as a hepatic adenoma or hemangioma or be confused with another hepatic malignancy such as HCC or cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Limited CT and MRI characterization of PHNETs has revealed enhancement patterns similar to hepatic NET metastases from the pancreas or gastrointestinal tract [8]. On MRI, both primary tumors and metastases have been reported to appear hypointense on T1 weighted spin-echo sequences and hyperintense on T2 weighted fast spin-echo sequences [8].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Imaging of Primary Hepatic Neuroendocrine Tumors: A Case and Discussion of the Literature

Kellock

Tuong

Harris

et al. 2014

Case Reports in Radiology

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Neuroendocrine tumors (NETs) are derived from neuroendocrine cells that are capable of producing functional peptide hormones. These tumors occur most frequently in the GI tract and lungs. GI NETs frequently metastasize into the liver, though NETs of primary hepatic origin are extremely rare. Ultrasound, CT, and MRI are typically all employed for characterization of these lesions but their appearance on diagnostic imaging can be highly variable. Reported here is an interesting case of a primary hepatic neuroendocrine tumor (PHNET), along with a discussion of the imaging characteristics of these tumors. Additionally, the current standards for definitive diagnosis and treatment of PHNETs are discussed.

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“…On dynamic contrast-enhanced study, early enhancement on arterial phase and washout on portal venous phase are usually seen. On equilibrium phase (5 min after the injection of the contrast), contrast accumulation in the centre may be seen in those with a central scar (Figure 1) [6][7][8].…”

Section: Primary Hepatic Neuroendocrine Tumourmentioning

confidence: 99%

MRI findings of uncommon non-hepatocyte origin primary liver tumours with pathological correlation

Yc¹,

Park²,

Chung³

et al. 2010

BJR

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ABSTRACT. The objective of this article was to illustrate the MRI findings of uncommon non-hepatocyte origin primary liver tumours, correlate them with the pathological features and discuss differential diagnoses. In conclusion, the MRI findings of uncommon benign and malignant non-hepatocyte-origin primary liver tumours vary. Awareness of characteristic MRI features can aid differential diagnosis and prevent unnecessary surgery.

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Primary neuroendocrine tumors of the liver: MRI features in two cases

Cited by 20 publications

References 13 publications

Surgical Treatment of Primary Neuroendocrine Tumors of the Liver

Surgical Treatment of Primary Neuroendocrine Tumors of the Liver

Diagnostic Imaging of Primary Hepatic Neuroendocrine Tumors: A Case and Discussion of the Literature

MRI findings of uncommon non-hepatocyte origin primary liver tumours with pathological correlation

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