Primary neuroendocrine carcinoma of the gallbladder in a dog

Birettoni, Francesco; Porciello, Francesco; Caivano, Domenico; Arcelli, Rolando; Sforna, Monica; Antognoni, Maria Teresa

doi:10.1007/s11259-008-9151-x

Cited by 16 publications

(31 citation statements)

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“…This type of neoplasm in the gallbladder is not related to specific clinical signs. However, anorexia, ascites, weight loss, diarrhea, jaundice, vomiting, abdominalgia and hematemesis was described in animals with carcinoids of the hepatobiliary system (PATNAIK et al, 1981;WILLARD et al, 1988;MORRELL et al, 2002;BIRETTONI et al, 2008;LIPPO et al, 2008). Dogs in the present study had a clinical history of prostration, diarrhea and vomiting, in addition to abdominal pain, but these findings may be related to the splenic tumor lesions, especially in case 2.…”

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confidence: 48%

“…In the present study, the breeds affected were the Shih Tzu and the Cocker Spaniel. Current literature described cases in the Bullmastiff, Beagle, and Rhodesian ridgeback, in addition to two non-breed dogs (WILLARD et al, 1988;MORRELL et al, 2002;BIRETTONI et al, 2008;LIPPO et al, 2008). However, since gallbladder neoplasms are rare in dogs, and a limited number of cases are described in the literature, there is insufficient information to accurately associate predisposition with breed, age, or sex (CULLEN, 2017).…”

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confidence: 99%

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Carcinoid of the gallbladder in two dogs

et al. 2020

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A carcinoid is a rare neoplasm derived from neuroendocrine cells that may arise in the hepatobiliary system. This report described two cases of carcinoid of the gallbladder in dogs, with emphasis on the clinical, pathological and immunohistochemical aspects. Case 1 was a 10-year-old female Shih Tzu, with a history of prostration and occasional episodes of diarrhea and vomiting. Case 2 was a 10-year-old male Cocker Spaniel, with a history of diarrhea and abdominal pain. Abdominal ultrasonography suggested a neoplasm of the gallbladder in both cases. The dogs underwent cholecystectomy, and 10% formalin-fixed samples were sent for pathological examination. Histologically, a neoplastic proliferation of neuroendocrine cells was observed in the gallbladder submucosa of both cases. Immunohistochemical labeling for neuroendocrine antibodies, such as synaptophysin, neuron-specific enolase and chromogranin A, confirmed the diagnoses. Carcinoid of the gallbladder is a rare neoplasm in dogs, without specific clinical signs, but should be included in the differential diagnosis of lesions that affect this organ.

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confidence: 48%

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confidence: 99%

Carcinoid of the gallbladder in two dogs

et al. 2020

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“…They can be identified via ultrasound or exploratory surgery, and are removed via cholecystectomy. 1,2,8,14…”

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confidence: 99%

“…10 In humans, paraneoplastic gastrin synthesis and secretion by gallbladder NECs (GB-NECs) has been noted, indicating that gastrin may be useful for immunohistochemical (IHC) identification of these tumors in dogs as well. 2,4…”

Section: Introductionmentioning

confidence: 99%

“…GB-NECs have been described rarely in domestic animals, including dogs, cats, and cattle, and thus little is known about their biological behavior. 2,3,5,8-11,14 Existing literature primarily includes single descriptive case studies highlighting presentation, diagnosis, and treatment of the GB-NEC, with 1 IHC study of 10 dogs with GB-NEC. 1,2,5,8,11,14 In humans, NECs account for <1% of all malignant tumors, and primary gallbladder neuroendocrine tumors represent only 0.2% of all neuroendocrine tumors.…”

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confidence: 99%

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Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma

et al. 2020

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In this retrospective descriptive study, we characterized the clinical, histologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma (GB-NEC). Immunohistochemical stains for neuroendocrine (neuron-specific enolase [NSE], chromogranin A, synaptophysin) and gastrin markers were evaluated, and clinicopathologic and follow-up data were obtained for all cases. The average age at diagnosis was 8.9 y, and breeds included 6 Boston Terriers, 2 Bichon Frise, 1 Poodle, 1 English Bulldog, 1 French Bulldog, and 2 mixed-breed dogs. Boston Terriers were overrepresented in this cohort, and therefore a breed predilection is possible. Most dogs were presented with emesis and elevated liver enzyme activities: 13 of 13 had elevated alanine aminotransferase and alkaline phosphatase activities; 8 of 13 had elevated aspartate aminotransferase activity; 7 of 13 had elevated gamma-glutamyl transferase activity. Abdominal ultrasound and/or exploratory surgery revealed a gallbladder mass. All neoplasms had similar histologic features and positive immunoreactivity for NSE, chromogranin A, synaptophysin, and gastrin. Vascular invasion was noted in 8 of 13 neoplasms, and metastasis was present in 6 of 13 cases (4 hepatic and 2 pulmonary metastases). The median survival time was 3.7 y in patients who died; 5 of 8 deaths were directly attributed to the GB-NEC, 3 of which had metastatic spread. GB-NECs have the potential to metastasize; however, surgical excision may be curative in a subset of dogs.

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Hepatobiliary Neoplasia and Cancer Staging

Wiedmeyer¹,

Bryan²

2020

Veterinary Cytology

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Primary neuroendocrine carcinoma of the gallbladder in a dog

Cited by 16 publications

References 2 publications

Carcinoid of the gallbladder in two dogs

Carcinoid of the gallbladder in two dogs

Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma

Hepatobiliary Neoplasia and Cancer Staging

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